Abstract Background & Aims The idea of acute‐on‐chronic liver failure ( ACLF ) has emerged to identify those subjects with organ and high mortality rates. However, the absence a precise definition limited clinical application research related concept. We sought validate CLIF ‐ SOFA Score recently proposed by EASL Consortium in cohort patients admitted for acute decompensation AD cirrhosis. Methods In this prospective study, were followed during their hospital stay thirty 90‐day was...

Introduction. Bacterial infection is a frequent complication in patients with decompensated liver cirrhosis and related to high mortality rates during follow-up of these individuals. We sought evaluate the diagnostic value C-reactive protein (CRP) procalcitonin (PCT) diagnosing investigate relationship between biomarkers after hospital admission. Material methods. Prospective study that included cirrhotic admitted due complications disease. The accuracy CRP PCT for diagnosis was evaluated by...

Introduction. Although it is standard procedure in the evaluation of liver diseases, biopsy an invasive method subject to sampling error and intra or inter-observer variability. Thus, surrogate markers fibrosis have been proposed, with variable availability accuracy. Aim. Validate compare performance APRI FIB-4 as predictors HCV patients. Material methods. Cross-sectional study including patients HCV-RNA (+) who underwent biopsy. Significant was defined METAVIR stage ≥ 2. The diagnostic...

Introduction. Adiponectin and resistin levels are increased in patients with cirrhosis, but it prognostic significance is unknown. We sought to investigate the factors associated adiponectin its clinical cirrhosis. Materials methods. This was a prospective cohort study that included 122 subjects cirrhosis who attended an outpatient clinic were initially evaluated 2012. Serum measured samples collected 2012 (adiponectin resistin) 2014 (adiponectin). Thirty healthy served as control group....

Introduction: The first months after the hospitalization of cirrhotic patients are considered at high risk for new complications. Knowing factors associated with early readmission in these individuals may contribute to development preventive strategies that avoid risks and costs related a hospitalization. Objective: To investigate hospitalized due acute decompensation cirrhosis. Methods: Data from each patient was during study period were followed up 90th day by telephone contact. A...

Autoantibodies are often produced during infection with chronic hepatitis C virus (HCV), but it remains controversial whether they influence the biochemical profile and histological features of this disease. Therefore, current study sought to describe these autoantibodies evaluate their impact on clinical presentation C.This cross-sectional analytical assessed patients HCV (RNA+) from October 2011 July 2012.This included 66 patients, a mean age 53.2±10.5 years. Of 60.6% were male, 54.3%...

To investigate the prognostic significance of thyroid hormone profile in patients hospitalized for decompensated cirrhosis.

Infection by multidrug resistant bacteria is arousing as a relevant issue among hospitalized subjects and of particular interest in patients with cirrhosis given the frequent use broad spectrum antibiotics their altered immune response. We report first case spontaneous bacterial peritonitis (SBP) caused Enterococcus casseliflavus sixth SBP gallinarum.

Background. Although several prognostic models have been proposed for cirrhotic patients listed transplantation, the performance of these scores as predictors mortality in admitted acute decompensation cirrhosis has not satisfactorily investigated. Aims. To study MELD, MELD-Na, MESO, iMELD, Refit-MELD and Refit MELD-Na decompensation, to compare their between admission 48 hours hospitalization predict in-hospital mortality. Material methods. This cohort included hospital due complications...

IGF-I and IGFBP-3 are part of IGF system and, due to their predominantly hepatic synthesis, they seem correlate with dysfunction intensity.To investigate the significance in patients decompensated liver disease.Cross-sectional study that included cirrhotic admitted hospital complications disease, whom serum levels were measured by chemiluminescence.Seventy-four subjects a mean age 53.1 ± 11.6 years study, 73% males. positively correlated albumin, negatively Child-Pugh, MELD, creatinine, INR...

Introduction Chronic hepatitis B virus (HBV) infection and liver steatosis (LS) are the most common causes of chronic disease, their coexistence is frequently observed in clinical practice. Although metabolic syndrome main cause LS, it has not been associated with HBV infection. The aims this study were to describe lipid profile prevalence LS among carriers identify characteristics group. Methods This retrospective cross-sectional included surface antigen (HBsAg)-positive patients evaluated...

Eosinophilic gastroenteritis is a rare disease that characterized by eosinophil infiltration in one or multiple segments of the gastrointestinal tract. The etiology this condition remains unknown. has heterogeneous clinical manifestations depend upon location and depth tract, eosinophilia may not be present. This article reports two cases eosinophilic gastroenteritis. first 49-year-old woman with abdominal pain, ascites, eosinophilia, history asthma. second case 69-year-old male loss...

Abstract Background & Aims An algorithm including Sepsis‐3 criteria and quick Sequential Organ Failure Assessment (qSOFA) was recently proposed to predict severity of infection in cirrhosis. However, its applicability among patients without a baseline SOFA available for definition is unknown. We sought investigate the prognostic value qSOFA with cirrhosis hospitalised bacterial infections, pre‐hospitalisation SOFA. Methods In this cohort study, 164 were followed up 30 days. Data...

Celiac disease is an autoimmune disorder with average prevalence of 1% in Europe and the United States. Because strong European ancestry southern Brazil, this study aimed to evaluate seroprevalence celiac among thyroiditis patients.Cross-sectional a public university hospital.This cross-sectional included patients who were tested for anti-endomysial anti-transglutaminase antibodies between August 2010 July 2011.Fifty-three included; 92.5% women, mean age 49.0 ± 13.5 years. Five (9.3%)...

Celiac disease is an autoimmune disorder that involves gluten intolerance and can be triggered by environmental factors including hepatitis B virus (HBV) infection. This study aimed to describe the prevalence of celiac in individuals with HBV infection clinical laboratory characteristics associated HBV.This cross-sectional included 50 patients tested for IgA anti-endomysial antibodies (EMAs) tissue anti-transglutaminase (TTG) between August 2011 September 2012.Fifty were a mean age 46.0 ±...

Besides the great importance of issue in terms public health, there is a lack studies evaluating performance several currently used point care tests (POCTs) for detection anti-HCV.To investigate two POCTs anti-HCV and to assess impact reading time on diagnostic performance.A total 307 subjects were divided into three groups (1- HCV infected; 2- other chronic liver diseases; 3- controls). The Rapid Test Bioeasy® Imuno-Rapido HCV® read at 3, 5, 10, 15, 20 30 minutes. sensitivity specificity...

Spontaneous bacterial peritonitis (SBP) is a severe complication that occurs in 8-27% of hospitalized patients with liver cirrhosis and ascites, high mortality rates. This study aimed to identify the clinical characteristics associated SBP.

AIM:To investigate the prognostic significance of insulin-like growth factor-binding protein 3 (IGFBP-3) in patients with cirrhosis. METHODS:Prospective study that included two cohorts: outpatients stable cirrhosis (n = 138) and hospitalized for acute decompensation 189).Development complications, mortality or liver transplantation was assessed by periodical phone calls during outpatient visits.The cohort also underwent clinical laboratory evaluation yearly (2013 2014) predefined visits.In...

Background. Although recently challenged, systemic inflammatory response syndrome (SIRS) criteria are still commonly used in daily practice to define sepsis. However, several factors liver cirrhosis may negatively impact its prognostic ability. Goals. To investigate the associated with presence of SIRS, characteristics SIRS related infection, and value among patients hospitalized for acute decompensation cirrhosis. Study. In this cohort study from two tertiary hospitals, 543 were followed...

Introduction and aim. New criteria for acute kidney injury (AKI) in cirrhosis have been proposed, but its prognostic significance is unclear. This study aims to evaluate the of AKI cirrhotic patients hospitalized decompensation. Material methods. a prospective cohort study. was defined as an increase creatinine (Cr) levels ≥ 0.3 mg/dL 48 h or 50% basal value last 7d. divided into stages 1 (elevation: < 2x basal), 2 (2 3x), 3 (> 3x). Results. In this study, 227 aged 53.9 ± 11.5 years were...

Introduction. Lower 25-hydroxyvitamin D [25(OH)D] levels have been observed in cirrhotic patients and related to disease severity. However, most previous studies included with very advanced disease, lacking an adequate control for other variables that could interfere vitamin levels. We sought investigate the prevalence of hypovitaminosis factors its occurrence. Material methods. This cross-sectional study 133 30 healthy controls. Bivariate multivariate analyses were performed determine...

The "spot" urine sodium/potassium (Na/Ku) ratio is a convenient tool to identify sodium excretion < 78 mequiv./d. It has been established that this as useful and accurate 24-h (Nau24h), but no Latin American study evaluated issue. aim of evaluate the accuracy Na/Ku compare it Nau24h. This cross-sectional included 20 patients with decompensated liver cirrhosis ascites. Mean age was 56.1 ± 11.8 years old, 70% were men 60% presented Nau24h Poor group higher MELD score (P = 0.002), creatinine...

IGF-I serum levels are suppressed in cirrhosis, but its prognostic significance is unknown.To investigate the value of patients admitted for acute decompensation cirrhosis.Cohort study that included 103 patients. was measured by enzyme-linked immunosorbent assay (ELISA).Ninety-day mortality 26.2% and it independently associated with MELD, age IGF-I. The Kaplan-Meier survival probability at 90 days 94.3% ≥13 ng/mL 63.2% <13 (p = .001).IGF-I cirrhosis.