A5081415565- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Drug-Induced Adverse Reactions
- Bacterial Identification and Susceptibility Testing
- Infections and bacterial resistance
- Nosocomial Infections in ICU
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Urinary Tract Infections Management
- Nursing education and management
- Neutropenia and Cancer Infections
- Acute Kidney Injury Research
- Respiratory viral infections research
- Healthcare professionals’ stress and burnout
- Lymphadenopathy Diagnosis and Analysis
- Antifungal resistance and susceptibility
- SARS-CoV-2 and COVID-19 Research
- Pharmaceutical industry and healthcare
- Poisoning and overdose treatments
- Bacterial biofilms and quorum sensing
- Platelet Disorders and Treatments
- Innovations in Medical Education
The Ohio State University Wexner Medical Center
2017-2025
Abstract Objective To compare the rate of clinical cure and adverse effects in patients receiving definitive treatment with trimethoprim-sulfamethoxazole versus minocycline monotherapy for Stenotrophomonas maltophilia pneumonia. Methods A single-centre, retrospective cohort study S. pneumonia admitted 1 March 2018—30 September 2023 was conducted comparing monotherapy. The primary outcome cure, defined as meeting two three prespecified criteria a period 48 hours while on therapy:...
Abstract Accurate kidney function assessment is essential for medication dosing, although traditional methods such as urine output and serum creatinine are limited, especially in patients with acute injury. Cystatin C was made available an alternative marker at our institution, prompting the formation of a multidisciplinary task force to guide its use resolve discrepancies clinical practice using Plan‐Do‐Study‐Act framework. validated approach developing evaluating interventions ensure that...
Stenotrophomonas maltophilia is intrinsically resistant to several antibiotics, making it potentially challenging treat. Studies have demonstrated treatment failures and resistance development with monotherapy (MT); however, clinical data are limited combination therapy (CT).To compare outcomes CT versus MT for S. pneumonia.This was a retrospective cohort study of patients admitted between November 2011 October 2017 pneumonia who received at least 48 h effective therapy. The primary outcome...
We sought to define trends in and predictors of carbapenem consumption across community, teaching, university-affiliated hospitals the United States Canada. conducted a retrospective multicenter survey broad-spectrum noncarbapenem beta-lactam between January 2011 December 2013.
Lower mortality has been observed with combination therapy compared to monotherapy for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia; however, there is a lack of evidence continued over de-escalation following bacteremia clearance.This was single-center, retrospective study evaluating patients MRSA hospitalized from November 1, 2011, through July 31, 2019. Patients who received three ten days followed by were directly retained on therapy. The primary composite outcome...
Objectives To identify the impact of penicillin versus alternative β‐lactams on clinical outcomes in patients with penicillin‐susceptible Staphylococcus aureus ( PSSA ) bacteremia. Design Retrospective cohort study. Setting Academic medical center. Patients Adult bacteremia treated a β‐lactam as definitive therapy. Measurements The primary outcome was composite end point 30‐day failure (change therapy due to persistent or worsening signs and symptoms, recurrence persistence, and/or...
Daptomycin is associated with a number of adverse effects including eosinophilic pneumonia, hypersensitivity reaction, myopathy, rhabdomyolysis, headache and transaminitis. The high-dose daptomycin have not been fully evaluated in patients end-stage renal disease (ESRD).To determine the incidence characteristics significant receiving severe dysfunction.A single-centre, retrospective study was conducted to assess safety outcomes an estimated creatinine clearance less than 30 mL/min. Adult...
Staphylococcus aureus (S. aureus) is the leading cause of bacteraemia and infective endocarditis worldwide. The preferred management patients with methicillin-susceptible S. (MSSA) includes definitive therapy intravenous anti-staphylococcal beta-lactam (ASBL) antibiotics. Daptomycin (DAP) has been targeted as a viable substitute for allergic or intolerant patients. This single-center retrospective cohort study assessed clinical outcomes DAP compared ASBL antibiotics [nafcillin (NAF)...
Abstract Ensuring appropriate dosing of medications is an essential practice clinical pharmacists. Dose adjustments in the setting decreased renal function are common but may also be warranted for patients with supraphysiologic or augmented clearance (ARC). Conventional estimates creatinine using only serum not accurate ARC, thus a measured and urine measurements preferred. We describe development 8‐h collection ARC program at large academic medical center initiated by critical care...
The objective of this study was to compare the rate pneumonia resolution in obese (body mass index [BMI], ≥30 kg/m
The prevalence of penicillin-susceptible S. aureus (PSSA) has increased in recent years. However, non-penicillin β-lactams (BLs) are often utilized for the treatment PSSA bacteremia. To date, there limited data on management bacteremia and its associated outcomes. aim this study is to identify impact penicillin (PCN) vs. alternative BLs clinical outcomes patients with Patients admitted Ohio State University Wexner Medical Center between July 2011 June 2016 who were treated an intravenous BL...
Pharmacy residents are especially vulnerable to burnout given the professional and personal stressors associated with postgraduate training. Residency programs need prioritize reduction strategies support resident health well-being. This commentary describes a resident-preceptor collaborative approach encourage wellness reduce within large residency program at an academic medical center. Strategies that have been utilized include (1) fostering collaboration among preceptors; (2) assessing...
Results.In 2013, >1 antibiotic dose/day was prescribed to 16.2% of VA dental patients (total = 476,451 patients).By class, aminopenicillins were most frequently (69.4%), followed by lincomycins (21.9%).The overall mean AD 11.4 (range 1-309) days and DOT 11.5 (1-309).Of the Veterans who received an from a dentist, only 2.3% broad-spectrum agent.However, (15.0) significantly longer than narrow spectrum (11.2;P < 0.0001). Conclusion.While prevalence prescribing low, patient-level duration...
1N/A, Columbus, OH, 2The Ohio State University, 3The University Wexner Medical Center, 4The Stae OH
Stenotrophomonas maltophilia is an emerging nosocomial pathogen with intrinsic resistance to several antibiotics, making it potentially challenging treat. Studies have demonstrated treatment failures and development monotherapy (MT); however, limited clinical data improved outcomes combination therapy (CT). The aim of this study was compare CT vs. MT for S. pneumonia. This a retrospective cohort patients admitted OSUWMC between November 2011 October 2017 pneumonia who received at least 48...
A rapid and accurate meningitis/encephalitis diagnostic test can have a significant clinical impact improve utilization of antimicrobial agents. The FilmArray Meningitis/Encephalitis Panel, multiplex PCR panel (MEP) (bioMérieux, Marcy l’Etoile, France) requires only 200 μL cerebral spinal fluid (CSF) takes less than 1 hour to simultaneously detect 14 pathogens. objective the study was evaluate outcome MEP at our medical center. Retrospective review 433 patients with an performed from April...
Abstract Background The preferred management of patients with MSSA bacteremia includes definitive therapy intravenous anti-staphylococcal β-lactam antibiotics. In allergic or intolerant patients, daptomycin has been targeted as a viable alternative. objective this study was to assess clinical outcomes compared nafcillin cefazolin for the treatment bacteremia. Methods This retrospective cohort hospitalized from November 1, 2011 October 31, 2018 at Ohio State University Wexner Medical Center...
Abstract Background The Infectious Diseases Society of America’s guideline for implementing antibiotic (abx) stewardship recommends routine review abx use. Several studies demonstrate time out (ATO) programs result in de-escalation, but there is limited evidence improved outcomes. aim this study was to evaluate the clinical impact ATO. Methods This retrospective included hospitalized patients at Ohio State University Wexner Medical Center receiving and a documented ATO from 7/1/2017...
Background: Various strategies aimed at limiting inappropriate antimicrobial use including antibiotic time out (ATO) have been proposed to combat the development of resistance, yet there are limited studies that assessed impact ATO on clinical outcomes. Methods: This single-center retrospective study reviewed effect a passive strategy by comparing 100 adult patients with an matched infection type antibiotic-treated lacking note. Results: No difference in outcomes was observed, however, did...
Abstract Background Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with increased morbidity and mortality. Previous studies have demonstrated lower mortality combination therapy (CT) compared to monotherapy (MT) for MRSA bacteremia; however, there a lack of evidence favor continued CT over de-escalation MT completion treatment after clearance bacteremia. Methods This was single-center, retrospective study at The Ohio State University Wexner Medical...