A5054641445- Natural Antidiabetic Agents Studies
- Diet, Metabolism, and Disease
- Retinoids in leukemia and cellular processes
- Cassava research and cyanide
- Muscle Physiology and Disorders
- Liver Disease Diagnosis and Treatment
- Cell death mechanisms and regulation
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Advanced Glycation End Products research
Universidade Estadual Paulista (Unesp)
2014-2021
Species of Myrcia are used by indigenous people and in traditional communities Brazil for the treatment Diabetes mellitus. We investigated hypoglycemic effect extract leaves bella diabetic mice. The chemical fingerprinting 70% EtOH characterized as main constituents flavonoid aglycones, flavonoid-O-glycosides, acylated flavonoid-O-glycosides derivatives quercetin myricetin. Mice were treated with saline or M. (300 600 mg/Kg b.w.) 14 days. Body weight water food intake measured every day....
Bauhinia holophylla leaves, also known as "pata-de-vaca", are traditionally used in Brazil to treat diabetes. Although the hypoglycemic activity of this medicinal plant has already been described, active compounds responsible for have not yet identified. To rapidly obtain two fractions large amounts compatible with further vivo assay, hydroalcoholic extract B. leaves was fractionated by Vacuum Liquid Chromatography and then purified medium pressure liquid chromatography combined an Glucose...
Fibrates are used as lipid-lowering drugs and well tolerated cotreatments when glucose metabolism disturbances also present. Synthetic glucocorticoids (GCs) diabetogenic that cause dyslipidemia, dysglycemia, intolerance, insulin resistance in excess. Thus, we aimed to describe the potential of bezafibrate preventing or attenuating adverse effects GCs on lipid homeostasis. Male Wistar rats were treated with high-dose (300 mg/kg, body mass (b.m.)) daily for 28 consecutive days. In last five...
Abstract Background Cancer is a multifactorial disease caused by uncontrolled proliferation of cells. About 50–80% cancer patients develop cachexia, complex metabolic syndrome associated with an increase mortality and morbidity. However, there are no effective therapies in medical clinic for cachexia. Vochysia tucanorum Mart. common three the Brazilian “Cerrado”. The butanolic fraction V. (Fr-BuVt), very rich triterpenes various biological activities, might be interesting being tested...