Gerard Nowak

ORCID: 0000-0002-3544-546X
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About
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Research Areas
  • Sesquiterpenes and Asteraceae Studies
  • Natural product bioactivities and synthesis
  • Plant Toxicity and Pharmacological Properties
  • Phytochemistry and Biological Activities
  • Toxin Mechanisms and Immunotoxins
  • Biological Activity of Diterpenoids and Biflavonoids
  • Medicinal plant effects and applications
  • Traditional and Medicinal Uses of Annonaceae
  • Herbal Medicine Research Studies
  • Medicinal Plant Extracts Effects
  • Marine Sponges and Natural Products
  • Essential Oils and Antimicrobial Activity
  • Cynara cardunculus studies
  • Synthetic Organic Chemistry Methods
  • Insect Pheromone Research and Control
  • Skin Protection and Aging
  • Plant Ecology and Taxonomy Studies
  • Pharmacological Effects of Natural Compounds
  • Medicinal Plants and Bioactive Compounds
  • X-ray Diffraction in Crystallography
  • Insect Pest Control Strategies
  • Crystallization and Solubility Studies
  • Bee Products Chemical Analysis
  • Phytochemical compounds biological activities
  • Natural Compounds in Disease Treatment

Medicina
1984-2025

Pomeranian Medical University
2023-2024

Poznan University of Medical Sciences
2010-2023

National Veterinary Research Institute
2004

National Institute on Drug Abuse
1994

Adam Mickiewicz University in Poznań
1993

New York Academy of Medicine
1993

Institute of Organic Chemistry
1992

Polish Academy of Sciences
1992

Summary Background Arbutin is one of the most effective lightening substances. Serratula quinquefolia a new source its β ‐anomer. The HPLC method showed that solid content this compound in dried plant raw material accounts for 6.86%. leaves do not contain hydroquinone. Aims To assess efficacy aqueous extract from' leaf five‐leaf serratula as skin‐lightening agent. Patients/Methods We did randomized, placebo‐controlled, double‐blind trial. study involved 102 women aged 26–55, with two kinds...

10.1111/jocd.12147 article EN Journal of Cosmetic Dermatology 2015-06-28

The milky juice of the greater celandine herb has been used in folk medicine and homeopathy for treatment viral warts years. However, classical fails to use properties herbs diseases induced by papilloma viruses. Nevertheless, dermatological outpatient clinics are regularly visited patients reporting efficacy sap isolated from their own warts. Authors this report decided analyze respective world literature order critically evaluate potential dermal using celandine. Moreover, case a 4-year...

10.3390/ijerph17051540 article EN International Journal of Environmental Research and Public Health 2020-02-27

This paper presents raw plant materials and their characteristic compounds which may affect the immune system. Plant-derived agents in specific doses body’s non-specific, antigen-independent defense They have immunostimulatory effects on entire regulatory can enhance response through various factors such as macrophages, leukocytes, granulocytes, well mediators released by cellular was inspired threats caused COVID-19 pandemic. The proper functioning of system is important limiting viral...

10.3390/app13116477 article EN cc-by Applied Sciences 2023-05-25

The occurrence of both known and new sesquiterpene lactones was determined in six species classified different subgenera <em>Centaurea L. </em>Chlorojanerin, cynaropicrin janerin were isolated from <em>C. phaeopappoides </em>Bordz. thracica </em>(Janka) Hayek. marschalliana </em>Spreng. found to contain acroptilin, chlorojanerin, cebellin D while adjarica </em>Alb. had repin, centaurepensin, janerin, repidiolide, D, E, F L A new, hitherto...

10.5586/asbp.1989.008 article EN cc-by Acta Societatis Botanicorum Poloniae 2013-04-12

Cnicin was isolated from 18 species or subspecies of the subgenus <em>Acrolophus</em> (Cass.) Dobrocz.: <em>Centaurea aplolepa</em> Moretti subsp. <em>aplolepa</em>, <em>C. <em>lunensis</em> (Fiori) Dostal, arenaria</em> Bieb. ex Wild. <em>arenaria, C. Wild, <em>odessana</em> (Prodan) Bieb <em>majorowii</em> (Dumbadze) calvescens</em> Pančić, cineraria</em> L. <em>cineraria, var,...

10.5586/asbp.1984.018 article EN cc-by Acta Societatis Botanicorum Poloniae 2014-01-01

Guaianolides were found in three species of the genus <em>Leuzea</em> DC. Chlorojanerin, cynaropicrin and janerin isolated from <em>L. rhapontica</em> subg. <em>helenifolia</em> (Gren, Gordon) Holub rhaponticoides</em> Graells. From carthamoides</em> (Willd.) DC., chlorojanerin, cynaropicrin, janerin, cebellin E repdiolide obtained.

10.5586/asbp.1988.015 article EN cc-by Acta Societatis Botanicorum Poloniae 2014-01-01

Phytoecdysteroids are natural compounds with therapeutic benefits in both humans and animals. The effectiveness of products health potential is based on the activities potencies their active ingredients. In this study, dominant ecdysteroids—ajugasterone C, 20-hydroxyecdysone polypodine B—from Serratula coronata (S. coronata) herb were separated by column chromatography, identified spectroscopic data quantified high-performance liquid chromatography a diode array detector (HPLC-DAD). obtained...

10.3390/ijerph17186453 article EN International Journal of Environmental Research and Public Health 2020-09-04

The presence of cynaropicrin was determined in 13 species the subtribe <em>Centaureinae</em> Dumort.: <em>Centaurea declinata</em> M. B.- <em>C. leucophylla</em> B.. dealbata</em> Willd.. zangezuri</em> (Sosn.) Sosn., carthalinica</em> thracica</em> (Janka) Hayek, exarata</em> Boiss. ex Cosson, phaeopappoides</em> Bordz., <em>Chartolepis intermedia</em> Bioss., <em>Ch. glastifolia</em> (L.) Cass.,...

10.5586/asbp.1986.003 article EN cc-by Acta Societatis Botanicorum Poloniae 2014-01-01

Hepatocellular damage by the harmful effects of xenobiotics, which increase production free radicals, is a widespread phenomenon. The extract from leaves Cynara scolymus L. available as an artichoke preparation (natural source) antioxidants may serve potential hepatoprotective factor. This study aimed to evaluate impact protective and regenerative properties on liver in three doses: 0.5; 1.0; 1.5 g/kg bw/day. evaluation was conducted measuring levels oxidative stress parameters, including...

10.3390/antiox12101846 article EN cc-by Antioxidants 2023-10-11

Genus <em>Serratula</em> is known for the presence of steroid compounds which belong to group ecdysones. Former phytochemical works from late sixties and early seventies indicate, in some species, occurrence a phenolic glycoside-arbutin. This has been confirmed present work through finding an α,β-arbutin anomer <em>Serratula quinquefolia</em> M.B. New botanical data concerning classification genus suggest that species question should be regarded as belonging...

10.5586/asbp.2009.018 article EN cc-by Acta Societatis Botanicorum Poloniae 2011-01-01

Nine new guaianolides. I of which are chlorinated, were isolated from the dried, above-ground parts <em>Centaurea bella</em> Trautv. They are: cebellin A. B, C, D, E. F, G, H and 1. l he known guaianolides centaurepensin repdiolide also found. The occurrence repin. acroptillin janerin was confirmed. Cebellin F. G. chromatographically shown to occur in adjarica</em> Alb.

10.5586/asbp.1986.022 article EN cc-by Acta Societatis Botanicorum Poloniae 2014-01-01

Three germacranolides, as well five flavonoids, natural steroid and simple phenolic compounds, were isolated from the inflorescence of Stizolophus balsamita growing in Iran. The paper presents active compounds found for first time this species. steroids have been genus Stizolophus. MTT assay was employed to study vitro cytotoxic effects taxifolin against human fibroblasts. We also evaluate possible biological properties/cosmetic extract on skin. Sixty healthy Caucasian adult females with no...

10.3390/ijms22094428 article EN International Journal of Molecular Sciences 2021-04-23

Due to increasing resistance of pathogenic fungi antifungal treatments, new types drugs are needed. For this purpose, active substances with properties occurring in natural compounds should be considered. The herb Psephellus bellus shows strong activity and is characterized by unique guaianolides, which have an ester on C-2. Thus, a specialized method isolation testing was applied assess the pharmacological effects these guaianolides. After phytochemical analysis (chromatography spectral...

10.3390/plants10061180 article EN cc-by Plants 2021-06-09

The occurrence of syringin in eight out ten investigated plant species the subtribe Centaureinae (Asteraceae) was reported. compound isolated from aerial parts plants by silica gel column chromatography methanol extracts. Contents varied 0.001 to 0.1% dried material. <em>Centaurea bella </em>Trautv. appeared be best source this (0.1% dry wt.). Syringin has been reported for first time these species.

10.5586/asbp.2003.013 article EN cc-by Acta Societatis Botanicorum Poloniae 2011-01-01
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