A5002899429- Cellular Mechanics and Interactions
- Neurobiology and Insect Physiology Research
- Developmental Biology and Gene Regulation
- Hippo pathway signaling and YAP/TAZ
- Cell death mechanisms and regulation
- Microtubule and mitosis dynamics
- 3D Printing in Biomedical Research
- Phagocytosis and Immune Regulation
- Planarian Biology and Electrostimulation
- Neonatal Respiratory Health Research
- Invertebrate Immune Response Mechanisms
- Photoreceptor and optogenetics research
- Nuclear Structure and Function
- Neuroscience of respiration and sleep
- Ion channel regulation and function
- Ion Channels and Receptors
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Tendon Structure and Treatment
- Cancer Cells and Metastasis
- Axon Guidance and Neuronal Signaling
- Force Microscopy Techniques and Applications
- Spaceflight effects on biology
- Insect Resistance and Genetics
- Advanced Fluorescence Microscopy Techniques
- Heat shock proteins research
Université Toulouse III - Paul Sabatier
2015-2025
Centre National de la Recherche Scientifique
2011-2025
Université de Toulouse
2015-2025
Laboratoire de Microbiologie et Génétique Moléculaires
2024-2025
Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération
2015-2020
Centre de Biologie du Développement
2017-2019
Institut de Biologie du Développement Marseille
2005-2011
University of Cambridge
2009-2011
Centre d’Immunologie de Marseille-Luminy
2011
Far from being passive, apoptotic cells influence their environment. For example, they promote tissue folding, myoblast fusion and modulate tumor growth. Understanding the role of necessitates efficient tracking within living tissues, a task that is currently challenging. In order to easily spot in developing Drosophila we generated series fly lines expressing different fluorescent sensors caspase activity. We show three these reporters (GFP-, Cerulean- Venus-derived molecules) are detected...
Mechanical forces are critical regulators of cell shape changes and developmental morphogenetic processes. Forces generated along the epithelium apico-basal axis have recently emerged as essential for tissue remodeling in three dimensions. Yet cellular machinery underlying those orthogonal remains poorly described. We found that during Drosophila leg folding cells eventually committed to die produce through formation a dynamic actomyosin contractile tether connecting apical surface basally...
In the Drosophila larval cardiac tube, aorta and heart differentiation are controlled by Hox genes Ultrabithorax (Ubx) abdominal A (abdA), respectively. There is evidence that tube undergoes extensive morphological functional changes during metamorphosis to form adult organ, but both origin of myocytes underlying genetic control have not been established. Using in vivo time-lapse analysis, we show fruit fly formed reprogramming differentiated already cardiomyocytes, without cell...
Tissue mechanics play a crucial role in organ development. They rely on the properties of cells and extracellular matrix (ECM), but relative physical contribution ECM to morphogenesis is poorly understood. Here, we have analyzed behavior peripodial epithelium (PE) Drosophila leg disc light dynamics its cellular components. The PE undergoes successive changes during development, including elongation, opening removal free leg. During found that cell layer are progressively uncoupled....
Epithelial sheets undergo highly reproducible remodeling to shape organs. This stereotyped morphogenesis depends on a well-defined sequence of events leading the regionalized expression developmental patterning genes that finally triggers downstream mechanical forces drive tissue at pre-defined position. However, how mechanics controls morphogenetic robustness when challenged by intrinsic perturbations in close proximity has never been addressed. Using Drosophila developing leg, we show bias...
Protein function is encoded within protein sequence and domains. However, how domains cooperate a to modulate overall activity this impacts functional diversification at the molecular organism levels remains largely unaddressed. Focusing on three of central class Drosophila Hox transcription factor AbdominalA (AbdA), we used combinatorial domain mutations most known AbdA developmental functions as biological readouts investigate collectively shape activity. The results uncover redundancy,...
SUMMARY Tumours evolve through the acquisition of increasingly aggressive traits associated with dysplasia. This progression is accompanied by alteration tumour mechanical properties, especially extracellular matrix remodelling. However, contribution intrinsic cells mechanics to aggressiveness remains unknown in vivo . Here we show that adherens junction tension pre-tumoral tissues dictates subsequent evolution. Increased cell contractility, observed tumours before any sign tissue...
Abstract Tissue mechanics play a crucial role in organ development. It relies on cells and extracellular matrix (ECM) mechanical properties, but also their reciprocal interaction. The relative physical contribution of ECM to morphogenesis is poorly understood. Here, we dissected the envelope Drosophila developing leg, an epithelium submitted number stresses: first stretched, it then torn apart withdrawn free leg. During stretching, found that tension entirely borne by at first, cellular...
Abstract Epithelial sheets undergo highly reproducible remodeling to shape organs. This stereotyped morphogenesis depends on a well-defined sequence of events leading the regionalized expression developmental patterning genes that finally triggers downstream mechanical forces drive tissue at pre-defined position. However, how mechanics controls morphogenetic robustness when challenged by intrinsic perturbations in close proximity has never been addressed. Here, we show bias force propagation...
intégré sur le cancer -programme research for personalized medicine (CARPEM), l'association des gastroentérologues oncologues, labex immunooncology.