A5046842986- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- Cytomegalovirus and herpesvirus research
- Respiratory viral infections research
- Parvovirus B19 Infection Studies
- Hematological disorders and diagnostics
- Healthcare Decision-Making and Restraints
- Asthma and respiratory diseases
- Hematopoietic Stem Cell Transplantation
- Mycobacterium research and diagnosis
- Polyomavirus and related diseases
- Sepsis Diagnosis and Treatment
- Respiratory and Cough-Related Research
- Pneumonia and Respiratory Infections
- Dermatological and COVID-19 studies
- Schizophrenia research and treatment
- Virus-based gene therapy research
- Complement system in diseases
- HIV Research and Treatment
- T-cell and B-cell Immunology
- Nosocomial Infections in ICU
- Mental Health and Psychiatry
- Blood disorders and treatments
- Influenza Virus Research Studies
- Viral Infections and Immunology Research
Karolinska University Hospital
2010-2021
Karolinska Institutet
2010-2021
Acute respiratory illness (ARI) accounts for a large proportion of all visits to pediatric health facilities. Quantitative real-time polymerase chain reaction (qPCR) analyses allow sensitive detection viral nucleic acids, but it is not clear what extent specific viruses contribute disease because many have been detected in asymptomatic children. Better understanding how interpret findings important reduce unnecessary use antibiotics.To compare qPCR from children with ARI versus control...
<h3>Background</h3> Community-acquired pneumonia (CAP) is the leading cause of death in children worldwide and a substantial proportion childhood CAP caused by viruses. A better understanding role virus infections this condition needed to improve clinical management preventive measures. The aim study was therefore assess association between specific respiratory viruses CAP. <h3>Methods</h3> case–control conducted during 3 years Stockholm, Sweden. Cases were aged ≤5 with radiological Healthy...
Abstract Leukemic patients are often immunocompromised due to underlying conditions, comorbidities and the effects of chemotherapy thus at risk for developing systemic infections. Bloodstream infection (BSI) is a severe complication in neutropenic associated with increased mortality. BSI routinely diagnosed blood culture, which only detects culturable pathogens. We analyzed 27 samples from 9 acute leukemia suspected different time points their antimicrobial treatment using shotgun...
Background Bloodstream infection (BSI) is a common and potentially life-threatening complication in patients with hematological malignancies therapy-induced neutropenia. Administration of broad spectrum antibiotics has substantially decreased the mortality rate febrile neutropenia, but bacterial documented only one-third or fewer cases. BSI typically diagnosed by blood culture; however, this method can detect culturable pathogens. Methods In present study, total 130 samples from receiving...
Background Until recently, viral infections in patients with hematological malignancies were concerns primarily allogeneic hematopoietic stem cell transplant (HSCT) recipients. During the last years, changed treatment regimens for non-transplanted have had potential to increase incidence of this group. In study, we prospectively investigated prevalence a broad range respiratory viruses nasopharyngeal aspirate (NPA) as well that commonly reactivate after HSCT. Methodology/Principal Findings...
Several studies have compared nasal swabs to the more invasive nasopharyngeal aspirate (NPA) for detection of respiratory viruses. Mostly, comparisons been performed on immunocompetent children with upper tract symptoms. The results range from a relatively poor sensitivity an even higher than NPA. We aimed investigate flocked swab (fNS) immunocompromised adults febrile neutropenia. During 16 months, hematological disorder presenting neutropenia were enrolled in study. Paired samples fNS and...
Aims and method To assess the patients' most influential concerns regarding long-acting injectable antipsychotics (LAIs) mental health professionals' preconceptions about these concerns. For both groups, to level of knowledge LAIs. This cross-sectional study used semi-structured interviews patients with schizophrenia or schizoaffective disorder (n = 164), nurses 43) physicians 20). Results The professionals overestimated many fears LAIs, expressed exceeded actual experiences already on...
Background: The etiology of bacteremia in hematological patients with febrile neutropenia differs geographically and changes over time. Since efficient empirical antibiotic treatment depends on relevant knowledge the bacterial panorama, aim this study was to describe prevalence bacteremia, spectrum, resistance patterns isolates group today. Methods: In a cross-sectional study, routine blood cultures from episodes occurring adult disorders presenting Karolinska University Hospital, Stockholm,...
Background Mannose-binding Lectin protein (MBL) has been suggested to be relevant in the defence against infections immunosuppressed individuals. In a Swedish adult cohort from both underlying disease and iatrogenic treatments for their we investigated role of MBL susceptibility infection. Methods this cross sectional, prospective study, blood samples obtained 96 neutropaenic febrile episodes, representing 82 individuals were analysed single nucleotide polymorphism (SNP) MBL2 gene....
In this study we sought to determine the contribution of microbial translocation febrile episodes with no attributable microbiological cause (Fever Unknown Origin, FUO) in an adult neutropaenic cohort. Endotoxin concentrations were measured chromogenic Limulus Amoebocyte Assay and used as a direct measure bacterial products whilst soluble CD14 (sCD14), ELISA was selected indicator early host response endotoxins. cohort generally elevated but did not differ presentation fever. Further...
The degree of immunosuppression in patients with haematological malignancies treated chemotherapy is routinely measured as number circulating cells (preferable neutrophils) peripheral blood. A parallel decline the T expected, but a possible alteration their functionality has been less well explored. ability to secrete more than one cytokine simultaneously known indicate protective immunity. aim this study was determine whether function altered chemotherapy-induced neutropenia.In...
The recently discovered human parvovirus 4 (PARV4) has been associated with seropositivity for immunodeficiency virus, hepatitis B virus and C virus. High prevalence is seen especially in intravenous drug users. detected blood products persons who have repeatedly transfused shown to be a risk-group. Furthermore, reports from different parts of the world suggesting ranging zero one third healthy population thought cause latent or persistent infection. We investigated presence PARV4 DNA B19...
While a plethora of data describes the essential role systemic CD8+ T cells in control SIV replication little is known about local situ cell immune responses against at intact tissue level, due to technical limitations. In staining, using GagCM9 Qdot 655 multimers, were here combined with laser capture microdissection detect and collect Gag CM9 specific lymph node from infected rhesus macaques. uninfected macaques also collected compared cells. Illumina bead array transcriptional analyses...
Aims and method To assess whether the combination of motivational interviewing psychoeducation affects relapse rate stimulates involvement people with psychosis in their treatment. We conducted an interventional study including patients schizophrenia or schizoaffective disorder treated oral antipsychotics, without previous experience long-acting injectable antipsychotics (LAIs). They were randomised to either a control group. Hospital admissions 18 months before after intervention, switches...
Febrile neutropenia is a common complication in adult patients undergoing chemotherapy for hematological malignancies. A potential causative agent identified approximately one third of the fever episodes. We here investigated whether reactivated infection with human herpes virus 6 (HHV-6), polyoma BK (BKV) and parvovirus B19 (B19V) associated this condition. In cross-sectional study, blood samples were collected at hospitalization who developed neutropenic during non-transplanted Detection...