A series of pyrazolo(dihydro)pyridines was synthesized and evaluated for antileishmanial efficacy against experimental visceral leishmaniasis (VL). Among all compounds, 6d 6j exhibited better activity than miltefosine intracellular amastigotes. Compound (50 mg/kg/day) further studied Leishmania donovani/BALB/c mice via the intraperitoneal route 5 days displayed >91 >93% clearance splenic liver parasitic burden, respectively. Combination treatment with a subcurative dose (5 mg/kg) in BALB/c...

Abstract Background Under-five mortality is a matter of serious concern for child health as well the social development any country. The paper aimed to find accuracy machine learning models in predicting under-five and identify most significant factors associated with mortality. Method data was taken from National Family Health Survey (NFHS-IV) Uttar Pradesh. First, we used multivariate logistic regression due its capability important factors, then techniques such decision tree, random...

Depression among the elderly is well-documented and associated with socio-economic factors, physical mental health conditions. Few studies have focused on older adults' limitations depressive symptoms. However, very little known about marital status' role in such associations, especially India. The present study examines association between self-reported symptoms moderating of status separately for men women.The used data from Longitudinal Ageing Study India (LASI) wave 1, 2017-2018, a...

Immuno-modulators in combination with antileishmanial drug miltefosine is a better therapeutic approach for treatment of Visceral Leishmaniasis (VL) as it not only reduces the dose but also shortens regimen. However, immunological mechanisms behind perceived benefits this therapy have been investigated detail. In present study, we hypothesized that potential use drugs target host addition to parasite might represent an alternative strategy therapy. We immune responses generated Leishmania...

Earlier we have established a carbazole alkaloid (mahanine) isolated from an Indian edible medicinal plant as anticancer agent with minimal effect on normal cells. Here report for the first time that mahanine-treated drug resistant and sensitive virulent Leishmania donovani promastigotes underwent apoptosis through phosphatidylserine externalization, DNA fragmentation cell cycle arrest. An early induction of reactive oxygen species (ROS) suggests mahanine-induced was mediated by oxidative...

Background: To evaluate the efficacy of tab. isosorbide mononitrate 80 mg and misoprostol 400 µg given transvaginal for cervical ripening before surgical evacuation in early embryonic demise upto 12 weeks gestation (missed abortion). Methods: The present randomized controlled trial was conducted Bebe Nanaki mother child care centre, attached to govt. medical college, Amritsar, from August 2011 September 2013 after approval institutional research committee. All 50 women were included...

Background: A hospital based descriptive clinical study to evaluate the incidence of genital tuberculosis among infertile women and correlate presentational symptoms methods diagnosis. Methods: study, after taking consent a total 52 patients were enrolled in study. After evaluation couple with help history examination, semen analysis was performed for male partner. The female partner underwent complete (CBC), erythrocyte sedimentation rate (ESR), chest X-ray, hysterosalpingogram (HSG),...

Abstract Background Quantifying excess deaths and their impact on life expectancy at birth (e 0 ) provide a more comprehensive understanding of the burden coronavirus disease 2019 (COVID-19) mortality. The study aims to comprehend repercussions COVID-19 inequality in age death India. Methods mortality schedule pandemic year 2020 was considered one causes category other infectious diseases addition 21 non-pandemic Global Burden Disease (GBD) data. measures e Gini coefficient zero (G then sex...

Abstract Background Mortality estimates at the subnational level are of urgent need in India for formulation policies and programmes district level. This is first-ever study which used survey data estimation life expectancy birth ( $$ {\text{e}}_{0}$$ ) 640 districts from NFHS-4 (2015-16) 707 NFHS-5 (2019-21) total, male female population India. Methods calculated annual age-specific mortality rates all 36 states population. paper constructed abridged tables estimated $$({e_0})$$ further...

Abstract Background: The outbreak of novel coronavirus disease 2019 (COVID-19) has a wider geographical spread than other previous viruses such as Ebola and H1N1. onset its transmission severity become global concern. policymakers have serious concern for containing the minimising risk death. Aim: This study aims to provide estimates basic reproduction rate (R0) case fatality (CFR) which applies generalised population. Methods: A systematic review was carried out retrieve published in...

Eugenia jambolana (EJ) is an Indian traditional herb widely used for the treatment of diabetes mellitus. This globally marketed as single or multi formulations. Many patients consume EJ extract oral hypoglycemic drugs together. calls a need to assess risks versus benefit this co-administration. In present investigation, pharmacodynamic and pharmacokinetic interactions aqueous seeds at dose 400 mg/kg are studied with 10 hypoglycaemic drug sitagliptin (SITA) by co-administrating them 28 days...

Abstract Background Measuring life expectancy and disparity can assist in comprehending how the COVID-19 pandemic has affected mortality estimates Indian population. The present study aims to at birth national subnational levels before during using NFHS SRS data. Methods measures Life ( $${e}_{0}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mi>e</mml:mi> <mml:mn>0</mml:mn> </mml:msub> </mml:math> ) $${e}_{0}^{\dagger}$$ <mml:msubsup> <mml:mrow> </mml:mrow>...

Background: The study was planned to evaluate awareness of breast feeding among mother, institutional quality indicators early feeding. objective know factors causing delay in initiation, assess knowledge, cultural practices, and hospital regarding initiative.Methods: observational conducted over a period 3months from July 2017-Sept 2017 tertiary care centre India. 118 postnatal mothers were interviewed for time first (dependent variable or outcome), independent variables age, education ,...

Introduction: Anti-angiogenic therapy can produce transient regression in tumor case of Glioblastoma (GBM); however, no prolongation patient survival rate had so far been achieved. Methodology: To address this problem, an effort was made to design and characterize a temozolomide loaded nanosystem for targeting the vasculature brain using polymeric nanoparticles. It included formation Temozolomide (TMZ) Solid-Lipid Nanoparticles (SLNs) their conjugation with polysorbate-80 (P-80) which...

In recent years, high elongation materials are widely used. Therefore, it is important to investigate the tensile properties of for engineering applications. Video extensometer equipment measuring materials’ properties. It uses image processing technology match data points and measures actual deformation. However, when materials, motion blur will appear on collected images, which can affect accuracy matching. this paper, we proposed an matching method based Local Phase Quantization (LPQ)...

Pharmacognosy Magazine,2020,16,68,47-56.DOI:10.4103/pm.pm_272_19Published:March 2020Type:Original ArticleAuthors:Amisha Vora, Alice Varghese, Yusuf Kachwala, Ankit P Laddha, Manju Bhaskar, Jamal Akhtar, and Pawan Yadav Author(s) affiliations:Amisha Vora1, Varghese1, Kachwala1, Laddha2, Bhaskar2, Akhtar3, Yadav3 1 Department of Pharmaceutical Chemistry, Shobhaben Pratapbhai Patel School Pharmacy Technology Management, SVKM's NMIMS, Mumbai, Maharashtra, India 2 Pharmacology, 3 Central Council...

<title>Abstract</title> Background Under-five mortality is one of the major public health issues and directly influences population’s health, social development, economic status countries. Thus, early detection essential to find what efficient prevention can take save it. Therefore, this study will explain how machine-learning techniques help predict important determinants under-five in India. Methods This used data from National Family Health Survey-V We performed tenfold cross-validation...

Though patients with diabetes mellitus are at a high risk of atherothrombotic events, every such event should not be attributed to the disease itself. We present case patient headache and blurring vision for 3 days. Brain imaging revealed right transverse sinus thrombosis acute infarct posterior parieto-occipital region, predominantly in cortical watershed zone. The was on subcutaneous dulaglutide weeks having nausea vomiting. Various causes cerebral venous were ruled out appropriate...