A5103114613- Parasitic Diseases Research and Treatment
- Parasites and Host Interactions
- Insect symbiosis and bacterial influences
- Research on Leishmaniasis Studies
- Phytochemistry and Bioactivity Studies
- Phytochemistry and Bioactive Compounds
- Trypanosoma species research and implications
- Piperaceae Chemical and Biological Studies
- Transgenic Plants and Applications
- vaccines and immunoinformatics approaches
- Antifungal resistance and susceptibility
- Mast cells and histamine
- Pharmacological Effects of Natural Compounds
- RNA and protein synthesis mechanisms
- Biological and pharmacological studies of plants
- Allergic Rhinitis and Sensitization
- Medicinal Plant Extracts Effects
- Glycosylation and Glycoproteins Research
- Rabies epidemiology and control
- Biological Research and Disease Studies
- Multicomponent Synthesis of Heterocycles
- Genomics and Phylogenetic Studies
- Cancer Treatment and Pharmacology
- Virus-based gene therapy research
- Insect Utilization and Effects
Panjab University
2020-2024
Central Drug Research Institute
2011-2021
University of Lucknow
2019-2020
University of Delhi
2016
As part of our drug discovery program for anti-filarial agents from Indian medicinal plants, leaves Eucalyptus tereticornis were chemically investigated, which resulted in the isolation and characterization an agent, ursolic acid (UA) as a major constituent. Antifilarial activity UA against human lymphatic filarial parasite Brugia malayi using vitro vivo assays, silico docking search on glutathione-s-transferase (GST) parasitic enzyme carried out. The was lethal to microfilariae (mf; LC100:...
Lymphatic filariasis caused by Wuchereria bancrofti, Brugia malayi and B. timori, is a debilitating disease with an adverse social economic impact. The infection remains unabated in spite of treatment existing antifilarial drugs diethylcarbamazine (DEC) ivermectin which are chiefly microfilaricides. There therefore, need for macrofilaricides, embryostatic agents better In the present study we explored potential crude extract its molecular fractions plant Taxodium distichum using vitro assay...
Lymphatic filariasis (LF) is a parasitic disease that causes permanent disability (elephantiasis). Currently used antifilarial drugs are failing to control LF and there resurgence in some areas. Looking for new leads, we found Calotropis procera plant parts have been traditional medicine alleviating elephantiasis but the activity not known.In present study, of ethanolic extract (A001) its hexane fraction (F001) C. flowers was investigated using human filarial parasite Brugia malayi.A001 F001...
In our recent studies, Brugia malayi molecules have shown interesting immune-stimulating and immune-suppressive properties. Among these, F6 a pro-inflammatory (54-68 kDa) SDS-PAGE resolved fraction of the parasite when administered with Freund's complete/incomplete adjuvant in animals, elicited both Th1 Th2 type immune responses protects host from filarial parasite.The present study was aimed at developing biodegradable microspheres for antigenic protein to investigate immunoadjuvanticity...