A5061473995- Andrographolide Research and Applications
- Mycobacterium research and diagnosis
- Synthesis and Catalytic Reactions
- Tuberculosis Research and Epidemiology
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Computational Drug Discovery Methods
- Nanoparticle-Based Drug Delivery
- Chemical Synthesis and Reactions
- Ethnobotanical and Medicinal Plants Studies
- Oxidative Organic Chemistry Reactions
- Catalytic C–H Functionalization Methods
- Drug Solubulity and Delivery Systems
- Chemical Synthesis and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Genetic factors in colorectal cancer
- Essential Oils and Antimicrobial Activity
- Natural Antidiabetic Agents Studies
- Carbon and Quantum Dots Applications
- Systemic Lupus Erythematosus Research
- RNA Interference and Gene Delivery
- Pharmacological Effects of Natural Compounds
- Colorectal Cancer Treatments and Studies
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
Central Drug Research Institute
2015-2025
Ministry of AYUSH
2023-2024
Government of India
2023-2024
Central Council for Research in Ayurvedic Science
2023-2024
Amity University
2022-2024
University of Delhi
2024
Narendra Dev University of Agriculture and Technology
2024
Washington University in St. Louis
2024
Indian Institute of Technology Kanpur
2023
Creative Commons
2023
Abstract Biomaterials play a vital role in targeting therapeutics. Over the years, several biomaterials have gained wide attention treatment and diagnosis of diseases. Scientists are trying to make more personalized treatments for different diseases, as well discovering novel single agents that can be used prognosis, medication administration, keeping track how works. Theranostics based on nano-biomaterials higher sensitivity specificity disease management than conventional techniques. This...
A series of pyrazolo(dihydro)pyridines was synthesized and evaluated for antileishmanial efficacy against experimental visceral leishmaniasis (VL). Among all compounds, 6d 6j exhibited better activity than miltefosine intracellular amastigotes. Compound (50 mg/kg/day) further studied Leishmania donovani/BALB/c mice via the intraperitoneal route 5 days displayed >91 >93% clearance splenic liver parasitic burden, respectively. Combination treatment with a subcurative dose (5 mg/kg) in BALB/c...
In the past decade, metal-free approaches for C–C bond formation have attracted a great deal of attention due to their ease use and low cost. This report represents novel synthesis 3,3′-bisimidazopyridinylmethanes via intermolecular oxidative C(sp2)–H functionalization imidazo[1,2-a]pyridines with dimethyl sulfoxide as carbon synthon (CH2) using H2O2 mild oxidant under air. A library 3,3′-bis(2-arylimidazo[1,2-a]pyridin-3-yl)methanes has been achieved in good excellent yields. The present...
Abstract Carbon has always found a spotlight in human life either the form of graphite, diamonds, activated charcoal, carbon nanotubes, or dots (CDs). quantum (CQDs) CDs became centre attraction because their potential applications biomedical field such as bio‐imaging, drug nanocarriers, gene therapeutics, photosensitizing agents, theranostics and provides other multifunctional diagnostic platforms. There are numerous advantages due to biocompatibility, reduced toxicity, water‐solubility,...
An environmentally benign protocol for the synthesis of<italic>N</italic>-(pyridine-2-yl)amides from aldehydes and 2-aminopyridines has been developed under mild conditions.
A phenyliodine(III) diacetate (PIDA)-mediated, highly efficient and tandem approach for the synthesis of aryldiazenylisoxazolo(isothiazolo)arenes from simple 2-amino-N′-arylbenzohydrazides has been developed. The reaction proceeds via formation (E)-(2-aminoaryl)(aryldiazenyl)methanone as key intermediate, followed by intramolecular oxidative O–N/S–N bond in one pot at room temperature. quiet different reactivity substrate is due to a diazo intermediate which encounters nucleophilic attack...
Millets are a group of small-seeded grains cultivated for centuries as staple food crops in many parts the world. In recent years, there has been growing interest millet due to its exceptional nutritional and health benefits. rich essential nutrients such proteins, dietary fiber, vitamins, minerals, antioxidants. They also gluten-free have low glycemic index, making them suitable individuals with gluten intolerance or diabetes. Studies shown that regular consumption can contribute several...
Abstract Cancer remains a major global health burden, necessitating innovative approaches for improved diagnosis and treatment. Aptamer-based theranostics have gained attention in the field of cancer research Aptamers can be used as targeting ligands delivery therapeutic agents to cells, well detection imaging cancer, due high binding affinity selectivity. are also being investigated anticancer drugs. Specifically, aptamers serve tool controlling protein activity via protein-protein...
Understanding the function of conserved hypothetical protein (CHP)s expressed by a pathogen in infected host can lead to better understanding its pathogenesis. The present work describes functional characterization CHP, Rv1717 Mycobacterium tuberculosis (Mtb). has been previously reported be upregulated TB patient lungs. belongs cupin superfamily functionally diverse proteins, several them being carbohydrate handling proteins. Bioinformatic analysis amino acid sequence revealed similarity...
The present study delves into the evolution of traditional Ayurvedic oil preparations through innovative strategies to develop advanced gel formulations, aiming at amplifying their therapeutic efficacy. oils have a rich historical context in healing practices, yet conversion contemporary gel-based formulations represents revolutionary approach augment medicinal potential. primary objective this transformation is leverage scientific advancements and modern pharmaceutical techniques enhance...
Lesions and stable secondary structures in mRNA severely impact the translation efficiency, causing ribosome stalling collisions. Prokaryotic ribosomal proteins Rps3, Rps4 Rps5, located entry tunnel, form helicase center unwind during translation. However, mechanism underlying detection of lesions on translating is unclear. We used Cryo-EM, biochemical assays, knockdown experiments to investigate apurinic/apyrimidinic (AP) endoribonuclease activity bacterial ribosomes AP-site containing...
A transition-metal-free, substrate selective synthesis of 2,3-diaryl indoles, 4-hydrazono-tetrahydroquinolines and substituted quinolines has been developed.
Herbal medicine has become a medicinal as well the economic aspect of global significance. While use these herbal medicines increased, there are several questions about their consistency, protection, and effectiveness in different countries. Boswellic acid (BA) is one active constituents obtained from plant Boswellia serrata (BS) family Burseraceae. The oleoresin gum also known Salai guggul, Indian olibanum, or frankincense. species comprises variety phytochemical components, essential oil,...
Abstract Objectives Present report evaluates the protective effect of geraniol on high fat diet (HFD) induced obesity in rats and also determines molecular mechanism it. Methods Rats were with administration HFD for four weeks 200 400 mg/kg p.o. was administered next week respective groups. Blood glucose oral tolerance test (OGTT), lipid profile estimated treated rats. Moreover, docking study performed to determine specific by targeting HMG-CoE A reductase (in silico). Results There...