A5089133830- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Extracellular vesicles in disease
- Disaster Response and Management
- Cannabis and Cannabinoid Research
- Fluorine in Organic Chemistry
- Chemical Synthesis and Analysis
- Metabolism and Genetic Disorders
- MicroRNA in disease regulation
- Alcohol Consumption and Health Effects
- Forensic Toxicology and Drug Analysis
- Respiratory Support and Mechanisms
- Yersinia bacterium, plague, ectoparasites research
- Diet and metabolism studies
- RNA Interference and Gene Delivery
- Pharmacological Effects of Natural Compounds
- Carbohydrate Chemistry and Synthesis
- RNA regulation and disease
- Bacterial Genetics and Biotechnology
- Emergency and Acute Care Studies
- Cell Adhesion Molecules Research
- Sleep and Work-Related Fatigue
Umeå University
2015-2025
ABSTRACT Histones are conserved nuclear proteins that function as part of the nucleosome in regulation chromatin structure and gene expression. Interestingly, extracellular histones populate biofluids from healthy individuals, when elevated, may contribute to various acute chronic diseases. It is generally assumed most exist nucleosomes, components chromatin. We analysed cell culture models under normal stressed conditions identify pathways histone secretion. report core linker localize...
Increased endocannabinoid tonus by dual-action fatty acid amide hydrolase (FAAH) and substrate selective cyclooxygenase (COX-2) inhibitors is a promising approach for pain-relief. One such compound with this profile 2-(2-fluorobiphenyl-4-yl)-N-(3-methylpyridin-2-yl)propanamide (Flu-AM1). These activities are shown Flu-AM1 racemate, but it not known whether its two single enantiomers behave differently, as the case towards COX-2 parent flurbiprofen enantiomers. Further, effects of upon...
ABSTRACT Histones are conserved nuclear proteins that function as part of the nucleosome in regulation chromatin structure and gene expression. Interestingly, extracellular histones populate biofluids from healthy individuals when elevated may contribute to various acute chronic diseases. It is generally assumed most exist nucleosomes, components chromatin. We analysed cell culture models under normal stressed conditions identify pathways histone secretion. report core linker localize...
The Gram-negative enteropathogen Yersinia pseudotuberculosis possesses a number of regulatory systems that detect cell envelope damage caused by noxious extracytoplasmic stresses. CpxA sensor kinase and CpxR response regulator two-component system is one such pathway. Active Cpx signalling upregulates various factors designed to repair restore integrity. Concomitantly, this pathway also down-regulates key determinants virulence. In Yersinia, cpxA deletion accumulates high levels...
Abstract Objective To examine if atrial fibrillation at the time of emergency transport to tertiary care hospital by air ambulance is associated with increased mortality risk. Design Retrospective cohort study. Logistic regression and Cox were used assess associations condition outcome (mortality). Propensity score matching (1:1) was identify comparison cases. Setting One centre in sparsely populated northern Sweden Participants Critical cases undergoing emergent fixed-wing healthcare region...
Objectives To test if impaired oxygenation or major haemodynamic instability at the time of emergency intensive care transport, from a smaller admitting hospital to tertiary centre, are predictors long-term mortality. Design Retrospective observational study. Impaired was defined as oxyhaemoglobin %–inspired oxygen fraction ratio (S/F ratio)<100. Major need for treatment with norepinephrine infusion sustain mean arterial pressure (MAP) above 60 mm Hg having MAP <60. Logistic regression...
ObjectiveWe assessed the mortality risk related to time for intensive care unit transport in a geographically large regional health system.MethodsPatient-level data from critical ambulance missions were analyzed 2,067 cases, mission time, and relevant patient factors. Mission was used as surrogate "distance" tertiary care, at 7 days other intervals assessed.Results: No increased found an unadjusted regression analysis (odds ratio = 1.00; range, 0.999-1.002; P .66). In secondary analysis,...
Abstract Background We aimed to test if impaired oxygenation or major hemodynamic instability at the time of emergency intensive care transport between hospitals are predictors long-term mortality. Methods From a regional hospital research database, study cohort was identified as those cases transported in fixed-wing air ambulance from outlying tertiary center during 2000–2016 for adults (16 years old older). Impaired defined oxyhemoglobin % - inspired oxygen fraction ratio (S/F ratio) <...