A5004900854- Cancer and Skin Lesions
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chromatin Remodeling and Cancer
- Sarcoma Diagnosis and Treatment
- Urologic and reproductive health conditions
- Prostate Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Cardiac tumors and thrombi
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Prostate Cancer Treatment and Research
- Neurofibromatosis and Schwannoma Cases
- Glioma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Cardiovascular Effects of Exercise
- Brain Metastases and Treatment
- Cardiac Structural Anomalies and Repair
- Ear and Head Tumors
- Inflammatory Biomarkers in Disease Prognosis
- Peptidase Inhibition and Analysis
- Bladder and Urothelial Cancer Treatments
- Pancreatitis Pathology and Treatment
- Histiocytic Disorders and Treatments
Gifu University
1997-2024
Gifu University Hospital
2014-2024
Asahi University
2014
Mizuho (Japan)
2014
Modifying effects of diallyl disulfide (DAD), aspirin or DL‐α‐difluoromethylornithine (DFMO) on 2‐amino‐l‐methyl‐6‐phenyIimidazo[4,5‐b]pyridine (PhlP)‐induced mammary carcinogenesis in SD rats were investigated. A total 166 female rats, 6 weeks old, divided into 8 groups. They fed a high fat diet throughout the experiment. Starting at 7 age, groups 1–4 given PhIP (85 rag/kg body weight corn oil) by gavage times 10 days, and 58 oil alone. For beginning 4 weeks, 2 5 DAD 200 ppm diet. Similarly...
This study aimed to evaluate the efficacy of magnetic resonance (MR) imaging in differentiating between cutaneous basal cell carcinoma (cBCC) and squamous (cSCC) head neck region.Among patients with cancers, 14 primary cBCCs 15 cSCCs a histologic tumor height ≥ 4 mm underwent MR examinations; findings were then examined for correlations.cBCCs (71%) occurred more frequently on nose than (13%) (p < 0.01). The maximum diameter (23.5 ± 7.2 vs. 12.7 4.5 mm; p 0.01) diameter-to-height ratio (2.8...
Combined hepatocellular cholangiocarcinoma is a rare and challenging primary liver malignancy that lacks any established standard treatments for unresectable cases. We herein present the first known case of 49-year-old woman diagnosed with combined hepatocellular-cholangiocarcinoma, who underwent novel chemotherapy involving durvalumab plus tremelimumab combination therapy. The treatment was temporarily discontinued owing to immune-related adverse events, such as rash, patient subsequently...
There has been no clinically useful diagnostic or prognostic biomarker for renal cell carcinoma (RCC). Serum γ-glutamyltransferase (GGT) activity reported to be a marker several types of cancer including RCC. Exosomes small extracellular vesicles present in body fluids have potential as biomarker. We recently demonstrated that GGT on exosomes isolated from serum is the differential diagnosis prostate and benign hyperplasia. In this study, we aimed examine if exosomal could RCC.We examined...
<b><i>Background:</i></b> The characteristics of <i>Helicobacter pylori</i> (HP) infection-negative gastric cancer (HPINGC) have not been well documented because the rareness. aim this study was to classify HPINGC endoscopically and clinicopathologically. <b><i>Methods:</i></b> This retrospective included 1,741 early lesions evaluated their HP infection status. Expression levels MUC5AC, MUC6, MUC2, CD10, p53, MIB-1, pepsinogen-I,...
Evidence regarding intraductal papillary neoplasm of the bile duct (IPNB) as a type precancerous lesion cholangiocarcinoma is limited. Moreover, reproducible in vivo model lacking, and IPNB pathogenesis remains unclear. Here, we use doxycycline-inducible tetracycline (Tet)-on mice to control fibroblast growth factor 10 (FGF10) expression, which regulates branching tubule formation. FGF10-induced mimics multifocal divergent human phenotypes via FGF10-FGF receptor 2...
The purpose of this study was to evaluate computed tomography and magnetic resonance imaging benign trichilemmal cysts proliferating tumours.Nineteen histologically confirmed cutaneous lesions with keratinisation (12 seven tumours) were enrolled. Among them, 10 (six four examined by tomography, while 13 (eight five imaging. Computed characteristics retrospectively reviewed.Sixteen (84%, six occurred on the scalp. Lobulated margins observed in (26%, three two tumours). With respect...
This study aimed to evaluate imaging findings of cutaneous angiosarcoma (cAS) the scalp compared with those squamous cell carcinoma (cSCC).This included 15 patients primary cAS and 10 cSCC scalp. Seven eight underwent magnetic resonance imaging, 11 18F-fluorodeoxyglucose-positron emission tomography/computed tomography imaging. Imaging for both pathologies were retrospectively reviewed compared.All cases elevated lesions an obtuse angle, invading subcutaneous fat tissue. Multiple observed in...
This study aimed to determine the predictive value of Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) based on biparametric magnetic resonance imaging (bpMRI) with combined target biopsy (TBx) systematic (SBx) in patients suspicion having clinically significant prostate cancer (csPCa). In this retrospective study, we reviewed clinical pathological records 184 consecutive who underwent bpMRI before biopsy. We focused PI-RADS v2 scores ≥ 3. MRI was performed using a 3-Tesla...
Background— Extravascular smooth muscle cells are often observed in the endocardium of human failing hearts. Here, we characterized phenotype those and investigated their physiological significance. Methods Results— We examined left ventricular biopsy specimens obtained from 44 patients with dilated cardiomyopathy 6 nonfailing In Masson trichrome–stained histological preparations, bundles were seen localized 23 (none controls). These immunopositive for α-smooth actin, type 2 myosin, desmin,...
This study aimed to assess the efficacy of MRI for differentiating between uterine submucosal polypoid adenomyomas (PAs) and endometrial polyps (EPs).MRI was used examine 40 histopathologically confirmed benign tumors (8submucosal PAs 32 EPs). Atypical were excluded from this study. Quantitative measurements (maximum tumor diameter, maximum cyst number cysts, apparent diffusion coefficient values) qualitative imaging findings (predominance cystic or solid components as well presence...
Serrated lesions in the colorectum are currently predominantly classified as hyperplastic polyps (HPs), sessile serrated adenomas/polyps (SSA/Ps), and traditional adenomas (TSAs) according to their morphology. However, histological morphology molecular changes still unclear. We performed immunohistochemistry for Ki67, p16INK4a, WNT5A human HPs (n=22), SSA/Ps (n=41), TSAs (n=19). The distribution of Ki67 p16INK4a positive cells was different from that SSA/Ps. Co-expression P16INK4a infrequent...
This study aimed to assess the efficacy of imaging findings when differentiating between human papillomavirus (HPV)-positive and -negative squamous cell carcinomas (SCCs) maxillary sinus.This included 37 patients with histopathologically immunohistochemically confirmed SCCs sinus (three HPV positive 34 negative). Apparent diffusion coefficients (ADCs), MR signal intensities, CT findings, maximum standardized uptake (SUVmax) were correlated two pathologies.The minimum ADC (ADCmin) was...
A 26-year-old woman with gross hematuria was seen in a previous hospital. Magnetic resonance imaging (MRI) showed tumor at the dome of urinary bladder invasion outside wall. The patient underwent transurethral resection (TUR-BT). From result pathological examination, suggested to be carcinosarcoma bladder. then referred our hospital for treatment. We performed radical cystectomy and ileal conduit diversion. Pathological examination excised specimen revealed an inflammatory myofibroblastic as...