A5004796468- Breast Cancer Treatment Studies
- Prostate Cancer Treatment and Research
- Statistical Methods in Clinical Trials
- Prostate Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Gene expression and cancer classification
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- Colorectal Cancer Treatments and Studies
- HER2/EGFR in Cancer Research
- Molecular Biology Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- BRCA gene mutations in cancer
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal Cancer Screening and Detection
- Statistical Methods and Bayesian Inference
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Analytical Methods in Pharmaceuticals
- Cytomegalovirus and herpesvirus research
- Meta-analysis and systematic reviews
- Cancer, Lipids, and Metabolism
Exact Sciences (United States)
2020-2024
Genomic Health (United States)
2012-2021
Tel Aviv University
2021
Montefiore Medical Center
2021
Dana-Farber Cancer Institute
2021
Rabin Medical Center
2021
Albert Einstein College of Medicine
2021
NRG Oncology
2021
Cleveland Clinic
2012
Providence Saint Joseph Medical Center
2011
Aims The anti-anginal efficacy and safety of ranolazine in diabetic non-diabetic patients included the Combination Assessment Ranolazine In Stable Angina (CARISA) trial (JAMA 2004;291:309) were studied. Glycaemic control was also assessed CARISA its long-term open-label extension study.
The 21-gene breast cancer assay recurrence score (RS) is widely used for assessing risk and predicting chemotherapy benefit in patients with estrogen receptor (ER) -positive cancer. Pathologic clinical factors such as tumor size, grade, patient age also provide independent prognostic utility. We developed a formal integration of these measures evaluated its predictive value.
The NSABP B-20 prospective-retrospective study of the 21-gene Oncotype DX Breast Cancer Recurrence Score® test predicted benefit from addition chemotherapy to tamoxifen in node-negative, estrogen-receptor positive breast cancer when recurrence score (RS) was ≥31. HER2 is a component RS algorithm with coefficient and contributes higher values. Accrual occurred prior routine testing for HER2, so questions have arisen regarding assay performance if HER2-positive patients were identified...
ABSTRACT The impact of cytomegalovirus (CMV) on human immunodeficiency virus type 1 (HIV-1) disease progression has been controversial. In this study, we sought to determine if CMV viral load is independent HIV-1 in predicting and survival. Our findings indicate that patients with advanced AIDS, DNA an marker survival more predictive than RNA load. Moreover, who respond preemptive therapy oral ganciclovir, resulting undetectable levels DNA, their plasma, have a significantly lower risk...
High-dose aspirin therapy for rheumatoid arthritis is frequently associated with severe gastrointestinal injury. To explore the possibility of reversing such damage, we conducted a double-blind, multicenter study misoprostol, prostaglandin E1 analog, which has demonstrated mucosal protective, gastric antisecretory, and ulcer healing properties. We also studied possible interference misoprostol continuing treatment in management patients arthritis. Patients confirmed endoscopically documented...
Journal Article A Randomized, Controlled Study of Intravenous Ganciclovir Therapy for Cytomegalovirus Peripheral Retinitis in Patients with AIDS Get access Stephen A. Spector, Spector Reprints or correspondence: Dr. University California, San Diego, Clinical Sciences Building, 9500 Gilman Dr., Mail Code 0672, La Jolla, CA 92093. Search other works by this author on: Oxford Academic PubMed Google Scholar Thomas Weingeist, Weingeist Richard B. Pollard, Pollard Douglas T. Dieterich, Dieterich...
RNA biomarkers discovered by RT-PCR-based gene expression profiling of archival formalin-fixed paraffin-embedded (FFPE) tissue form the basis for widely used clinical diagnostic tests; however, RT-PCR is practically constrained in number transcripts that can be interrogated. We have developed and optimized RNA-Seq library chemistry as well bioinformatics biostatistical methods whole transcriptome from FFPE tissue. The accommodates low inputs sample multiplexing. These both enable rediscovery...
Better tools are needed to estimate local recurrence (LR) risk after breast-conserving surgery (BCS) for DCIS. The DCIS score (DS) was validated as a predictor of LR in E5194 and Ontario cohort (ODC) BCS. We combined data from ODC adjusting clinicopathological factors provide refined estimates the 10-year treatment by BCS alone. Data were combined. Patients with positive margins or multifocality excluded. Identical Cox regression models fit each study. Patient-specific meta-analysis used...
The 17-gene Oncotype DX Genomic Prostate Score (GPS) test predicts adverse pathology (AP) in patients with low-risk prostate cancer treated immediate surgery. We evaluated the GPS as a predictor of outcomes multicenter active surveillance cohort.Diagnostic biopsy tissue was obtained from men enrolled at 8 sites Canary Active Surveillance Study. primary endpoint AP (Gleason Grade Group [GG] ≥ 3, pT3a) who underwent radical prostatectomy (RP) after initial surveillance. Multivariable...
Analysis of covariance (ANCOVA) techniques are often employed in the analysis clinical trials to try account for effects varying pretreatment baseline values an outcome variable on posttreatment measurements same variable. Baseline variables typically random variables, which violates usual ANCOVA assumption that covariate fixed. Therefore, hypothesis tests treatment may be invalid, and slope parameter estimator biased, this application. We show, however, if - have a bivariate normal...
To assess the association between Oncotype DX Genomic Prostate Score (GPS) result and long-term oncological outcomes following radical prostatectomy (RP).We evaluated of GPS assayed from index lesion RP tissue with risk distant metastases (DM) prostate cancer-specific mortality (PCSM) over 20 years in a stratified cohort sample 428 patients 2,641 treated 1987 2004. Cox regression cause-specific hazards was used to estimate absolute both end points, death other causes as competing risk. A...
This analysis examined the safety and efficacy of extended‐release ranolazine among patients aged 70 years or older (n=363) compared with younger than (n=1024) enrolled in 2 large multinational prospective clinical trials. The primary end points were exercise capacity number weekly angina episodes. Beneficial effects ranolazine, relative to placebo, generally similar for each these outcomes participants. For example, at a dose 1000 mg bid, mean duration increased by 19.8±13.1 seconds (mean ±...
Abstract Background The United States Food and Drug Administration recently approved a Ki-67 immunohistochemistry (IHC) assay to identify patients with early breast cancer at high disease recurrence risk. Oncotype Dx Breast Recurrence Score® has been validated in hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2−) invasive (IBC) predict chemotherapy benefit distant risk, regardless of nodal status. This study assessed the correlation between (RS)...
Abstract Background: The Clinical Treatment Score at 5 years (CTS5) is a prognostic tool using clinicopathological parameters (nodal status, tumor size, grade, and age) to estimate distant recurrence (DR) risk after of endocrine treatment for postmenopausal women with estrogen receptor (ER) positive breast cancer. It was developed validated in the ATAC BIG 1-98 trials. Here, we evaluate whether CTS5 who were free adjuvant participated TAILORx study. Methods: 10273 ER-positive, HER2-negative,...
509 Background: The 21-gene Oncotype DX Recurrence Score (RS) is widely used for assessment of recurrence risk and prediction chemotherapy benefit in patients with early stage ER-positive breast cancer. Pathologic clinical factors such as tumor size grade, patient age also provide independent prognostic utility might be combined the RS to achieve more power. Methods: All NSABP trial B-14 ATAC study who had specimens successful assay were included. node-negative treated tamoxifen....
Abstract Analyses intended to identify genes with expression that is associated some clinical outcome or state are often based on ranked p ‐values from tests of point null hypotheses no association. Van de Wiel and Kim take the innovative approach testing interval degree association for a gene less than value interest against alternative it greater. Combining this idea false discovery rate controlling methods Storey, Taylor Siegmund gives computationally simple way true (TDRDA) sets among...
To assess the association of adverse pathology (AP), defined as high-grade (≥ Gleason Grade Group 3) and/or non-organ confined disease, with long-term oncologic outcomes after radical prostatectomy (RP).Using a stratified cohort sampling design, we evaluated AP risk distant metastasis (DM) and prostate cancer-specific mortality (PCSM) up to 20 years RP in 428 patients treated between 1987 2004. Cox regression cause-specific hazards was used estimate absolute both endpoints, death from other...
We propose a method for assessing an individual patient's risk of future clinical event using trial or cohort data and Cox proportional hazards regression, combining the information from several studies meta-analysis techniques. The combines patient-specific estimates log cumulative hazard across studies, weighting by relative precision estimates, either fixed- random-effects calculations. Risk assessment can be done any patient few key summary statistics determined once all each study....