A5078565461- Aortic aneurysm repair treatments
- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Infectious Aortic and Vascular Conditions
- Aortic Disease and Treatment Approaches
- Cerebrovascular and Carotid Artery Diseases
- Vascular anomalies and interventions
- Diagnosis and Treatment of Venous Diseases
- Abdominal vascular conditions and treatments
- Central Venous Catheters and Hemodialysis
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Protein Degradation and Inhibitors
- Venous Thromboembolism Diagnosis and Management
- Biliary and Gastrointestinal Fistulas
- Hemodynamic Monitoring and Therapy
- Cardiovascular Health and Disease Prevention
- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Pancreatitis Pathology and Treatment
- Renal and Vascular Pathologies
- Kawasaki Disease and Coronary Complications
- Intracranial Aneurysms: Treatment and Complications
- Cardiac tumors and thrombi
University of Virginia
2020-2024
The University of Tokyo
2013-2024
The University of Texas Medical Branch at Galveston
2023
Albert Einstein College of Medicine
2023
Takara (Japan)
2023
University of Virginia Health System
2021-2023
Morinomiya Hospital
2022-2023
Asahi General Hospital
2017-2022
Nationwide Children's Hospital
2022
The Ohio State University
2020
There is no consensus regarding the terminology, definition, classification, diagnostic criteria, and algorithm, or reporting standards for disease of infective native aortic aneurysm (INAA), previously known as mycotic aneurysm. The aim this study was to establish by performing a study.The Delphi methodology used. Thirty-seven international experts were invited via mail participate. Four two week rounds performed, using an online questionnaire, initially with 22 statements nine items....
Several drugs targeting the pathogenesis of aortic aneurysm have shown efficacy in model systems but not clinical trials, potentially owing to lack targeted drug delivery. Here, we designed a novel delivery system using nanoparticles target disrupted micro-structure. We generated poly(ethylene glycol)-shelled incorporating rapamycin that exhibited uniform diameter and long-term stability. When injected intravenously into rat which abdominal (AAA) had been induced by infusing elastase,...
Abdominal aortic aneurysm (AAA) is a progressive dilatation, causing ∼80% mortality upon rupture. Currently, there no approved drug therapy for AAA. Surgical repairs are invasive and risky thus not recommended to patients with small AAAs which, however, account ∼90% of the newly diagnosed cases. It therefore compelling unmet clinical need discover effective non-invasive strategies prevent or slow down AAA progression. We contend that first will only arise through discoveries both targets...
This Delphi study established a consensus document on infective native aortic aneurysm regarding overall management, surgical and antimicrobial treatment, follow up routines, duration of as well defining cure the disease.This was in order to support clinicians researchers dealing with this rare disease where evidence is lacking guide detailed supplement current guidelines.
The Global Limb Anatomic Staging System (GLASS) has been widely used to evaluate patients with chronic limb-threatening ischemia (CLTI). As end-stage kidney disease (ESKD) is a well-known CLTI risk factor, we aimed determine whether on hemodialysis (HD) have worse limb prognosis than those without ESKD, considering the same GLASS background.
From 2001 to 2012, arterial reconstruction was performed in 306 out of 497 limbs (62%) with critical limb ischemia. The reasons for non-vascularization include high operative risk (36%), extended necrosis or infection (20%), and technical issues (15%). Cumulative patency salvage collagen disease were significantly worse compared arteriosclerosis obliterans. salvage, amputation free survival (AFS), major adverse event perioperative death (MALE + POD) patients end-stage renal (ESRD) without...
To determine the midterm outcomes of distal bypass surgery for very elderly patients, and to ideal candidates this procedure.Of 268 consecutive patients (328 limbs) with critical limb ischemia who were treated between 2006 2013, 106 (126 underwent retrospectively reviewed. Nineteen (22 aged ≥80 years (very group) 87 (104 <80 (control group).The baseline characteristics differed 2 groups in terms regular hemodialysis rate group, 4 [21%] vs control 60 [69%]; P = .0002) Charlson comorbidity...
Some patients with critical limb ischemia (CLI) lack symptoms of intermittent claudication (IC) before the onset CLI. We studied outcome such patients, because this is currently unknown. METHODS AND RESULTS: For retrospective exploratory analysis, we divided 225 (265 limbs) CLI into 2 groups: 142 (172 without a history IC (non-IC group) and 83 (93 (IC group). examined comorbid factors found that higher proportion in non-IC group failed to undergo arterial revascularization (49% vs. 20%,...
Neointimal hyperplasia/proliferation (IH) is the primary etiology of vascular stenosis. Epigenomic studies concerning IH have been largely confined to in vitro models, and IH-underlying epigenetic mechanisms remain poorly understood. This study integrates information from vivo epigenomic mapping, conditional knockout, gene transfer pharmacology rodent models IH. The data injured (IH-prone) rat arteries revealed a surge genome-wide occupancy by histone-3 lysine-27 trimethylation (H3K27me3),...
It has been reported that median arcuate ligament syndrome is closely associated with gastric or pancreaticoduodenal artery aneurysms. Hemodynamic state plays an important role in the formation of These aneurysms are treated open resection endovascular exclusion. However, whether revascularization celiac can prevent aneurysm unknown. This report indicated a possibility prophylactic for stenosis resulted decreased shear stress on collaterals, which may otherwise be susceptible to new...
Abstract Neointimal hyperplasia (IH) is a common vascular pathology that typically manifests in in-stent restenosis and bypass vein graft failure. Smooth muscle cell (SMC) phenotypic switching central to IH, both regulated by some microRNAs, yet the role of miR579-3p, scarcely studied microRNA, not known. Unbiased bioinformatic analysis suggested miR579-3p was repressed human primary SMCs treated with different pro-IH cytokines. Moreover, software-predicted target c-MYB KLF4 − two master...
To analyze the effects of total side branch embolization at endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms on incidences persistent type 2 endoleak (pT2EL), changes in sac diameter, and reintervention.
Since endovascular aneurysm repair has become predominant, the issue of training young vascular surgeons in open abdominal aortic (AAA) surgery received significant attention. Through learning curve analysis, we aimed to determine number cases needed for achieve satisfactory surgical skills.