A5013529367- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- Animal Disease Management and Epidemiology
- Fire effects on ecosystems
- Vector-Borne Animal Diseases
- Salmonella and Campylobacter epidemiology
- Virology and Viral Diseases
- Influenza Virus Research Studies
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Suicide and Self-Harm Studies
- Transgenic Plants and Applications
- Animal Nutrition and Physiology
- Gun Ownership and Violence Research
- RNA Interference and Gene Delivery
- Posttraumatic Stress Disorder Research
- Immune Response and Inflammation
- Viral Infectious Diseases and Gene Expression in Insects
- Antimicrobial Resistance in Staphylococcus
- Plant Virus Research Studies
- Immunotherapy and Immune Responses
- Evolution and Genetic Dynamics
- CRISPR and Genetic Engineering
- Veterinary medicine and infectious diseases
UK Health Security Agency
2023-2025
South Carolina Department of Health and Environmental Control
2024
Public Health England
2020-2022
Oxford Brookes University
2020-2022
Centers for Disease Control and Prevention
2020
Animal and Plant Health Agency
2013-2014
Nipah virus (NiV) is one of a group highly pathogenic viruses classified within the Henipavirus genus. Since 2012 at least 11 new henipa-like have been identified, including from locations and reservoir hosts; pathogenicity these has yet to be determined, but two them associated with morbidity, fatalities. The efficacy cross-reactivity vaccine candidates derived soluble glycoproteins both NiV Hendra (HeV) was evaluated in our recently established hamster model. Both preparations resulted...
Dengue virus (DENV) is an emerging threat causing estimated 390 million infections per year. Dengvaxia, the only licensed vaccine, may not be adequately safe in young and seronegative patients; hence, development of a safer, more effective vaccine great public health interest. Virus-like particles (VLPs) are very efficient strategy, DENV VLPs have been produced various expression systems. Here, we describe production Nicotiana benthamiana using transient expression. The co-expression...
The pathogenesis and host-viral interactions of the Crimean–Congo hemorrhagic fever orthonairovirus (CCHFV) are convoluted not well evaluated. Application multi-omics system biology approaches, including biological network analysis in elucidating complex response, interrogates viral pathogenesis. present study aimed to fingerprint system-level alterations during acute CCHFV-infection cellular immune responses productive CCHFV-replication vitro. We used system-wide network-based peripheral...
Nipah virus (NiV) is recognized as one of the key pathogens with pandemic potential. We have recently established a NiV hamster model, which reproduces highly similar disease to that observed in human cases, including respiratory and neurological signs lesions. The aims this study were describe microscopic lesions golden Syrian model after intranasal (IN) intraperitoneal (IP) inoculation different doses Malaysian strain NiV; depth cell composition pulmonary brain expression proinflammatory...
Background: Old World orthohantaviruses are the aetiological agent of Haemorrhagic Fever with Renal Syndrome (HFRS) disease. Worldwide, two most prominent pathogens HFRS Seoul orthohantavirus (SEOV) and Hantaan (HTNV). There is currently no specific treatment nor widely licensed vaccine form hantaviruses. Methods: This study developed a virus-vectored approach using modified vaccinia Ankara (MVA) incorporating SEOV-HTNV chimeric nucleoprotein antigen. Results: The demonstrated induction...
Crimean-Congo haemorrhagic fever (CCHF) is the most widespread tick-borne viral affecting humans, and yet a licensed drug against virus (CCHFV) still not available. While several studies have suggested efficacy of ribavirin CCHFV, current literature remains inconclusive. In this study, we utilised next-generation sequencing to investigate mutagenic effect on CCHFV genome during clinical disease. Samples collected from CCHF patients receiving treatment or supportive care only at Sivas...
Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen causing disease in livestock and humans. Whilst initially restricted to the African continent, recent spread Arabian Peninsula has highlighted likelihood of entry into new regions. Due absence regulatory-approved human vaccine, work ongoing develop assess countermeasures. As such, small animal models play pivotal role providing information on pathogenesis elucidating which intervention strategies confer protection. To...
Egg-related outbreaks of salmonellosis are a significant health concern. Although Salmonella Enteritidis (SE) is the major egg-associated serotype, Typhimurium (ST) can also infect hen's reproductive tract and contaminate eggs. Recently, monophasic aphasic variants ST have been reported with increased frequency in Europe, isolation these from laying flocks triggers same legislative restrictions associated biphasic strains. However, little known about colonization, invasiveness persistence...
Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is spread by infected ticks or direct contact with blood, tissues and fluids from patients livestock. Infection CCHFV causes severe haemorrhagic fever in humans which fatal up to 83 % of cases. listed as a priority pathogen the World Health Organization (WHO) there are currently no widely-approved vaccines. Defining serological correlate protection against infection would support development vaccines providing 'target threshold' for pre-clinical...
Scholars continue to unpack the negative impact(s) COVID-19 pandemic has on Americans' lives. Those experiencing adverse experiences during childhood may have been disproportionately at greater risk of victimization pandemic. As mental health deteriorated and firearm violence increased in early stages pandemic, public become more aware receptive seeking counseling restrictive policies. Utilizing an original statewide survey distributed across state South Carolina, we first test whether those...
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus causing debilitating febrile illness with rheumatic disease symptoms of arthralgia and arthritis. Since its spread outside Africa in 2005, it continues to cause outbreaks disseminates into new territories. Intervention strategies are urgently required, including vaccination antiviral approaches. To test efficacy, the use small animal models required. Two mouse strains, A129, deficiency their type-I interferon (IFN) receptor, C57BL/6...
Background: Avian influenza viruses (AIVs) are a significant public health and agricultural concern in Bangladesh. The human population typically lacks immunity to most of these viruses, posing pandemic threat. Since 2007, AIVs have been identified live bird markets This study aimed detect the AIV subtypes H5, H7, H9 pet (PBMs) Methods materials: We conducted surveillance six largest PBMs Dhaka during 2014 2015. visited every two weeks collected paired swabs (cloacal or oropharyngeal) fecal...
Abstract The pathogenesis and host-viral interactions of the Crimean–Congo hemorrhagic fever orthonairovirus (CCHFV) are convoluted not well evaluated. Application multi-omics system biology approaches including biological network analysis in elucidating complex response, allow for interrogating viral pathogenesis. present study aimed to fingerprint system-level alterations during acute CCHFV-infection cellular immune responses productive CCHFV-replication vitro . We used system-wide...
Background: On January 9th, 2017 a community health worker notified of increased number deaths in backyard poultry pig rearing village Rajshahi district, Bangladesh. We investigated the reported morbidity and mortality among to confirm there was an ongoing outbreak avian influenza, determine etiology, identify possible associated illnesses humans pigs. Methods materials: 10th, 2017, we discussed with villager's residents leaders, verify high influenza like illness cases occurred villages...
Humanised antibodies targeting Crimean-Congo Haemorrhagic virus (CCHFV) are needed for the development and standardisation of serological assays. These assays to address a shortfall in available tests that meet regulatory diagnostic standards aid surveillance activities extend knowledge on distribution CCHFV. To generate humanised monoclonal antibody against CCHFV, we have compared two methods: traditional mouse hybridoma approach with subsequent sequencing humanisation versus non-animal...
Abstract The pathogenesis and host-viral interactions of the Crimean–Congo hemorrhagic fever orthonairovirus (CCHFV) are convoluted is not well evaluated. To understand host immune responses against CCHFV, we have performed a global transcriptomic analysis peripheral blood mononuclear cells from longitudinal cohort CCHF patients who survived infection temporal untargeted proteomics CCHFV infected Huh7 cells. Our results indicate that during acute phase infection, host's metabolic...