A5049897667- Pharmacogenetics and Drug Metabolism
- Computational Drug Discovery Methods
- Biosimilars and Bioanalytical Methods
- Genetic Associations and Epidemiology
- Inflammatory mediators and NSAID effects
- Receptor Mechanisms and Signaling
- Hormonal Regulation and Hypertension
- Drug Transport and Resistance Mechanisms
- Animal Virus Infections Studies
- Malaria Research and Control
- RNA modifications and cancer
- Health Systems, Economic Evaluations, Quality of Life
- Eicosanoids and Hypertension Pharmacology
- Viral Infections and Immunology Research
- Research in Cotton Cultivation
- Lipid metabolism and biosynthesis
- Viral gastroenteritis research and epidemiology
University of Cape Town
2018-2024
Sefako Makgatho Health Sciences University
2017
South African Medical Research Council
2017
South Africa is one of 25 countries identified by the World Health Organization as having potential to eliminate malaria in near future. In response emerging threat antimalarial resistance, enhanced its surveillance programs enable mapping resistance markers prevalence down facility level. A total 4 471 samples, collected between January 2022 and August 2024 from healthcare facilities, during active malaria-geliminating districts KwaZulu-Natal Mpumalanga provinces, were assessed for drug...
Warfarin dose variability observed in patients is attributed to variation genes involved the warfarin metabolic pathway. Genetic CYP2C9 and VKORC1 has been traditional focus evaluating variability, with little on other genes.We set out evaluate 27 single nucleotide polymorphisms (SNPs) CYP2C cluster loci 8 (VKORC1, ABCB1, CYP2C9, CYP2C19, CYP2C8, CYP1A2, CYP3A4, CYP3A5) pharmacokinetics of warfarin.503 participants were recruited among black Africans Mixed Ancestry population groups, from...
Pharmacogenomics is universally relevant for worldwide modern therapeutics and yet needs further development in resource-limited countries. While there an abundance of genetic association studies controlled medical settings, a paucity with naturalistic design real-life clinical practice patients comorbidities under multiple drug treatment regimens. African are often burdened communicable noncommunicable comorbidities, the application pharmacogenomics settings remains limited. Using warfarin...
Coumarins such as warfarin are prescribed for prevention and treatment of thromboembolic disorders. Warfarin remains the most widely an anticoagulant choice in Africa. use is, however, limited by interindividual variability pharmacokinetics a narrow therapeutic index. The difference patients' pharmacodynamic responses to has been attributed genetic variation metabolism molecular targets (e.g., CYP2C9 VKORC1) host–environment interactions. This expert review offers synthesis human genetics...
Warfarin is a widely prescribed anticoagulant with narrow therapeutic index. The rs12777823G>A single-nucleotide polymorphism (SNP) in the CYP2C gene cluster has been shown to influence optimal warfarin doses African Americans. We report here effects of SNP on dose requirements two South population groups, black Africans (BA) and mixed ancestry (MA). A total 425 participants treatment were enrolled study. age group studied ranged between 44 66 years, 69% females enrolled. Genetic...
Childhood obesity is a growing public health burden in many countries. The lipid perilipin 1 (PLIN1) gene involved regulation of lipolysis, and thus represents viable candidate mechanism for genetics research children. In addition, the expression by circulating microRNAs (miRNAs) offers new venue diagnostic innovation. We report findings on associations among miRNAs, PLIN1 gene, susceptibility to childhood obesity. sample 135 unrelated subjects, 35 children with (between ages 3 13) 100...
Background: Warfarin is the most commonly used anticoagulant and exhibits a huge variability in starting doses required to achieve international normalised ratio (INR). Many genetic-association studies (GWAS) have reported on European Asian populations which has led designing of specific algorithms that are now being presented as universally applicable assisting decision making warfarin dosing. However, very few or no looked at pharmacogenetics African populations, yet, differences dosage...