Mehmet Akif Ovalı

ORCID: 0000-0002-3672-871X
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Research Areas
  • Circadian rhythm and melatonin
  • Birth, Development, and Health
  • Pregnancy and preeclampsia studies
  • Adipose Tissue and Metabolism
  • Diet, Metabolism, and Disease
  • Genetics, Aging, and Longevity in Model Organisms
  • Garlic and Onion Studies
  • Acute Kidney Injury Research
  • Adipokines, Inflammation, and Metabolic Diseases
  • Chemotherapy-induced organ toxicity mitigation
  • Diabetic Foot Ulcer Assessment and Management
  • Selenium in Biological Systems
  • Electrolyte and hormonal disorders
  • Hops Chemistry and Applications
  • Cardiovascular Syncope and Autonomic Disorders
  • Cassava research and cyanide
  • Air Quality and Health Impacts
  • Nitric Oxide and Endothelin Effects
  • Cardiac Arrest and Resuscitation
  • Obstructive Sleep Apnea Research
  • Ion Transport and Channel Regulation
  • Cardiac Ischemia and Reperfusion
  • Cancer, Hypoxia, and Metabolism
  • Medical and Biological Ozone Research
  • Airway Management and Intubation Techniques

Çanakkale Onsekiz Mart Üniversitesi
2014-2022

We investigated the gastroprotective effect of apricot kernel oil on ethanol induced gastric ulcer in rats. Male Wistar albino rats were divided into control, and + groups. The fatty acid composition was determined using GC-MS. A index defined as area percentage mucosa consisting ulcerated tissue. Gastric tissue by TUNEL staining for apoptosis, immunohistochemical iNOS staining, measurement IL-10 IL-6 expression ELISA assays catalase, malondialdehyde superoxide dismutase. group exhibited a...

10.1080/10520295.2018.1511064 article EN Biotechnic & Histochemistry 2018-09-20

Melatonin is a hormone secreted from the pineal gland and has different cardiovascular effects. KCNQ genes expressed in aorta related with vascu- lar tone KCNH2 gene characterised left ventricle associated QT duration. The aim of this study was to investigate effects melatonin on regulation blood pressure relationships between expressions KCNQ1-5, QTc interval. For that purpose, 42 male adult Sprague-Dawley rats were devided into six groups; SHAM, SHAM+L-NAME, PLT, PLT+L-NAME, PLT+MEL...

10.14715/cmb/2017.63.3.9 article EN cc-by Cellular and Molecular Biology 2016-03-31

The aim of this study was to explain the possible mechanisms by which melatonin deficiency results in cardiovascular injury and investigate effects administration on important signalling pathways element equilibrium thoracic aorta (TA). For purpose, we analysed cellular molecular or oxidative stress, DNA damage, chaperone response, apoptosis induction TA tissues pinealectomised rats using ELISA, RAPD, qRT-PCR, Western blot assays. showed that led an imbalance essential levels, unfolded...

10.1139/apnm-2018-0205 article EN Applied Physiology Nutrition and Metabolism 2018-07-30

In recent years, hyperbaric oxygen (HBO2) therapy has been considered as an effective method for the treatment of gentamicin (GM)-induced renal toxicity. However, findings related to use HBO2 GM toxicity are limited and contradictory. The aim this study is investigate protective role on GM-induced nephrotoxicity. For purpose, Wistar albino rats (n=28) were randomly divided into four equal groups: C, HBO2, GM+HBO2. (100 mg/kg, ip) applied over seven days. On eighth day blood kidney tissue...

10.22462/04.06.2019.5 article EN Undersea and Hyperbaric Medicine 2019-04-01

Objective This study aimed to investigate the effects of melatonin on cardiac oxidative stress and apoptosis in fetal heart RUPP rats.Methods The samples were obtained from administrated ratsResults Our results indicate that preeclampsia exacerbated by deficiency triggers hypoxic conditions, both mis/un-folded protein response, stress-induced DNA damage apoptosis. Melatonin treatment provided significant therapeutic hearts via regulating all these response at cellular molecular...

10.1080/10641955.2020.1802595 article EN Hypertension in Pregnancy 2020-08-14

AIM: We aimed to compare the effects of three different supraglottic airway devices, classic LMA, PLA, and V-gel, on hemodynamics QTc in rabbits under general anesthesia.METHOD: The were divided into four groups: Group C (n = 5) control group with no device used, L 5, LMA), P CobraPLA) V V-gel-rabbit).Basal values heart rate (HR), mean arterial pressure (MAP) ECG for interval measured measurements evaluated at 1, 15, 30 minutes after inserting RESULTS: HR, MAP 1 5 signifi cantly those (p <...

10.4149/bll_2015_122 article EN Bratislavské lekárske listy/Bratislava medical journal 2015-01-01

Abstract The authors have requested that this preprint be removed from Research Square.

10.21203/rs.3.rs-317015/v1 preprint EN cc-by Research Square (Research Square) 2021-03-19
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