A5080245088- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Ophthalmology and Eye Disorders
- Glaucoma and retinal disorders
- Ear Surgery and Otitis Media
- Cerebral Venous Sinus Thrombosis
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Advancements in PLL and VCO Technologies
- Olfactory and Sensory Function Studies
- Cardiovascular Syncope and Autonomic Disorders
- Neuroscience of respiration and sleep
- Spatial Cognition and Navigation
- Lipid metabolism and biosynthesis
- Visual perception and processing mechanisms
- Balance, Gait, and Falls Prevention
- Lipid metabolism and disorders
- Heart Rate Variability and Autonomic Control
- Motor Control and Adaptation
- Lipoproteins and Cardiovascular Health
- Ocular Surface and Contact Lens
- Sinusitis and nasal conditions
- Myofascial pain diagnosis and treatment
Nara Medical University
2015-2024
National Archives and Records Administration
2023
Tokyo Metropolitan Institute of Medical Science
2020-2021
Nara Medical University Hospital
2019-2020
Nippon Life Hospital
2014
Hitachi (Japan)
2006-2009
Niigata City General Hospital
2005
Otemae Hospital
1998
Hitachi Maxell (Japan)
1988
Conclusions: The incident ratios of cochlear and/or vestibular endolymphatic hydrops (EH) were significantly higher in the affected ears patients with Meniere's disease (MD) than healthy controls. There no significant differences between controls and contralateral MDs. Objectives: aim was to compare incidence EH unilateral/bilateral MD using 3T magnetic resonance imaging (MRI) intravenous gadolinium. Methods: A total 41 diagnosed MD: 32 unilateral (uMD) nine bilateral (bMD). Fifteen...
Meniere's disease is a common disease, with an incidence of 15-50 per 100,000, that presents recurrent vertigo and cochlear symptoms. The pathology was first reported to involve endolymphatic hydrops in 1938. sac thought maintain the hydrostatic pressure endolymph homeostasis for inner ear. As surgical treatment intractable drainage intraendolymphatic application large doses steroids performed control preserve or improve ear function. In present study, observe effect this surgery, we...
Meniere's disease, a common inner ear condition, has an incidence of 15-50 per 100,000. Because mental/physical stress and subsequent increase in the hormone vasopressin supposedly trigger we set pilot study to seek new therapeutic interventions, namely management secretion, treat this disease. We enrolled 297 definite patients from 2010 2012 randomized-controlled open-label trial, assigning Group-I (control) traditional oral medication, Group-II abundant water intake, Group-III tympanic...
Conclusion: This study described the lateralities of axial length inner ear (ALIE), volume (VIE) and age-related differences components in patients with chronic rhinosinusitis (CRS). Age-related were found ALIE positive correlation cochlea (VC) affected Meniere's disease (MD). Objective: To identify side or sex-related ALIE, spiral canal (LSCC), MD CRS.Methods: Thirty-two unilateral 14 CRS included. Images acquired a 3.0-tesla unit using SPACE sequences. The was measured VIE, VC, vestibule...
Recently, 3-Tesla magnetic resonance imaging (MRI) with intravenous gadolinium injection has been used to reveal endolymphatic hydrops (EH). In the present study, we aimed evaluate EH in patients Meniere's disease (MD) objectively and quantitatively, compared space (ELS) individuals MD healthy controls, gain understanding of characteristics MD.Eighty-two unilateral (uMD), 16 bilateral (bMD), 47 volunteers were enrolled. All participants underwent 3-T MRI at 4 hours after injection. The...
Conclusion: Magnetic resonance volumetric measurement of inner ear endolymphatic space (ELS) was performed in patients without vertiginous or cochlear symptoms. The existence the ELS with chronic rhinosinusitis (CRS) shown. cochlea and vestibule classified into four categories. These findings could be useful as a standard reference for further research.Objectives: To identify normal values vestibule.Methods: Twenty-four CRS were enrolled. Inner fluid images positive perilymph/positive...
Introduction: The present study aimed to determine whether supervised vestibular rehabilitation therapy (VRT) by physical therapists (PTs) affects subjective dizziness in patients with chronic disorders, and VRT-induced changes are related the activity levels daily life. Methods: Patients ( n = 47) peripheral disorders were randomly divided into VRT group 25) control 22). received weekly visits from PTs for a period of 6 months. Every other month, both groups advised neuro-otologists...
Background: The caloric test has been used to evaluate the semi-circular canal function for decades. In 2009, video head impulse (vHIT) was introduced, which can be within a short time. Although both tests examine canal, stimulation methods differ and it is unclear whether vHIT equivocal test.Aims/objectives: This study aimed discern differences between test.Material methods: comprised 112 patients with vertigo who visited vertigo/dizziness centre at our university hospital. Each of these...
Abstract The role of oligodendrocyte lineage cells, the largest glial population in adult central nervous system (CNS), pathogenesis Alzheimer’s disease (AD) remains elusive. Here, we developed a culture method for progenitor cells (aOPCs). Fibroblast growth factor 2 (FGF2) promotes survival and proliferation NG2 + aOPCs serum-free defined medium; subpopulation (~5%) plexin-B3 was also found. FGF2 withdrawal decreased , but increased Aβ1-42 secretion. Plexin-B3 were distributed throughout...
Background: Pathologically, Meniere's disease symptoms are considered to be associated with endolymphatic hydrops. Examinations revealing hydrops can useful for accurate diagnosis. We previously reported a quantitative method evaluating hydrops, i.e., by measuring the volume of space using three-dimensional magnetic resonance imaging (MRI) inner ear. This study aimed confirm usefulness our methods diagnosing disease. Here, we extracted new explanatory factors comparing between healthy...
The aim of the present study was to assess head-position management for intractable idiopathic benign paroxysmal positional vertigo (BPPV) when lying down. We hypothesized that head-up sleep (HUS) could prevent free-floating otoliths from entering semicircular canals.A prospective two-arm multicenter randomized controlled trial.BPPV diagnosed in 611 patients (611/1,520; 40.2%) according 2015 diagnostic guidelines issued by International Classification Vestibular Disorders. Among them, 201...
Conclusion: After repeated snowboard exercises in the virtual reality (VR) world with increasing time lags trials 3–8, it is suggested that adaptation to visual-vestibulosomatosensory conflict VR improved dynamic posture control and motor performance real without development of motion sickness.Objectives: The technology was used effects exercise examined between visual scene body rotation on head stability slalom run during healthy subjects.Methods: Forty-two young subjects participated...
Sensory conflicts leading to motion sickness can occur not only between but also within sensory modalities. The vestibular organs are located in both left and right inner ears, their misalignment be a source of self-motion related conflicts. In the current study, using ear magnetic resonance imaging, we examined whether morphological asymmetry bilateral was associated with susceptibility. results showed larger position individuals high rather than low addition, reciprocal interaction...
Susceptibility to motion sickness varies greatly across individuals. However, the neural mechanisms underlying this susceptibility remain largely unclear. To address gap, current study aimed identify correlates of using multimodal MRI. First, we compared resting-state functional connectivity between healthy individuals who were highly susceptible (N = 36) and age/sex-matched controls showed low 36). Seed-based analysis revealed between-group differences in core vestibular regions left...
Background: Endolymphatic sac drainage (ELSD) may have a positive effect on endolymphatic hydrops (EH) and help to preserve inner ear function. However, the relationship between changes in EH volumes hearing function after ELSD has not been described.Objectives: We aimed reveal factors related following ELSD.Material Methods: Twenty-one patients who received were enrolled. Pure tone audiometry 3-T magnetic resonance imaging (MRI) 4 h intravenous injection of gadolinium enhancement performed...
Background: Recently, 3-Tesla magnetic resonance imaging (MRI) after an intravenous gadolinium injection has been used to describe the endolymphatic space (ELS).Objectives: This study described histopathological differences between idiopathic sudden sensorineural hearing loss (ISSNHL) and fluctuating (FSNHL) by examining ELS. Additionally, relationship affected cochlear vestibular ELS/total fluid (TFS) volume ratio duration from onset MRI in patients with FSNHL were evaluated.Material...
When vestibular function is lost, compensation works for the reacquisition of body balance. For study dysfunction and compensation, surgical or chemical labyrinthectomy has been performed in various animal species. In present study, we using arsanilic acid mice investigated time course through behavioral observations histological studies. The procedures required only paracentesis storage 50 µL p-arsanilic sodium salt solution tympanic cavity 5 min. From observations, functions were worst at...
Meniere's disease is a common inner ear disorder accompanied by vertigo attacks and fluctuating hearing loss that some believe due to stressful lifestyle. To elucidate the scientific relationship in neuro-endocrinology between stress, we examined surgical results of endolymphatic sac drainage surgery changes stress-induced plasma arginine-vasopressin levels. We enrolled 100 intractable patients vasopressin Fifty-four chronic otitis media who underwent tympano-mastoidectomy formed control...