A5005642736- Tuberculosis Research and Epidemiology
- Air Quality and Health Impacts
- Energy and Environment Impacts
- Occupational and environmental lung diseases
- Antibiotics Pharmacokinetics and Efficacy
- Occupational Health and Safety Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Occupational exposure and asthma
- Infectious Diseases and Tuberculosis
- Healthcare Systems and Reforms
- Sarcoidosis and Beryllium Toxicity Research
- Antibiotic Resistance in Bacteria
- Air Quality Monitoring and Forecasting
- COVID-19 diagnosis using AI
- Global Maternal and Child Health
- Sepsis Diagnosis and Treatment
- COVID-19 Digital Contact Tracing
- Mycobacterium research and diagnosis
- Biomedical Text Mining and Ontologies
- Data-Driven Disease Surveillance
- bioluminescence and chemiluminescence research
- Antifungal resistance and susceptibility
- Bacterial Identification and Susceptibility Testing
- Pharmaceutical Practices and Patient Outcomes
- Economic, financial, and policy analysis
Kilimanjaro Christian Medical Centre
2021-2025
Nelson Mandela African Institution of Science and Technology
2024
Clinical Research Institute
2024
Addis Ababa University
2021-2023
Africa Center
2021
COVID-19 is one of the most deadly diseases to have stricken us in recent decades. In fight against this disease, governments and stakeholders require all assistance they can get from various systems, including digital health interventions. Digital technologies are supporting tracking outbreak, diagnosing patients, expediting process finding potential medicines vaccines, disinfecting environment, The establishment electronic medical records, computerized clinical decision support...
Introduction: Health Sector Development Plans (HSDPs) aim to accelerate movement towards achieving sustainable development goals for health, reducing inequalities, and ending poverty. Reproductive, maternal, newborn child health (RMNCH) services are vulnerable economic imbalances, including insecurity, unmet need healthcare, low expenditure. The same vulnerability influences the potential of a country combat global outbreaks such as COVID-19. We aimed provide some important insights into...
Air pollution is the second largest risk to health in Africa, and children with asthma are particularly susceptible its effects. Yet, there a scarcity of air exposure data from cities sub-Saharan Africa. We aimed identify potential reduction strategies for school living urban areas
Background The end tuberculosis (TB) strategy requires a novel patient treatment approach contrary to the one-size-fits-all model. It is well known that each patient’s physiology different and leads various rates of drug elimination. Therapeutic monitoring (TDM) offers way manage dosage adaptation but trained pharmacologists, which scarce in resource-limited settings. Objective We will develop an automated clinical decision support system (CDSS) help practitioners with rifampicin, one...
Introduction Sub-Saharan Africa shoulders the highest burden of global sepsis and associated mortality. In high HIV tuberculosis (TB) prevalent settings such as sub-Saharan Africa, TB is leading cause sepsis. However, anti-TB therapy often delayed may not achieve adequate blood concentrations in patients with Accordingly, this multisite randomised clinical trial aims to determine whether immediate and/or increased dose improves 28-day mortality for participants Tanzania or Uganda. Methods...
<h3>Background</h3> There are 44 million small-scale miners globally who face a significant burden of occupational lung disease. is need for expanded access to care and research, however clinical logistical challenges make the population difficult-to-access. better understand how research can be improved in this context. We aimed describe evaluate combined screening programme Mererani, an underground gemstone mining area Northern Tanzania. <h3>Methods</h3> Following mapping exercise identify...
<sec> <title>BACKGROUND</title> The end tuberculosis (TB) strategy requires a novel patient treatment approach contrary to the one-size-fits-all model. It is well known that each patient’s physiology different and leads various rates of drug elimination. Therapeutic monitoring (TDM) offers way manage dosage adaptation but trained pharmacologists, which scarce in resource-limited settings. </sec> <title>OBJECTIVE</title> We will develop an automated clinical decision support system (CDSS)...
Background: Suboptimal drug exposure in patients with drug-susceptible tuberculosis (DS-TB) can drive treatment failure. Pharmacodynamics (PD) biomarkers such as the plasma TB drug-activity (TDA) assay may guide dose finding studies and predict microbiological outcomes differently than conventional indices. Methods: A study was nested from phase 2b randomized double-blind controlled trial of Tanzanian who received a 600 mg, 900 or 1200 mg standard for DS-TB. Serum at 6 weeks collected over...
Background: Air pollution is the second largest health risk factor in Africa, with children asthma particularly susceptible to its effects. Yet, there a scarcity of air exposure data from cities Sub Saharan Africa (SSA).Methods: Personal particulate matter was monitored for 297 school 96h six SSA cities. Exposures were tagged into different microenvironments (school, commute and home) using GPS coordinates. Mixed effects models utilised identify most important determinants children’s...
Abstract Introduction The End Tuberculosis (TB) Strategy requires a novel patient treatment approach contrary to the “one-size fits all” model. It is well known that each patient’s physiology different and leads various rates of drug elimination. Therapeutic Drug Monitoring (TDM) offers way manage dosage adaptation but trained pharmacologists, which scarce in resource-limited settings. We, therefore, aim create an unprecedented Clinical Decision Support System (CDSS) will offer printable...
<b>Background:</b> Personal monitoring is now becoming popular both as a research tool and from health promotion perspective. We have previously reported the exposure profiles of children UK using MicroAethalometer (1). These results formed basis intervention studies to reduce pollution (2). sought explore differences in air two further countries where has date been limited. <b>Methods:</b> As part CAPPA pilot study we recruited aged 8-12 years (Tanzania South Africa). The MicroAeth was used...