A5041256719- Nicotinic Acetylcholine Receptors Study
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Traditional and Medicinal Uses of Annonaceae
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Receptor Mechanisms and Signaling
- Synthesis and Biological Evaluation
- Oxidative Organic Chemistry Reactions
- Sulfur-Based Synthesis Techniques
- Alkaloids: synthesis and pharmacology
- Fluorine in Organic Chemistry
- Sulfur Compounds in Biology
- Ion channel regulation and function
- Chemical synthesis and alkaloids
- Molecular Sensors and Ion Detection
- Cholinesterase and Neurodegenerative Diseases
- Synthetic Organic Chemistry Methods
- Natural product bioactivities and synthesis
- Supramolecular Chemistry and Complexes
- Photoreceptor and optogenetics research
- Chemical Synthesis and Reactions
- Pharmacological Receptor Mechanisms and Effects
- Free Radicals and Antioxidants
- Neuroscience and Neuropharmacology Research
Pontificia Universidad Católica de Chile
2015-2025
Thomas Jefferson University Hospital
2024
University of Hawaii Maui College
2022
University of Hawaiʻi at Mānoa
2022
Faculty (United Kingdom)
2015-2018
Universidad de Antioquia
2003-2017
Institut Català d'Investigació Química
2010-2016
District University of Bogotá
2014
Millennium Institute for Integrative Biology
2008-2012
Fraunhofer Chile Research Foundation
2011
Adding 2Ns: Palladium catalysis introduces two nitrogen groups in a new regio and chemoselective diamination of non-activated alkenes that proceeds under entirely intermolecular reaction control. This palladium-catalyzed employs commercial sources combination with hypervalent iodo(III) reagent as oxidant (see scheme; Tos=toluenesulfonyl). Detailed facts importance to specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They...
Palladium catalysis enables the regioselective difunctionalization of alkenes using saccharin as nitrogen source in initial step aminopalladation. Depending on reaction conditions, diamination or aminooxygenation pathways can be accessed hypervalent iodine reagents terminal oxidants. The allylic ethers originates from an unprecedented ambident behavior saccharin. participating palladium catalysts contain a palladium–saccharide unit. Two representative complexes this type could isolated and...
Styryl-functionalized nitroisoxazoles exhibit enhanced nonlinear optical properties and high thermal stability. Compound B7 shows promising red electroluminescence performance for potential use in OLED devices.
A simple supramolecular method for the direct self-assembly of comb-like complexes composed hydrocarbon polymers and perfluorocarbon mesogens is described. Halogen bonding highly directional, so that perfluoroalkyl residues with their rigid rod-like architecture result in materials a beautiful structure. The Figure shows an ORTEP view such co-crystals.
Nicotinic acetylcholine receptors are a family of ligand-gated nonselective cationic channels that participate in fundamental physiological processes at both the central and peripheral nervous system. The extent calcium entry through ion defines their distinct functions. α9α10 nicotinic cholinergic receptor, expressed cochlear hair cells, is peculiar member as it shows differences permeability across species. In particular, mammalian among which exhibit highest selectivity. This acquired...
A copper-catalyzed regio- and intermolecular aminofluorination of styrenes has been developed.
Palladium reicht zwei Stickstoffatome rein: Eine neuartige regio- und chemoselektive Diaminierung von nichtaktivierten Alkenen gelingt unter vollständiger intermolekularer Reaktionsführung. Diese Palladium-katalysierte Reaktion nutzt kommerzielle Stickstoffquellen in Kombination mit einem hypervalenten Iodreagens als Oxidationsmittel (siehe Schema; Tos=Toluol-4-sulfonyl). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents...
Abstract The mild and fast copper‐catalyzed radical regioselective aminoalkoxylation of styrenes by using N ‐fluorobenzenesulfonimide simple alcohols as nitrogen alkoxy sources, respectively, was investigated. aminoalkoxylated products obtained could be used in the synthesis new compounds with possible activity neurotransmitter receptor ligands.
Positive allosteric modulators (PAMs) facilitate endogenous neurotransmission and/or enhance the efficacy of agonists without directly acting on orthosteric binding sites. In this regard, selective α7 nicotinic acetylcholine receptor type II PAMs display antinociceptive activity in rodent chronic inflammatory and neuropathic pain models. This study investigates whether 3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2), a new putative α7-selective PAM, attenuates experimental pains mice.We tested...
A better comprehension on how different molecular components of the serotonergic system contribute to adequate regulation behaviors in animals is essential interpretation they are involved neuropsychiatric and pathological disorders. It possible study these "simpler" animal models including fly Drosophila melanogaster, given that most conserved between vertebrates invertebrates. Here we decided advance our understanding serotonin plasma membrane transporter (SERT) contributes...
A new triterpenoid (1) derived from 24-methylcycloartanol was isolated the leaves of Oxandra cf. xylopioides. An unusual structure compound assigned as 1, for which name berenjenol is proposed, on basis spectroscopic data natural product and its derivatives 2 3. The also afforded known monoterpene isoespintanol (4). Compounds 1 4 significantly reduced paw edema induced by carrageenan 64% 43%, at 3 h, respectively. Moreover, IL-1β production 72% 100 μM mRNA synthesis.
A series of aromatic Schiff bases, featuring 7-diethylamino-coumarin and with five different substituents at an adjacent phenyl ring, were synthesized characterized. With the aim assessing stability these dyes in acidic medium, their hydrolysis reactions kinetically studied absence presence macrocycle cucurbit[7]uril (CB[7]). Our results are consistent a model containing three forms substrates (un-, mono-, diprotonated) parallel reaction pathways. The pKa values rate constants estimated...
The chemical study of a dichloromethane extract from Azorella compacta was directed to the isolation characteristic mulinane and azorellane diterpenoids in order determine their gastroprotective activity.Usual chromatographic techniques on led 12 compounds, which were identified by spectroscopic properties. HCl/ethanol-induced gastric lesions model mice used activity.The new diterpenoids, 13β-hydroxymulinane (1), mulin-11,13-dien-20-ol (2), 13α-methoxyazorellanol (3)...
Duguevalline (1), a novel aporphinoid alkaloid, in addition to four known alkaloids, cleistopholine (2), O-methylmoschatoline (3), (-)-oliveroline (4) and (-)-oliveridine (5), were isolated characterized from Duguetia vallicola stems. Structural elucidation of these compounds was established by spectroscopic methods. Among them, alkaloids (2) exhibited antiplasmodial activity against Plasmodium falciparum. Keywords: isoquinoline duguetia vallicola, annonaceae,