A5077884023- Neurobiology and Insect Physiology Research
- Insect and Pesticide Research
- Insect and Arachnid Ecology and Behavior
- Circadian rhythm and melatonin
- Physiological and biochemical adaptations
- Insect Utilization and Effects
- Nicotinic Acetylcholine Receptors Study
- Plant and animal studies
- Sleep and Wakefulness Research
- Antioxidant Activity and Oxidative Stress
- Vector-borne infectious diseases
- Developmental Biology and Gene Regulation
- Plant Molecular Biology Research
- Animal Behavior and Reproduction
- Insect Resistance and Genetics
- Hormonal Regulation and Hypertension
- bioluminescence and chemiluminescence research
- Connexins and lens biology
- Olfactory and Sensory Function Studies
- Axon Guidance and Neuronal Signaling
- Study of Mite Species
- Genetics, Aging, and Longevity in Model Organisms
- Parkinson's Disease Mechanisms and Treatments
- Entomological Studies and Ecology
University of Puerto Rico at Río Piedras
2019-2024
University of Puerto Rico System
2022-2024
Pontificia Universidad Católica de Chile
2013-2020
In the mammalian olfactory bulb (OB), gap junctions coordinate synchronous activity among mitral and tufted cells to process information. insects, are also present in Antennal Lobe (AL), a structure homologous OB. The invertebrate junction protein ShakB contributes electrical synapses between AL Projections Neurons (PNs) Drosophila . Other proteins, including Innexin 7 (Inx7), expressed AL, but little is known about their contribution intercellular communication during information...
Biogenic amines (BAs) play a central role in the generation of complex behaviors vertebrates and invertebrates, including fly Drosophila melanogaster. The comparative advantages as genetic model to study contribution BAs stumble upon difficulty access brain ask relevant physiological questions. For instance, it is not known whether activation nicotinic acetylcholine receptors (nAChRs) induces release brain, phenomenon associated several vertebrates. Here, we describe new preparation efflux...
A better comprehension on how different molecular components of the serotonergic system contribute to adequate regulation behaviors in animals is essential interpretation they are involved neuropsychiatric and pathological disorders. It possible study these "simpler" animal models including fly Drosophila melanogaster, given that most conserved between vertebrates invertebrates. Here we decided advance our understanding serotonin plasma membrane transporter (SERT) contributes...
Recent studies have identified the Drosophila brain circuits involved in sleep/wake switch and pointed to modulation of neuronal excitability as one underlying mechanisms triggering sleep need. In this study we aimed explore link between homeostatic regulation behavior circadian circuit. For purpose, selected Pumilio (Pum), whose main function is repress protein translation has been linked during chronic patterns altered activity. Here effects Pum on homeostasis melanogaster, which shares...
Abstract Background Drosophila melanogaster lipophorin receptors (LpRs), LpR1 and LpR2, are members of the LDLR family known to mediate lipid uptake in a range organisms from humans. The vertebrate orthologs LpRs, ApoER2 VLDL-R, function as glycoprotein involved development central nervous system, Reelin, which is not present flies. VLDL-R associated with hippocampus cerebral cortex, important association areas mammalian brain, well neurodevelopmental neurodegenerative disorders linked those...
Abstract Alcohol exposure is known to trigger homeostatic adaptations in the brain that lead development of tolerance and dependence. These are also believed be root a series disturbances sleep patterns often manifest during alcoholism can have significant clinical economic consequences. Unfortunately, neuronal genetic pathways control effects alcohol on currently unknown, thus limiting our efforts find effective treatment. In this study, we conduct mechanistic exploration relationships...
ABSTRACT Reelin is a secreted glycoprotein with roles in the development of mammalian neocortex, hippocampus and cerebellum. This vertebrate signaling molecule also contributes to adult brain function. Mammalian increases complexity Drosophila Mushroom Body (MB) neurites, an effect mediated by LpR1 LpR2, orthologs receptors. Paradoxically, date, no ortholog has been described . Here, we report that protein product uncharacterized CG17739 gene, which named Drospondin, shares sequence homology...
Abstract Honey bee, Apis mellifera L. (Hymenoptera: Apidae), colonies and individuals respond variably to disturbances. The response depends on perception interpretation of stimuli requiring both neural modulation use energy. In this study, we examined the role brain metabolism in constitutive experience‐dependent differences defensive response. For differences, compared gene expression bees from gentle identified a standard colony‐level assay. changes defensiveness response, control that...
A highly challenging question in neuroscience is to understand how aminergic neural circuits contribute the planning and execution of behaviors, including generation olfactory memories. In this regard, electrophysiological techniques like Local Field Potential or imaging methods have been used answer questions relevant cell circuit physiology different animal models, such as fly Drosophila melanogaster. However, these do not provide information on neurochemical identity interest. Different...
Abstract Honey bee ( Apis mellifera sp.) colonies and individuals respond variably to disturbances. In this study, we examined the role of neural modulation metabolism in constitutive experience-dependent differences defensive response. We compared brain gene expression bees identified gentle a standard assay. For neuromodulation, membrane receptor genes for biogenic amines dopamine (DOPR2), octopamine (OAR), serotonin (5HT2a), enzyme synthesis pathway (THR). To examine metabolism, assessed...
Abstract Recent studies have identified the Drosophila brain circuits involved in sleep/wake switch and pointed to modulation of neuronal excitability as one underlying mechanisms triggering sleep need. In this study we aimed explore link between homeostatic regulation behavior circadian circuit. For purpose, selected homeostasis protein Pumilio (Pum), whose main function is repress translation has been linked during chronic patterns altered activity. Here effects Pum on melanogaster , which...