A5028004751- Neuroscience of respiration and sleep
- Nicotinic Acetylcholine Receptors Study
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Insect and Pesticide Research
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Neurobiology and Insect Physiology Research
- Heart Rate Variability and Autonomic Control
- Multiple Sclerosis Research Studies
- High Altitude and Hypoxia
- Neurogenesis and neuroplasticity mechanisms
- Obstructive Sleep Apnea Research
- Insect and Arachnid Ecology and Behavior
- RNA Interference and Gene Delivery
- Neurological Disorders and Treatments
- Plant and animal studies
- Adipose Tissue and Metabolism
- Cholinesterase and Neurodegenerative Diseases
- Infant Health and Development
- Olfactory and Sensory Function Studies
- Animal Behavior and Reproduction
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
Universidad Autónoma de Chile
2014-2024
Pontificia Universidad Católica de Chile
2000-2014
University of Oxford
2006-2007
University of Chile
1998-2002
The carotid body's physiological role is to sense arterial oxygen, CO 2 and pH. It however, also powerfully excited by inhibitors of oxidative phosphorylation. This latter observation the cornerstone mitochondrial hypothesis which proposes that oxygen sensed through changes in energy metabolism. All these stimuli act a similar manner, i.e. inhibiting background TASK‐like potassium channel (K B ) they induce membrane depolarization thus neurosecretion. In this study we have evaluated ATP...
Drosophila melanogaster has been successfully used as a simple model to study the cellular and molecular mechanisms underlying behaviors, including generation of motor programs. Thus, it shown that, in vertebrates, CNS biogenic amines (BA) serotonin (5HT) participate control Drosophila. Several evidence show that BA systems innervate an important association area insect brain previously associated planning and/or execution programs, Mushroom Bodies (MB). The main objective this work is...
Abstract Background Multiple sclerosis (MS) is an irreversible progressive CNS pathology characterized by the loss of myelin (i.e. demyelination). The lack followed a neurodegeneration triggering symptoms as diverse fatigue, motor, locomotor and sensory impairments and/or bladder, cardiac respiratory dysfunction. Even though there are more than fourteen approved treatments for reducing MS progression, still no cure disease. Thus, research very active field therefore we count with different...
Biogenic amines (BAs) play a central role in the generation of complex behaviors vertebrates and invertebrates, including fly Drosophila melanogaster. The comparative advantages as genetic model to study contribution BAs stumble upon difficulty access brain ask relevant physiological questions. For instance, it is not known whether activation nicotinic acetylcholine receptors (nAChRs) induces release brain, phenomenon associated several vertebrates. Here, we describe new preparation efflux...
A better comprehension on how different molecular components of the serotonergic system contribute to adequate regulation behaviors in animals is essential interpretation they are involved neuropsychiatric and pathological disorders. It possible study these "simpler" animal models including fly Drosophila melanogaster, given that most conserved between vertebrates invertebrates. Here we decided advance our understanding serotonin plasma membrane transporter (SERT) contributes...
Multiple sclerosis (MS) is a chronic and degenerative disease that impacts central nervous system (CNS) function. One of the major characteristics presence regions lacking myelin an oxidative inflammatory environment. TGF-β1 Nrf2 proteins play fundamental role in different oxidative/inflammatory processes linked to neurodegenerative diseases such as MS. The evidence from experimental settings has demonstrated TGF-β1-Nrf2 signaling crosstalk under pathological conditions. However, this...