Paula Lombide

ORCID: 0000-0002-3777-7708
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About
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Research Areas
  • Reproductive Biology and Fertility
  • Hypothalamic control of reproductive hormones
  • Bee Products Chemical Analysis
  • Neuroendocrine regulation and behavior
  • Estrogen and related hormone effects
  • Birth, Development, and Health
  • Rabbits: Nutrition, Reproduction, Health
  • Sperm and Testicular Function
  • Ovarian function and disorders
  • Sexual Differentiation and Disorders
  • Ovarian cancer diagnosis and treatment
  • Healthcare and Venom Research
  • Reproductive Physiology in Livestock
  • Renal and related cancers
  • Insect and Pesticide Research
  • Neuropeptides and Animal Physiology
  • Testicular diseases and treatments
  • Heat shock proteins research
  • Veterinary Equine Medical Research
  • Pregnancy-related medical research
  • Growth Hormone and Insulin-like Growth Factors
  • Medicinal Plant Pharmacodynamics Research
  • Cardiovascular, Neuropeptides, and Oxidative Stress Research
  • Reproductive System and Pregnancy
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients

Universidad de la República
2000-2021

Universidad de Montevideo
2007

Centro Uruguayo de Imagenología Molecular
2002-2006

The present study analyses the participation of ovarian innervation during reproductive senescence. We use model acute peripheral pharmacological sympathetic denervation with guanethidine in young (3 months old), middle-aged (12 old) or old (18 rats spontaneous induced ovulation. Ovarian levels norepinephrine (NE) were measured by HPLC and oestrous cycle, number ovulating animals percentage atretic follicles also assessed. Aged showed a progressive reduction ovulatory capacity an increase NE...

10.1071/rd07075 article EN Reproduction Fertility and Development 2007-01-01

In mammals, pregnancy induces a transient and extensive degeneration of uterine sympathetic innervation. We used the models unilateral oviduct ligation in oculo myometrium transplant pregnant rats to address role stretching forces and/or hormone milieu loss The fibres horn myometrial transplants were quantified on tissue sections processed by glyoxylic acid technique. normal rats, density innervation was significantly reduced at late recovery took place during post partum. empty showed no...

10.1071/rd05053 article EN Reproduction Fertility and Development 2006-01-01

Abstract Maternal undernutrition decreases sperm production in male offspring, possibly through insulin-like growth factor (IGF-I). To test this hypothesis, we fed pregnant Wistar rats ad libitum with a standard diet (CONTROL) or 50% of CONTROL intake, either throughout pregnancy (UNP), lactation (UNL, both (UNPL). After weaning, offspring ( n = 10 per treatment) were until postnatal day 160, when testes process for histological and molecular analyses. IGF-I immunostaining area intensity the...

10.1017/s2040174420000306 article EN Journal of Developmental Origins of Health and Disease 2020-04-28

Prenatal glucocorticoids, commonly used in women at risk of preterm delivery, can predispose the newborn to disease later life. Since male reproductive function is likely reflect testis development during fetal life, we studied effects prenatal glucocorticoids on two key intra-testicular factors that play roles cellular proliferation and differentiation, 3β-hydroxysteroid dehydrogenase (3β-HSD) inhibin-α. Pregnant sheep ( n =42) were treated with betamethasone (0.5 mg/kg) or saline (control)...

10.1017/s2040174416000118 article EN Journal of Developmental Origins of Health and Disease 2016-03-29

We tested whether changes in Sertoli cell transcription factors and germ heat shock proteins (HSPs) are linked to the effects of maternal undernutrition on male offspring fertility. Rats were fed ad libitum with a standard diet (CONTROL) throughout pregnancy lactation or 50% CONTROL intake (UNP) (UNL) both periods (UNPL). After postnatal Day 21, 10 pups per group until 160 when testes processed for histological, mRNA immunohistochemical analyses. Compared CONTROL: caspase-3 was increased UNP...

10.1071/rd20260 article EN cc-by-nc-nd Reproduction Fertility and Development 2021-04-22

Heat shock proteins play a crucial role in cellular development, proliferation, differentiation and apoptosis. protein 90 (HSP90) has been localised the human endometrium, where its immunoexpression changes during menstrual cycle. Similar studies have not done for equid species, so present study aimed to describe endometrial HSP90 mare endometrium. Endometrial biopsies were formalin-fixed paraffin-embedded, sections stained with haematoxylin-eosin preparation immunohistochemistry....

10.1111/ahe.12598 article EN Anatomia Histologia Embryologia 2020-08-10

RESUMEN: La vitrificación de ovocitos mamíferos es considerada una técnica en experimentación.La supervivencia los extremadamente variable, según las técnicas utilizadas e influida por serie condiciones.El objetivo éste trabajo fue determinar efectos la gata domestica adulta estación reproductiva y madurados in vitro.Se obtuvieron 33 ovarios correspondientes a hembras más un año buen estado nutricional sin tratamiento hormonal, ovariectomizadas domicilio del propietario profesional...

10.4067/s0717-95022015000400008 article ES International Journal of Morphology 2015-12-01

RESUMEN: La criopreservación de semen es una importante biotecnología reproductiva que viene siendo utilizada con éxito desde hace casi 50 años busca promover la conservación del germoplasma masculino.Si bien en actualidad se han desarrollado sistemas electrónicos automatizados portátiles, muchos técnicos continúan utilizando el método convencional congelación por su practicidad, bajo costo y buena eficiencia.En este trabajo, protocolos estandarizados para evaluación machos otras especies...

10.4067/s0717-95022016000100039 article ES International Journal of Morphology 2016-03-01

Abstract Toxic honeydew produced by Flatidae Epormenis cestri in Uruguay has been shown to cause among honeybees ( Apis mellifera ) colonies a massive larva death called “River disease”, but the intrinsic mechanisms are still unknown. Because fat body cells, oenocytes and trophocytes, known regulated larvae metabolism, be affected xenobiotics, we tested whether apoptosis of these cells can an underlying death. Ten were divided into two groups fed with common honey or toxic obtained from...

10.2478/jas-2021-0006 article EN cc-by Journal of Apicultural Science 2021-04-26
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