A5087865591- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Bacterial Infections and Vaccines
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
- Tracheal and airway disorders
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal and Maternal Infections
- Gastroesophageal reflux and treatments
- Cystic Fibrosis Research Advances
- Congenital Diaphragmatic Hernia Studies
- Pharmaceutical studies and practices
- Urinary Bladder and Prostate Research
- Delphi Technique in Research
- Sepsis Diagnosis and Treatment
- Allergic Rhinitis and Sensitization
- Obstructive Sleep Apnea Research
- Child and Adolescent Health
- Eosinophilic Esophagitis
- Health disparities and outcomes
- Streptococcal Infections and Treatments
Virginia Commonwealth University
2023-2025
University Health System
2023-2025
Queen's University Belfast
2015-2024
Royal Belfast Hospital for Sick Children
2015-2024
Johns Hopkins University
2024
Respiratory Clinical Trials
2024
Texas A&M University
2023
Belfast Health and Social Care Trust
2012-2022
Universidad del Noreste
2022
Uniwersytet SWPS
2022
There are a lack of reliable data on the epidemiology and associated burden costs asthma. We sought to provide first UK-wide estimates epidemiology, healthcare utilisation asthma.We obtained analysed asthma-relevant from 27 datasets: these comprised national health surveys for 2010-11, routine administrative, social care datasets 2011-12; 2011-12 were estimated in pounds sterling using economic modelling.The prevalence asthma depended definition source used. The UK lifetime patient-reported...
Summary Background It seems plausible that children with atopy and persistent asthma symptoms will, like their adult counterparts, have chronic airways inflammation. However, many young no other atopic features episodic wheezing is triggered solely by viral respiratory infections. Little known as to whether inflammation occurs in these two patterns during relatively asymptomatic periods. Methods Using a non‐bronchoscopic bronchoalveolar lavage (BAL) procedure on presenting for an elective...
Step 1 MDS performed a database literature search (Medline, Embase, Cochrane Library and Google Scholar) initially using the terms ''cough'' AND ''child''.Exclusions included non-English language papers on pertussis vaccine development.Also excluded were specific diseases including asthma, cystic fibrosis pneumonia for which management guidelines have already been published.Abstracts of then reviewed relevant obtained.The studies to UK population largely in Europe, North America, Australia,...
Respiratory syncytial virus (RSV) is the major viral cause of severe pulmonary disease in young infants worldwide. However, mechanisms by which RSV causes humans remain poorly understood. To help bridge this gap, we developed an ex vivo/in vitro model infection based on well-differentiated primary pediatric bronchial epithelial cells (WD-PBECs), targets vivo. Our RSV/WD-PBEC demonstrated remarkable similarities to hallmarks infant lungs. These included restriction noncontiguous or small...
As more preterm infants recover from severe bronchopulmonary dysplasia (BPD), it is critical to understand the clinical consequences of this condition on lung health adult survivors.To assess structural and functional parameters in young BPD survivors term control subjects.Young (mean age, 24 yr) underwent spirometry, volume assessment, transfer factor, clearance index, fractional exhaled nitric oxide measurements, together with high-resolution chest computed tomography cardiopulmonary...
Rationale: Respiratory syncytial virus (RSV) is a major pathogen that primarily infects airway epithelium. Most infants suffer mild upper respiratory tract (URT) symptoms, whereas approximately one-third progress to lower (LRT) involvement. Despite the ubiquity of URT infection, little known about relative cytopathogenesis RSV infection in infant and LRT.Objectives: This study aimed compare nasal- bronchial-derived epithelium from same individuals using novel models derived...
Adherence to treatment is often reported be low in children with cystic fibrosis. fibrosis an important research area and more needed better understand family barriers adherence order for clinicians provide appropriate intervention. The aim of this study was evaluate enzyme supplements, vitamins chest physiotherapy determine if any modifiable risk factors are associated adherence. A sample 100 (≤18 years) (44 male; median [range] 10.1 [0.2-18.6] their parents were recruited the from Northern...
Respiratory syncytial virus (RSV) is the major cause of viral lower respiratory tract illness in children. In contrast to RSV prototypic strain A2, clinical isolate 2-20 induces airway mucin expression mice, a clinically relevant phenotype dependent on fusion (F) protein strain. Epidermal growth factor receptor (EGFR) plays role other systems; therefore, we hypothesized that F stimulates EGFR signaling. Infection cells with chimeric strains A2-2-20F and A2-2-20GF or over-expression resulted...
Abstract Background Human respiratory syncytial virus (RSV) causes severe disease in infants. Airway epithelial cells are the principle targets of RSV infection. However, mechanisms by which it poorly understood. Most pathogenesis data derived using laboratory-adapted prototypic strains. We hypothesized that such strains may be representative recent clinical isolates terms virus/host interactions primary human bronchial (PBECs). Methods To address this hypothesis, we isolated three from...
ABSTRACT Airway epithelium is the primary target of many respiratory viruses. However, virus induction and antagonism host responses by human airway remains poorly understood. To address this, we developed a model syncytial (RSV) infection based on well-differentiated pediatric bronchial epithelial cell cultures (WD-PBECs) that mimics hallmarks RSV disease in infants. most important viral pathogen young infants worldwide. We found induces potent antiviral state WD-PBECs was mediated part...
Objectives (1) Systematically assemble, analyse and synthesise published evidence on causes of prescribing error in children. (2) Present results to a multidisciplinary group paediatric stakeholders validate findings establish how causative factors lead errors practice. Design Scoping review using Arksey O’Malley’s framework, including stakeholder consultation; qualitative synthesis. Methods We followed the six scoping stages. Research question—the research question was ‘What is known about...
There is increasing evidence that the airway microbiome plays a key role in establishment of respiratory health by interacting with developing immune system early life. While it has become clear bacteria are involved this process, there knowledge gap concerning fungi. Moreover, inter-kingdom interactions influence development remain unknown. In prospective exploratory human study, we aimed to determine post-natal microbial and immunological features upper airways 121 healthy newborns.
ABSTRACT Introduction and Objective Observable autonomous rhythmic changes in intravesical pressure, termed bladder wall micromotion , is a phenomenon that has been linked to urinary urgency, the key symptom overactive (OAB). However, mechanism through which drives urgency poorly understood. In addition, inherently difficult study human urodynamics due challenges distinguishing it from normal cyclic physiologic processes such as pulse rate, breathing, rectal contractions, ureteral jetting....
The aim of this study was to investigate the influence genetic polymorphisms in ABCB1 on incidence nephrotoxicity and tacrolimus dosage-requirements paediatric patients following liver transplantation.Fifty-one transplant recipients receiving were genotyped for C1236>T, G2677>T C3435>T polymorphisms. Dose-adjusted trough concentrations estimated glomerular filtration rates (EGFR) indicative renal toxicity determined correlated with corresponding genotypes.The present revealed a higher...
We examine the effect of survey measurement error on empirical relationship between child mental health and personal family characteristics, educational progress. Our contribution is to use unique UK data that contain (potentially biased) assessments each child's state from three observers (parent, teacher child), together with expert (quasi-)diagnoses, using an assumption optimal diagnostic behaviour adjust for reporting bias. alternative restrictions identify disorders Maternal education...