A5091888628- Cardiovascular Health and Risk Factors
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Diet and metabolism studies
- Birth, Development, and Health
- Topic Modeling
- Glaucoma and retinal disorders
- Anesthesia and Sedative Agents
- Diet, Metabolism, and Disease
- Machine Learning in Healthcare
- Liver Disease Diagnosis and Treatment
- Sympathectomy and Hyperhidrosis Treatments
- Optical Imaging and Spectroscopy Techniques
- Intensive Care Unit Cognitive Disorders
- Cardiovascular Disease and Adiposity
- Artificial Intelligence in Healthcare and Education
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Dental Anxiety and Anesthesia Techniques
- Obstructive Sleep Apnea Research
- Epigenetics and DNA Methylation
- EEG and Brain-Computer Interfaces
- Stroke Rehabilitation and Recovery
- Cardiovascular and exercise physiology
- Medical Imaging and Analysis
- Migraine and Headache Studies
Boston University
2020-2025
University School
2020-2024
Boston Medical Center
2020-2022
Brigham and Women's Hospital
2021-2022
Mass General Brigham
2022
Accurate, automated extraction of clinical stroke information from unstructured text has several important applications. ICD-9/10 codes can misclassify ischemic events and do not distinguish acuity or location. Expeditious, accurate data could provide considerable improvement in identifying large datasets, triaging critical reports, quality efforts. In this study, we developed report a comprehensive framework studying the performance simple complex stroke-specific Natural Language Processing...
Background The association of the American Heart Association's updated cardiovascular health score, Life's Essential 8 (LE8), with disease (CVD) and death is not described in FHS (Framingham Study). Methods Results We evaluated Framingham Offspring participants at examinations 2 6 (n=2888 1667; mean age, 44 57 years, respectively), free CVD information on LE8 components. Using age‐sex–adjusted Cox models, we related its change (examination to examination 6) risk compared associations those...
Life's Essential 8 (LE8) is an enhanced metric for cardiovascular health. The interrelations among LE8, biomarkers of aging, and disease risks are unclear.
Clinical interpretation of continuous glucose monitoring (CGM) data for people without diabetes has not been well established. This study aimed to investigate concordance among CGM experts in recommending clinical follow-up individuals diabetes, based upon their independent review data. We sent a survey out expert clinicians (n = 18) and asked them evaluate 20 potentially challenging Dexcom G6 Pro reports (and hemoglobin A1c [HbA1c] fasting venous blood levels) from diabetes. Clinicians...
To describe the prevalence and associated risk factors of new onset anisocoria (new pupil size difference at least 1 mm) its subtypes: accompanied by abnormal normal reactivities in patients with acute neurologic injuries.We tested association who experienced subtypes degree midline shift using linear regression. We further explored differences between quantitative characteristics first-time nonnew preceding observations mixed effects logistic regression, adjusting for possible...
OBJECTIVES: In critically ill patients with neurologic disease, pupil examination abnormalities can signify evolving intracranial pathology. Analgesic and sedative medications (analgosedatives) target pupillary pathways, but it remains unknown how analgosedatives alter findings in the clinical care setting. We assessed dexmedetomidine other analgosedative associations reactivity size a heterogeneous cohort of acute DESIGN: Retrospective study. SETTING: Two ICUs between 2016 2018. PATIENTS:...
The relation of cardiorespiratory fitness (CRF) to lifestyle behaviors and factors linked with cardiovascular health remains unclear. We aimed understand how the American Heart Association's Life's Essential 8 (LE8) score (and its changes over time) relate CRF complementary exercise measures in community-dwelling adults.
Background Asymmetric pupil reactivity or size can be early clinical indicators of midbrain compression due to supratentorial ischemic stroke primary intraparenchymal hemorrhage (IPH). Radiographic midline shift is associated with worse functional outcomes and life-saving interventions. Better understanding quantitative characteristics would a non–invasive, safe, cost-effective way improve identification life-threatening mass effect resource utilization emergent radiographic imaging. We...
Eye movement quantification in polysomnograms (PSG) is difficult and resource intensive. Automated eye detection would enable further study of patterns normal abnormal sleep, which could be clinically diagnostic neurologic disorders, or used to monitor potential treatments. We trained a long short-term memory (LSTM) algorithm that can identify occurrence with high sensitivity specificity. conducted retrospective, single-center using one-hour PSG samples from 47 patients 18-90 years age. Team...
Background: There is limited understanding of the association AHA's Life's Essential 8 (LE8), reflecting cardiovascular health (CVH) behaviors and factors, with vascular stiffness hemodynamics in adults without diseases (CVD). Methods: In 2330 Framingham Heart Study Offspring participants (Exam 7, 1998-2002) applanation tonometry LE8 data (diet, physical activity, smoking, sleep health, BMI, lipids, glucose, blood pressure), we calculated CVH scores per AHA guidelines. multivariable linear...
Arterial stiffening may contribute to the pathogenesis of metabolic dysfunction-associated steatotic liver disease. We aimed assess relations vascular hemodynamic measures with hepatic steatosis and fibrosis in community.
Background: Higher arterial stiffness contributes to atherogenesis and calcification, resulting in cardiovascular morbidity mortality. Research Question: The relations of lifestyle, measured by the AHA Life’s Essential 8 (LE8), with health (AH) CVD outcomes are incompletely understood. Aims: To examine association LE8 AH extent which carotid-femoral pulse wave velocity (PWV) mediates a sample free CVD. Methods: In 3 Framingham Heart Study cohorts, we studied (total score components) AH,...
The association of overall cardiovascular health (CVH) with changes in DNA methylation (DNAm) has not been well characterized.
Introduction: Many studies have reported that obesity-related metabolic abnormalities (such as diabetes and hypertension) lead to myocardial dysfunction adverse cardiac remodeling. However, it is challenging disentangle the effects of obesity from those its associated comorbidities. Comparing metabolically healthy adults across different body mass index (BMI) categories can help delineate independent effect on remodeling impact Hypothesis: We hypothesized overweight (MHOW) obese (MHO)...
Objective: To describe the incidence of clinical anisocoria and its relationship with poor-pupil reactivity in a heterogenous Neuro-ICU population. Background: Anisocoria is an asymmetry pupil size classically considered significant when difference at least 1mm. has multiple etiologies, including intracranial compression pupillary pathways. In certain contexts, prompts emergent diagnostic workup and/or treatment. Its association poor Neurocritical-Care patients remains poorly described....
To test the effect of dexmedetomidine on pupil reactivity and size in a heterogenous cohort critically ill patients with neurologic emergencies.
To evaluate quantified eye movement frequency using electrooculography (EOG) in comatose cardiac arrest patients compared to sleep study controls.