A5101856683- Cardiac electrophysiology and arrhythmias
- Drug Transport and Resistance Mechanisms
- Cardiac Arrest and Resuscitation
- Cancer, Lipids, and Metabolism
- Inflammation biomarkers and pathways
- Connexins and lens biology
- Cancer-related molecular mechanisms research
- Cardiac Arrhythmias and Treatments
- Anesthesia and Sedative Agents
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Hypoxia, and Metabolism
- Regulation of Appetite and Obesity
- ATP Synthase and ATPases Research
- Cardiac Ischemia and Reperfusion
- Cardiovascular Health and Risk Factors
- Anesthesia and Pain Management
- Anesthesia and Neurotoxicity Research
- S100 Proteins and Annexins
- Asthma and respiratory diseases
- Infectious Diseases and Mycology
- Cancer Research and Treatments
- Healthcare Decision-Making and Restraints
- 14-3-3 protein interactions
- Cytokine Signaling Pathways and Interactions
- Fungal Infections and Studies
Wuhan University
2012-2024
Renmin Hospital of Wuhan University
2011-2024
To investigate and compare the effects of propofol midazolam on inflammation oxidase stress in children with congenital heart disease undergoing cardiac surgery.Thirty-two ASA class I-II surgery were randomly divided into two groups: combined low dose fentanyl (PF group, n = 16) (MF 16). Tracheal extubation time length Intensive Care Unit (ICU) stay recorded. Blood samples taken before operation (T₀), at 2 h after release aorta cross-clamp (T₃) 24 (T₄) to measure interleukin 6 (IL-6), IL-8,...
Abstract LncRNAs play crucial roles in the development of various cancers including hepatocellular carcinoma (HCC). Nevertheless, function long noncoding RNA (lncRNA) FOXD2‐AS1 HCC is still poorly understood. In this study, we focused on role HCC. We found that was significantly upregulated cells comparison to normal human liver cells, LO2. also demonstrated miR‐206 expression greatly reduced cells. Furthermore, inhibition repressed cell proliferation, enhanced apoptosis, and restrained...
Abstract Objective This study compared remimazolam tosylate with propofol or midazolam to assess its safety and effectiveness for long-term sedation of intensive care unit (ICU) patients requiring mechanical ventilation. Methods Adult in the ICU receiving ventilation longer than 24 h were included this single-center, prospective, observational study. Depending on sedatives they given, split into two groups (midazolam group; group). mortality was main result. Laboratory tests, adverse events,...
Sepsis-induced cardiomyopathy (SIC) is characterized by high mortality and poor outcomes. This study aimed to explore the relationship between testosterone soluble ST2 (sST2) all-cause in patients with SIC. Clinical data from SIC at Renmin Hospital of Wuhan University January 2021 March 2023 were reviewed. Serum sST2 measured admission. Kaplan–Meier analysis receiver operative characteristic curve (ROC) used estimate predictive values on 28 days 90 A total 327 male subjects enrolled this...
Background Talaromycosis is a serious opportunistic infectious disease caused by Talaromyces marneffei , which mostly occurs in immunocompromised patients. The mainly prevalent tropical countries and regions of Southeast Asia South Asia, but non-endemic areas also have patients with Talaromycosis. has no characteristic clinical manifestations difficult to diagnose. Delayed diagnosis often leads death. Case presentation Both had cellular immunodeficiency. 1 history acquired immune deficiency...
Rotigaptide is a new anti-arrhythmic peptide, which has recently been found to increase junctional conductance and prevent ischemia-induced ventricular tachycardia. In this study, we attempted investigate the effects mechanisms of rotigaptide on vulnerability arrhythmias in rabbits with heart failure (HF).
The mechanisms underlying focal atrial tachycardia (AT) are unclear.In 14 pentobarbital anesthetized dogs, a right thoracotomy allowed electrical stimulation (ES) of the anterior ganglionated plexi (ARGP). After ES was applied to ARGP at baseline, atropine, 1 mg/cc, injected into and repeat applied. left (n = 8), similar procedure followed by atropine superior (SL) GP.ES (0.6-3.2 V) SLGP caused an average reduction in sinus rate from 151 ± 14/min 60 11/min. At ≥4.5 V fibrillation (AF)...
Objective To investigate the protective effect of multidrug resistant associated protein 4 (MRP4) inhibitor on rats with sepsis-induced acute lung injury (ALI). Methods Sixty Sprague-Dawley (SD) were randomly divided into sham group, sepsis group and MRP4 MK571 treatment 20 in each group. Sepsis model was reproduced by cecal ligation puncture operation (CLP), only received celiotomy without puncture. Rats intraperitoneally injected (20 mg/kg) 30 minutes before reproduction, while...
Objective. To determine the effect and mechanism of anti-inflammatory agent ghrelin on pulmonary vascular dysfunction (PVD) in lipopolysaccharide- (LPS-) induced acute lung injury (ALI) rat models. Methods. Thirty-two adult male Sprague Dawley rats (n = 16/group) were randomly divided into saline groups, wherein (10 nmol/kg) or was subcutaneously administered. After 30 min, eight from each group selected, LPS (5 mg/kg) administered by intratracheal instillation to induce ALI. Four hours...
Objective To explore the effects of multidrug resistance-associated protein 4 (MRP4) inhibition on pulmonary vascular endothelial barrier dysfunction in septic rats. Methods Sixty Sprague Dawley rats were randomly (random number) divided into three groups: sham-operated group, sepsis and plus MRP4 inhibitor treatment with 20 each group. Sepsis was induced by cecal ligation puncture. MK571 (20 mg/kg) administrated intraperitoneal injection 30 minutes before induction sepsis....
Objective To compare the myocardial damage in patients with severe valvular heart disease undergoing open surgery under propofol and sevoflurane combined anesthesia.Methods Thirty-two were randomized into 3 groups:midazolam group (group M,n =8),propofol P,n =12) S,n =12).Midazolam 1-5 mg,vecuronium 0.15 mg/kg fentanyl 10-20 μg/kg injected intravenously M.Propofol 1-2 mg/kg,vecuronium 10 P.In S,the inhaled until eyelash reflex disappeared,the end-tidal concentration of was 0.5 ％-2.0％,and...
To investigate the effect of multidrug resistance protein 4 (MRP4) overexpression on lipopolysaccharide (LPS)-induced vascular endothelial hyperpermeability rat pulmonary micro-vascular cells (PMVECs) and its molecule mechanism.Three to six passages PMVECs were cultured in vitro, they divided into three groups: LPS group only challenged by 10 μg/mL after being serum-free medium for 24 hours; Ad-shRNA Ad-MRP4 groups infected with empty virus control or recombinant adenovirus expressing MRP4 2...
Objective To investigate the effects of multidrug resistance-associated protein 4 (MRP4) on cytoskeleton and cellular permeability rat pulmonary microvascular endothelial cells (PMVECs) induced by lipopolysaccharide (LPS). Methods PMVECs were cultured for 3 to 6 generations randomly divided into groups: control group, LPS Ad-shMRP4 group(adenoviral expression a short-hairpin RNA directed against MRP4), Ad-shRNA group. The infection rate was detected fluorescence microscope...
To investigate influences of estrogen-related receptor α(ERRα) on pulmonary vascular endothelium rats undergoing sepsis.Male Sprague-Dawley (SD) were divided into four groups according to the random number table method (12 in each group): normal control group (NC group), sham operation (Sham sepsis model caused by cecal ligation and puncture (CLP) (CLP XCT790 intervention (XCT790 group, given 2.5 mg/kg via intraperitoneal injection 30 minutes before CLP). After 24 hours, sacrificed organs...
Objective To investigate the effect of estrogen-related receptor alpha(ERRα)on lipopolysaccharide-induced inflammatory response in rat pulmonary microvascular endothelial cells (PMVECs) and its mechanism. Methods PMVECs were cultured vitro. When logarithmic growth phase, cell ransfected with lentivirus, a stable low-expression ERRα line was constructed. The divided into four groups: Ctr group (normal control group), Ctr+LPS cell+LPS treatment shERRα1 (shERRα1 gene knockdown...