A5002416893- Cardiac and Coronary Surgery Techniques
- Sepsis Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Biochemical effects in animals
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer-related molecular mechanisms research
- COVID-19 and healthcare impacts
- Machine Learning in Healthcare
- COVID-19 diagnosis using AI
- Neuroinflammation and Neurodegeneration Mechanisms
- Vagus Nerve Stimulation Research
- IL-33, ST2, and ILC Pathways
- Acute Kidney Injury Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Circular RNAs in diseases
- Anesthesia and Pain Management
- Asthma and respiratory diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Drug Transport and Resistance Mechanisms
- Traditional Chinese Medicine Studies
- Inflammation biomarkers and pathways
Wuhan University
2007-2025
Renmin Hospital of Wuhan University
2007-2025
To investigate and compare the effects of propofol midazolam on inflammation oxidase stress in children with congenital heart disease undergoing cardiac surgery.Thirty-two ASA class I-II surgery were randomly divided into two groups: combined low dose fentanyl (PF group, n = 16) (MF 16). Tracheal extubation time length Intensive Care Unit (ICU) stay recorded. Blood samples taken before operation (T₀), at 2 h after release aorta cross-clamp (T₃) 24 (T₄) to measure interleukin 6 (IL-6), IL-8,...
Sepsis-induced cardiomyopathy (SIC) is characterized by high mortality and poor outcomes. This study aimed to explore the relationship between testosterone soluble ST2 (sST2) all-cause in patients with SIC. Clinical data from SIC at Renmin Hospital of Wuhan University January 2021 March 2023 were reviewed. Serum sST2 measured admission. Kaplan–Meier analysis receiver operative characteristic curve (ROC) used estimate predictive values on 28 days 90 A total 327 male subjects enrolled this...
The heterogeneity nature of sepsis is significantly impacted by the site infection. This study aims to explore predictive value multiple scoring systems in assessing prognosis septic patients across different infection sites. Data for this retrospective cohort were extracted from Medical Information Mart Intensive Care IV database (MIMIC-IV) (v2.2). Adult meeting criteria 3.0 and admitted intensive care unit (ICU) enrolled. Infection sites included pneumonia, urinary tract (UTI), cellulitis,...
Sepsis-induced myocardial dysfunction (SIMD) is the most common complications of sepsis and septic shock with extremely high incidence mortality. Lipocalin 10 (Lcn10) has recently been identified as a potential biomarker for heart failure, yet its relation to not investigated. The purpose this study was explore whether circulating Lcn10 could be used prognostic tool in patients SIMD.In single-center observational pilot study, seventy-five were enrolled after diagnosis or ICU admission (45.3%...
Background: Wuhan, the capital city of Hubei Province, is epicenter COVID-19 breakout started in December 2019[1, 2]. Health administration department are looking for accurate grading system that can predict severity disease and thus provide guidance on effectively management treatment options patients.Methods: In this retrospective, single-center study, a total 669 pneumonia patients confirmed between 2 January 2020 to 10 February were included statistical analyses modeling. Real-time...
The infectious coronavirus disease 2019 (COVID-19) has spread all over the world and been persistently evolving so far. number of deaths in whole rising rapidly. However, early warning factors for mortality have not well ascertained. In this retrospective, single-centre cohort study, we included some adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Renmin Hospital Wuhan University who had discharged or died by Apr. 8, 2020. Demographic, clinical laboratory data at...
Objective To investigate the effects of galantamine treatment on intestinal function in rats with sepsis.Methods Healthy male Sprague-Dawley(SD) were randomly divided into five experimental groups:Sham CLP group:rats exposure abdominal cavity only.CLP group:cecal ligation and puncture (CLP) method to establish sepsis model.CLP+galantamine group:adminisration (5 mg/kg.ip) 1 h after CLP.vagotomy+CLP+galantamine group;right vagotomy 3 d before CLP.Sham vagotomy+CLP+galantamine group:Sham right...
Objective To explore the effects of multidrug resistance-associated protein 4 (MRP4) inhibition on pulmonary vascular endothelial barrier dysfunction in septic rats. Methods Sixty Sprague Dawley rats were randomly (random number) divided into three groups: sham-operated group, sepsis and plus MRP4 inhibitor treatment with 20 each group. Sepsis was induced by cecal ligation puncture. MK571 (20 mg/kg) administrated intraperitoneal injection 30 minutes before induction sepsis....
Objective To compare the myocardial damage in patients with severe valvular heart disease undergoing open surgery under propofol and sevoflurane combined anesthesia.Methods Thirty-two were randomized into 3 groups:midazolam group (group M,n =8),propofol P,n =12) S,n =12).Midazolam 1-5 mg,vecuronium 0.15 mg/kg fentanyl 10-20 μg/kg injected intravenously M.Propofol 1-2 mg/kg,vecuronium 10 P.In S,the inhaled until eyelash reflex disappeared,the end-tidal concentration of was 0.5 ％-2.0％,and...
Objective To investigate the effects of GHRP-2 on sepsis induced acute lung injury (ALI) rats.Methods SD rats weighting 200-250 g were randomly divided into four groups ( n =12 per group):saline control group,ALI group,GHRP-2/ALI group,GHRP 2 group.ALI was by administering 7.5 mg/kg lipopolysaccharide (LPS) via vein.The subcutaneously treated with 100 μg/kg 30 min before LPS administration.Rats sacrificed at 6 h after administration,blood obtained to observe blood gas,lung tissue used...