A5013492170- Chemical Thermodynamics and Molecular Structure
- thermodynamics and calorimetric analyses
- Phase Equilibria and Thermodynamics
- Thermodynamic properties of mixtures
- Protein Interaction Studies and Fluorescence Analysis
- Thermal and Kinetic Analysis
- Radiation Effects and Dosimetry
- Free Radicals and Antioxidants
- Geology and Paleoclimatology Research
- Geomagnetism and Paleomagnetism Studies
- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Biochemical effects in animals
- Lipid Membrane Structure and Behavior
- Advanced biosensing and bioanalysis techniques
- Crystallography and molecular interactions
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- Luminescence Properties of Advanced Materials
- Image Processing and 3D Reconstruction
- Thermochemical Biomass Conversion Processes
- Protein purification and stability
- Chemical and Physical Properties in Aqueous Solutions
- Diatoms and Algae Research
Romanian Academy
2014-2024
University of Bucharest
2023-2024
Weatherford College
2024
Institute of Physical Chemistry
2021-2022
Understanding nanomaterial (NM)-protein interactions is a key issue in defining the bioreactivity of NMs with great impact for nanosafety. In present work, complex phenomena occurring at bio/nano interface were evaluated simple case study focusing on NM-protein binding thermodynamics and protein stability three representative metal oxide NMs, namely, zinc (ZnO; NM-110), titanium dioxide (TiO2; NM-101), silica (SiO2; NM-203). The thermodynamic signature associated NM interaction an abundant...
Abstract. Solid biomass fuels are economical and practical renewable energy sources. Exploitation of agricultural as a fuel offers considerable advantages in different domains supply far the climate is involved. In this study we intended to investigate feasibility alternative residues grape pomace corn cob pellets with addition sawdust, starch, waste rapeseed oil examine how these additives affects calorific powers physical properties. Sawdust, was 10 %. Pellets were produced by manual...
The aim of the present study was to manufacture new orally disintegrating tablets containing nimodipine-hydroxypropyl-β-cyclodextrin and nimodipine-methyl-β-cyclodextrin inclusion complexes. For obtaining a better quality manufactured tablets, three methods preparation complexes, in 1:1 molar ratio, were used comparatively; namely, solid-state kneading method two liquid state coprecipitation lyophilization techniques. physical chemical properties obtained as well their mixtures, investigated...
The development of new orally dispersible tablets containing amlodipine (AML) inclusion complexes in hydroxypropyl-β-cyclodextrin (HP-β-CD) and methyl-β-cyclodextrin (Me-β-CD) was studied. methods obtaining the physical chemical properties using two cyclodextrins investigated separately. Solid were obtained by three methods: kneading, coprecipitation, lyophilization, at a molar ratio 1:1. For comparison, mixture same prepared. aim complexation process to improve drug solubility. As...
The novelty in this study is the development of new orodispersible tablets containing nifedipine (NIF) as active ingredient. Initially, formation inclusion complexes between and two derivatives beta-cyclodextrin, namely, hydroxypropyl-β-cyclodextrin (HP-β-CD) methyl-β-cyclodextrin (Me-β-CD), was established. Inclusion were prepared by different procedures: kneading, coprecipitation lyophilization methods, using a 1:1 molar ratio among drug cyclodextrin compounds. A physical mixture also...
Abstract The recent focus in the development of novel nanosystems for biomedical applications lays firmly on their interactions with biomolecules. Thermodynamic parameters driving interaction between nanoparticles and proteins provide insights into complex processes at bio/nanointerface. present work aims to investigate binding mechanisms dominant contributions that determine adsorption during a model protein, is, bovine serum albumin, new type drug delivery systems, Vitamin E/sphingomyelin...
The exposure of nanoparticles (NPs) to biological fluids leads the formation a protein coating that is known as corona (PC). Since PC influenced by physicochemical properties nanoparticles, understanding interplay factors participate in this process crucial for development nanomaterials cell-targeted delivery vehicles. In general, it accepted complex and dynamic process, which depends on composition medium NP mainly size, shape, superficial charge. Interestingly, although interaction between...
The results of the density measurements for pair systems containing nitromethane with 1,1,2,2-tetrachloroethane, 1,1,1-trichloroethane, chloroform, 1,2-dichloroethane, 1,3-dichloropropane, 1,4-dichlorobutane, 1-chlorobutane, and 1-chloropentane at T = (298.15, 308.15, 318.15) K atmospheric pressure on entire compositional range are reported. derived excess molar volumes, VE, positive + binary mixtures, they negative other two systems: all three studied temperatures. volumes have been...
Isothermal vapor–liquid equilibrium (VLE) data are reported at three temperatures, (343.15, 353.15, and 363.15) K, for the binary mixtures containing nitromethane or nitroethane with 1,3-dichloropropane. For measurements an all-glass ebulliometer was used, which allows sampling from both phases in equilibrium. The experimental were correlated using nonrandom two-liquid (NRTL) universal quasichemical activity coefficient (UNIQUAC) excess Gibbs energy models by means of maximum likelihood...
The deep eutectic solvent (DES)-based biocatalysis of l-menthol acylation was designed for the production fatty acid l-menthyl ester (FME) using methyl (FAME). biocatalytic reaction assisted by a lipase enzyme in DES medium. ւՒ-menthol and acids (e.g., CA-caprylic acid; OA-oleic LiA-linoleic LnA-linolenic acid) were combined binary mixture DES. In this way, provided nonpolar environment requested homogeneity system with reduced impact on environment. screening demonstrated better performance...
The combustion energy of histidine enantiomers (L and D) their racemic mixture was measured experimentally. following values for the enthalpies formation corresponding to crystalline state were derived = −451.7, D −448.7, DL −451.5 kJ·mol −1 ), information concerning stability obtained by correlating above thermochemical quantity with structure molecules using group additivity scheme. samples characterized a simultaneous thermogravimetry (TG) coupled differential scanning calorimetry (DSC)...
Thermal analysis of two dipeptides having alanine (Ala) as first term, using combustion calorimetry method and simultaneous TG-DSC measurements, have been carried out. The enthalpies formation, the quantities related to decomposition processes these compounds, were compared with those free –α-amino acids contained in dipeptides.Information about stability influence components on was obtained.
Abstract Unmixing of remanent magnetization curves, either isothermal (IRM) or backfield IRM, is widely used in rock magnetic and environmental studies to discriminate between coercivity components different origins. However, the wide range physical properties natural particles gives rise an ambiguous interpretation these components. To reduce this ambiguity provide a straightforward terms domain state, interactions, constituent phases, we combined IRM unmixing with nonlinear Preisach maps...
The effect of resveratrol (RESV) on α-lactalbumin (α-LA) thermal stability was evaluated using differential scanning calorimetry (DSC), circular dichroism (CD) and dynamic light scattering (DLS) measurements. Complementary information offered by molecular docking served to identify the binding site ligand native structure protein type interacting forces. DSC thermograms revealed a double-endotherm pattern with partial overlapping two components. most relevant RESV is manifested in narrowing...