A5040464140- Toxin Mechanisms and Immunotoxins
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Endoplasmic Reticulum Stress and Disease
- Skin Protection and Aging
- Advanced biosensing and bioanalysis techniques
- Chemical Safety and Risk Management
- Dermatologic Treatments and Research
- CNS Lymphoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Nanoparticles: synthesis and applications
- Signaling Pathways in Disease
- Microplastics and Plastic Pollution
- Research Data Management Practices
- Barrier Structure and Function Studies
- Hereditary Neurological Disorders
- Advancements in Transdermal Drug Delivery
- Scientific Computing and Data Management
- Bee Products Chemical Analysis
- Transgenic Plants and Applications
- Epilepsy research and treatment
- Immunodeficiency and Autoimmune Disorders
- Data Quality and Management
- Chemistry and Chemical Engineering
- Advanced Drug Delivery Systems
GAIKER Technology Centre
2019-2025
Hospital Luis Calvo Mackenna
2022
University of the Basque Country
2018-2020
Achucarro Basque Center for Neuroscience
2018
Bilastine is a non-sedating, highly selective H1-antihistamine with proven efficacy and safety in treating allergic rhinoconjunctivitis urticaria adults children. Allergic conjunctivitis, common ocular condition, negatively impacts quality of life. Topical eye drops are the standard treatment, though bioavailability often low. Incorporating biopolymers such as hyaluronic acid (HA) into topical formulations enhances adhesive properties, prolongs retention on surface, ultimately improves drug...
Allergic conjunctivitis (AC) is the most common form of allergic eye disease and an increasingly prevalent condition. Topical drop treatments are usual approach for managing AC, although their impact on ocular surface not frequently investigated. The aim this study was to perform a comparative physicochemical characterization, in vitro biological evaluations primary conjunctival corneal epithelial cells new multidose preservative-free bilastine 0.6% main commercially available drops. MTT...
In vitro blood–brain barrier (BBB) models are a useful tool to screen the permeability and toxicity of new drugs. Currently, many different in BBB coexist, but none stands out as being notably better than rest. Therefore, there is still need evaluate quality under various conditions assess their ability mimic vivo situation. this study, two brain endothelial cell lines (bEnd.3 hCMEC/D3) epithelial-like (MDCKII Caco-2) were selected for modelling purposes. They grown monolayers single type,...
The human IL22RA2 gene co-produces three protein isoforms in dendritic cells (IL-22 binding protein-1, IL-22BPi2 and IL-22BPi3). Two of these, IL-22BPi3, are capable neutralizing the biological activity IL-22. function IL-22BPi1, which differs from through an in-frame 32-amino acid insertion provided by alternatively spliced exon, remains unknown. We demonstrate that IL-22BPi1 is secreted detectably, but at much lower levels than IL-22BPi2, unlike largely retained endoplasmic reticulum (ER)....
Millions of people suffer from different types skin diseases worldwide. In the last decade, development nanocarriers has been focus pharmaceutical and cosmetic industries to enhance performance their products, meet consumers’ demands. Several delivery systems have developed improve efficiency minimize possible side effects. this study, retinyl palmitate Dead Sea water loaded nanoemulsions were as carriers treat conditions such photoaging, psoriasis, or atopic dermatitis. Toxicity profiles...
Introduction: Skin as the major barrier between internal and external environments protects our body from injuries. Ultraviolet B (UVB) radiation is majorly responsible for photoaging closely associated with oxidative stress, inflammation, DNA damage. The progression in field of biological therapies has led to emergence new autologous based on growth factors. An topical serum (ATS) plasma rich factors (PRGF) technology also been developed regenerative properties. Objective: aim this study...
The IL22RA2 locus is associated with risk for multiple sclerosis (MS) but causative variants are yet to be determined. In a single nucleotide polymorphism (SNP) screen of this in Basque population, rs28385692, rare coding variant substituting Leu Pro at position 16 emerged significantly (p = 0.02). This located the signal peptide (SP) shared by three secreted protein isoforms produced (IL-22 binding protein-1(IL-22BPi1), IL-22BPi2 and IL-22BPi3). Genotyping was extended Europe-wide...
Of the three interleukin-22 binding protein (IL-22BP) isoforms produced by human IL22RA2 gene, IL-22BPi2 and IL-22BPi3 are capable of neutralizing IL-22. The longest isoform, IL-22BPi1, does not bind IL-22, is poorly secreted, its retention within endoplasmic reticulum (ER) associated with induction an unfolded response (UPR). Therapeutic modulation production may be beneficial in IL-22-dependent disorders. Recently, we identified ER chaperones GRP94 cyclophilin B interactomes both IL-22BPi1...