A5016017563- Nanoparticles: synthesis and applications
- Air Quality and Health Impacts
- Ocular Oncology and Treatments
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Plant Genetic and Mutation Studies
- Cancer Genomics and Diagnostics
- Recycling and Waste Management Techniques
- Bryophyte Studies and Records
- Microplastics and Plastic Pollution
- Animal testing and alternatives
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Lichen and fungal ecology
- Healthcare and Environmental Waste Management
- Chemical Safety and Risk Management
- Plant nutrient uptake and metabolism
- Botany and Plant Ecology Studies
- 3D Printing in Biomedical Research
- Antimicrobial agents and applications
- Plant Molecular Biology Research
- Chromosomal and Genetic Variations
- Microtubule and mitosis dynamics
- Photosynthetic Processes and Mechanisms
- Analytical chemistry methods development
Institut national de l'environnement industriel et des risques
2011-2023
Inserm
2012
Institut Curie
2012
University of California, Los Angeles
2009
Institut National de la Recherche Agronomique
2007
Institut Jean-Pierre Bourgin
2007
Département Biologie et Amélioration des Plantes
2006
Abstract Titanium dioxide (TiO2) nanoparticles are manufactured worldwide in large quantities for use a wide range of applications including pigment and cosmetic manufacturing. Although TiO2 is chemically inert, can cause negative health effects, such as respiratory tract cancer rats. However, the mechanisms involved TiO2-induced genotoxicity carcinogenicity have not been clearly defined poorly studied vivo. The present study investigates nanoparticles–induced genotoxicity, oxidative DNA...
Recently, much progress has been made to develop more physiologic in vitro models of the respiratory system and improve simulation particle exposure through inhalation. Nevertheless, field nanotoxicology still suffers from a lack relevant methods predict accurately effects observed vivo, especially after exposure. In this context, aim our study was evaluate if exposing pulmonary cells at air-liquid interface aerosols inhalable poorly soluble nanomaterials generates different toxicity...
Abstract Purpose: To develop a molecular tool to detect circulating tumor–derived DNA (ctDNA) in the plasma from patients with uveal melanoma as marker of tumor burden and monitor treatment efficacy. Experimental Design: A real-time PCR was developed on basis bidirectional pyrophosphorolysis-activated polymerization (bi-PAP) for quantification ctDNA using 3′blocked primer pairs specific 3 recurrent mutually exclusive mutations Gα subunits GNAQ GNA11. Results: Sensitivity specificity bi-PAP...
MSH2 is a central component of the mismatch repair pathway that targets mismatches arising during DNA replication, homologous recombination (HR) and in response to genotoxic stresses. Here, we describe function moss Physcomitrella patens , as deciphered by analysis loss mutants. Ppmsh2 mutants display pleiotropic growth developmental defects, which reflect genomic instability. Based on APT gene, estimated this mutator phenotype be at least 130 times higher than wild type. We also found...
Animal models remain at that time a reference tool to predict potential pulmonary adverse effects of nanomaterials in humans. However, context reduction the number animals used experimentation, there is need for reliable alternatives. In vitro using lung cells represent relevant alternatives assess nanomaterial acute toxicity by inhalation, particularly since advanced methods and have been developed. Nevertheless, ability experiments replace animal experimentation predicting human still...
Inhaled titanium dioxide (TiO2) nanoparticles (NPs) can have negative health effects, and been shown to cause respiratory tract cancer in rats. Inflammation has linked oxidative stress, both described as possible mechanisms for genotoxicity of NPs, but rarely examined side-by-side animal studies. In the present study, a wide range complementary endpoints performed study TiO2 P25 NP-induced lung overload non-overload conditions. Additionally, burden, inflammation, cytotoxicity stress also...
The quality and relevance of nanosafety studies constitute major challenges to ensure their key role as a supporting tool in sustainable innovation, subsequent competitive economic advantage. However, the number apparently contradictory inconclusive research results has increased past few years, indicating need introduce harmonized protocols good practices community. Therefore, we aimed evaluate if best-practice training inter-laboratory comparison (ILC) performance...
An efficient biocidal paint is prepared. Antibacterial activity provided by silver nanoparticles (AgNPs) nucleated on a bio-based substrate (cellulose nanocrystals, CNCs), dispersed in an amount as low possible aqueous suspension.
<p>PDF file, 32KB, Correlation between ctDNA and cfcDNA levels in UM patients.</p>
<p>PDF file, 32KB, Correlation between ctDNA and cfcDNA levels in UM patients.</p>
<div>Abstract<p><b>Purpose:</b> To develop a molecular tool to detect circulating tumor–derived DNA (ctDNA) in the plasma from patients with uveal melanoma as marker of tumor burden and monitor treatment efficacy.</p><p><b>Experimental Design:</b> A real-time PCR was developed on basis bidirectional pyrophosphorolysis-activated polymerization (bi-PAP) for quantification ctDNA using 3′blocked primer pairs specific 3 recurrent mutually exclusive...
<div>Abstract<p><b>Purpose:</b> To develop a molecular tool to detect circulating tumor–derived DNA (ctDNA) in the plasma from patients with uveal melanoma as marker of tumor burden and monitor treatment efficacy.</p><p><b>Experimental Design:</b> A real-time PCR was developed on basis bidirectional pyrophosphorolysis-activated polymerization (bi-PAP) for quantification ctDNA using 3′blocked primer pairs specific 3 recurrent mutually exclusive...
Strategic Watch OMNT–Environmental, Health and Safety Impacts of Nanoparticles; n°11; September 2013; 1-9