A5019855634- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Renal Transplantation Outcomes and Treatments
- Urticaria and Related Conditions
- Vasculitis and related conditions
- Adolescent and Pediatric Healthcare
- Immunodeficiency and Autoimmune Disorders
- Chronic Kidney Disease and Diabetes
- Pneumocystis jirovecii pneumonia detection and treatment
- Systemic Lupus Erythematosus Research
- Pregnancy and Medication Impact
- Chronic Lymphocytic Leukemia Research
- Chronic Disease Management Strategies
- Cytomegalovirus and herpesvirus research
- Heart Failure Treatment and Management
- Acute Kidney Injury Research
- Healthcare Policy and Management
- Endometriosis Research and Treatment
- Central Venous Catheters and Hemodialysis
- Ion Transport and Channel Regulation
- Electrolyte and hormonal disorders
- Liver Diseases and Immunity
- Neonatal Health and Biochemistry
- Organ Transplantation Techniques and Outcomes
- Clinical Nutrition and Gastroenterology
Sorbonne Université
2019-2025
Hôpital Armand-Trousseau
2019-2025
Assistance Publique – Hôpitaux de Paris
2019-2024
Agence de la Biomédecine
2019-2022
Hôpital Bretonneau
2020-2021
Université Sorbonne Nouvelle
2020
Abstract Background Idiopathic nephrotic syndrome (INS) in children is the most common glomerular disease and characterized by recurrent relapses. There no community consensus on treatment of relapsing forms children, unlike that for initial presentation. To date, available treatments only enable patients to be maintained remission, rather than modifying course disease; therefore, more therapeutic trials are needed. The Société de Néphrologie Pédiatrique (SNP) decided implement within its...
Abstract Introduction Juvenile systemic lupus erythematosus (j-SLE) is a rare chronic autoimmune disease affecting multiple organs. Ranging from minor features, such as headache or mild cognitive impairment, to serious and life-threatening presentations, j-neuropsychiatric SLE (j-NPSLE) therapeutic challenge. Thus, the diagnosis of NPSLE remains difficult, especially in pediatrics, with no specific biomarker yet validated. Objectives To identify central nervous system (CNS) biomarkers...
Health policy-making require careful assessment of chronic kidney disease (CKD) epidemiology to develop efficient and cost-effective care strategies. The aim the present study was use RENALGO-EXPERT algorithm estimate global prevalence CKD in France. An expert group developed based on healthcare consumption. This has been applied French National claims database (SNDS), where no biological test findings are available a national for years 2018-2021. CONSTANCES cohort (+219 000 adults aged...
Socioeconomic status (SES) is recognized as an important determinant of kidney health. We aimed to evaluate the association social deprivation with different indicators at replacement therapy (KRT) initiation in French pediatric metropolitan population.
Steroid-resistant nephrotic syndrome recurrence post-transplant unresponsive to immunoadsorption is a dilemma, and no reliable treatment strategy has been identified induce remission so far.A 2-year-old girl presented first with idiopathic syndrome. She did not reach after 30 days of oral steroids remained resistant steroid pulses, tacrolimus, IV cyclosporine, sessions plasma exchange. Bilateral nephrectomy was performed because extrarenal complications. Two years later, she received an...
Objective Juvenile systemic lupus erythematosus (j-SLE) is a rare chronic auto-immune disease involving several organs. Neuropsychiatric (NP) SLE (NPSLE) frequent in j-SLE and associated with increased morbidity/mortality. Although NPSLE classification criteria exist, attributing NP features to remains major challenge. The study objective thoroughly describe j-NPSLE patients assist their diagnosis. Methods This 4-year retrospective monocentric of patients. events were attributed using...
ABSTRACT Background Inherited kidney diseases (IKDs) and congenital anomalies of the urinary tract (CAKUT) are causes failure requiring replacement therapy (KRT) that major renal registries usually amalgamate into primary disease(PRD) category ‘miscellaneous’ or in glomerulonephritis pyelonephritis categories. This makes IKDs invisible (except for polycystic disease) may negatively influence use genetic testing, which identify a cause some CAKUT. Methods We re-examined aetiology KRT by...
Several models have been proposed to predict kidney graft failure in adult recipients but none younger recipients. Our objective was propose a dynamic prediction model for young transplant recipients.We included 793 waitlisted before the age of 18 years who received first transplantation 21 France 2002-13 and survived >90 days with functioning graft. We used Cox including baseline predictors only (sex, at transplant, primary disease, dialysis duration, donor type age, human leucocyte antigen...
In this retrospective cohort study, we analyze the early humoral and cellular response in 64 adolescents KTx recipients, after two or three doses of mRNA vaccine BNT162b2 against different variants COVID-19. After 2 doses, 77.8% % children with no history infection had a positive median anti-S IgG level 1107 (IQR, 593-2,658) BAU/mL. All patients responded higher (3,265 1,492-8,178) BAU/mL). non-responders 75% third dose Ab titer at 355 140-3,865 Neutralizing activity was significantly lower...
Abstract BACKGROUND AND AIMS In children with Steroid Sensitive Nephrotic Syndrome (SSNS), relapse after the first flare occurs in 80% of cases, whatever dosage or duration initial steroid therapy. Therefore, there is an unmet need for early interventions to reduce incidence and subsequent steroids immunosuppressive drug exposure. Levamisole antihelmintic immunomodulatory action that reduces relapses frequent steroid-dependant NS. NEPHROVIR-3 trial assess efficacy levamisole increasing...