A5055936475- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Use and Resistance
- Redox biology and oxidative stress
- Pneumonia and Respiratory Infections
- Computational Drug Discovery Methods
- Nanoparticles: synthesis and applications
- Antibiotics Pharmacokinetics and Efficacy
- Enzyme-mediated dye degradation
- Microbial Metabolism and Applications
- Travel-related health issues
- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- Antimicrobial Resistance in Staphylococcus
- Education and Technology Integration
- Oral microbiology and periodontitis research
- Chromium effects and bioremediation
- Blood groups and transfusion
- Tuberculosis Research and Epidemiology
- SARS-CoV-2 detection and testing
- Seed and Plant Biochemistry
- Biomedical Research and Pathophysiology
- Phytochemical and Pharmacological Studies
- Complement system in diseases
- Hibiscus Plant Research Studies
Umm al-Qura University
2022-2025
Dalhousie University
2015-2021
Izaak Walton Killam Health Centre
2019-2021
Nova Scotia Health Authority
2020-2021
Cardiovascular Institute of the South
2014
Water pollution due to textile dyes is a serious threat every life form. Bacteria can degrade and detoxify toxic present in effluents wastewater. The study aimed evaluate the degradation potential of eleven bacterial strains for azo dye methyl red. optimum efficiency was obtained using P. aeruginosa. It found from initial screening results that aeruginosa most potent strain with 81.49% activity hence it subsequently used other experiments. To optimize conditions, number experiments were...
The azo dye orange II is used extensively in the textile sector for coloring fabrics. High concentrations of it are released into aqueous environments through effluents. Therefore, its removal from wastewater and effluents necessary. Herein, initially, we tested 11 bacterial strains their capabilities degradation dye. It was revealed preliminary data that B. subtilis can more potently degrade selected dye, which thus subsequent experiments. To achieve maximum decolorization, experimental...
Infectious disease is one of the greatest causes morbidity and mortality worldwide, with emergence antimicrobial resistance, situation worsening. In order to prevent this crisis, resistance needs be monitored carefully control spread multidrug-resistant bacteria. Therefore, in study, we aimed determine prevalence infection caused by Klebsiella pneumoniae investigate profile pattern K. last eleven years. This retrospective study was conducted a tertiary hospital Makkah, Saudi Arabia. Data...
Pseudomonas aeruginosa (P. aeruginosa) is a common causative pathogen in healthcare settings and displays increasing levels of resistance to antimicrobial drugs. Its capacity resist has been reported multiple locations across the world. This study evaluates current antibiotic seeks understand patterns context clinical isolates P. aeruginosa.All were cultured at 37 °C for 24 h different media: blood sheep agar, McConkey cystine-lactose-electrolyte-deficient agar (CLED), bacterial...
Malaria is a parasitic infection that may result in an acute, life-threatening illness. It major public health problem the tropical world. The disease caused by parasites of genus Plasmodium and transmitted female Anopheles mosquitoes. Saudi Arabia elimination phase malaria control. Several parts report cases imported among travelers visitors. city Makkah has population about 2.3 million. Moreover, over 6 million religious visitors from different world visit annually. During COVID-19...
Fabrication of plant-based metal nanoparticles has yielded promising results, establishing this approach as viable, sustainable, and non-toxic in the biomedical sector for targeted drug delivery, diagnostic imaging, biosensing, cancer therapy, antimicrobial treatments.
Dengue fever is caused by four common serotypes of the dengue virus (DENV-1, DENV-2, DENV-3, and DENV-4). Patients infected with one serotype may develop lifelong serotype-specific protective immunity. However, they remain susceptible to reinfection other serotypes, often increasing risk severe forms dengue. This cross-sectional study investigates prevalence in patients who presented at Makkah hospitals between April 2023 May 2024. Data were collected from medical records Regional Laboratory...
Acinetobacter baumannii is pathogen of global concern. It causes infection, especially among immunocompromised individuals in intensive care units, due to its ability survive for long periods on hard surfaces and under a wide range environmental conditions become resistant almost all the available antibiotics used clinical practice. Objectives: This study aims address gap A. surveillance Saudi Arabia by tracking prevalence, patterns, trends acquired resistance at healthcare facility western...
This study encapsulates an in-depth correlation analysis for the biological activities (cytotoxicity, antimicrobial, and α-amylase inhibition) vs. phytochemical classes (flavonoids "FV" alkaloid "AL") present in fenugreek seed extract. Cell cultures different cell lines were used to assess cytotoxicity selectivity (IC50 value), agar diffusion assay was determine MIC MBC bacteria fungi, whereas inhibition studied evaluate antidiabetic potential forty-five origins of extracts. An in-house...
Plant fractions have a diversity of biomolecules that can be used to make complicated reactions for the bioactive fabrication metal nanoparticles (NPs), in addition being beneficial as antioxidant medications or dietary supplements. The current study shows Urtica dioica (UD) and biologically synthesized silver (AgNPs) UD antibacterial properties against bacteria (Escherichia coli Pseudomonas putida) Drosophila melanogaster (Oregon R+). According their ability scavenge free radicals, DPPH,...
Bixa orellana (B. Orellana) is a frequently utilized plant that has grown in significance pharmaceutical applications. The leaves extract of B. was used the current study for preliminary phytochemical analysis terms both quantitative and qualitative, which indicates presence phenols, alkaloids, flavonoids. Furthermore, demonstrated antifungal activity at 30 mm zone clearance against Candida albicans antibacterial 16 Bacillus nakamuria by well diffusion method different strains. showed MIC 20...
This study was aimed at determining the prevalence estimate and association of transfusion-transmitted infections (TTIs) with ABO Rh blood groups among donors King Faisal Specialist Hospital Research Center (KFSH & RC) in western region Saudi Arabia. A retrospective conducted bank center KFSH RC from 1 January 2013 to 31 December 2019. Data on group testing, serological molecular investigations, assays, nucleic acid testing (NATs), socio-demographic information were gathered. During period,...
The number of reports menstrual changes after COVID-19 vaccination in the Saudi population is still unknown. Therefore, this study aimed to assess effect vaccine(Pfizer, AstraZeneca, and Moderna) on cycle among females Arabia.
Streptococcus mutans in dental biofilms often faces life-threatening threats such as killing by antimicrobial molecules from competing species or the host. The ability of S. to cope with is crucial for its survival and persistence biofilms. By screening a transposon mutant library, we identified 11 insertion mutants that were sensitive bacitracin. Two these mutants, XTn-01 XTn-03, had an independent same locus, SMU.244, which encoded homologue undecaprenyl pyrophosphate phosphatase (UppP)....
The currently available methods for the detection of Streptococcus pneumoniae are labour-intensive, and involve time-consuming steps needing skilled technicians to perform assays. Therefore, we developed a rapid lateral flow based immunochromatographic test strip S. using pneumolysin monoclonal antibody capture approach. Methodology − was designed by assembling sample pad, conjugation nitrocellulose membrane adsorbent pad supported plastic backing card. Optimization control spot done three...
New Delhi metallo-beta-lactamase-1 (NDM1) confers resistance to several bacterial species against a broad range of beta-lactam antibiotics and turning them into superbugs that pose significant threat healthcare systems worldwide. As such, it is potentially relevant biological target for counteracting infections. Given the lack effective treatment options NDM1 producing bacteria, finding reliable inhibitor enzyme crucial. Using molecular dynamics simulations, binding selectivities affinities...
The ability of Streptococcus gordonii to cope with oxidative stress is important for survival and persistence in dental plaque. In this study, we used mutational, phenotypic, biochemical approaches characterize the role a methionine sulfoxide reductase (MsrAB) proteins encoded by genes msrAB operon an adjacent tolerance S. gordonii. results showed that MsrAB four other operons are needed protection from H2O2 sulfoxide. These five formed reducing pathway was tolerance, biofilm formation, oral...
Streptococcus pneumoniae is one of the major precarious pathogens accountable for over 1.2 million fatalities annually. The key drivers pneumococcal vaccine development involve high morbidity and mortality in cases, especially very young children elderly. In this study, immunoinformatics was integrated with subtractive proteomics to find antigenic proteins designing a multi-epitope against S. pneumoniae. As prospective targets, developed pipeline identified two proteins, i.e.,...
In Covid-19, the pathological effect of SARS-CoV-2 infection is arbitrated through direct viral toxicity, unusual immune response, endothelial dysfunction, deregulated renin-angiotensin system [RAS], and thrombo-inflammation, leading to acute lung injury (ALI), with a succession respiratory distress syndrome (ARDS) in critical conditions. C1 esterase inhibitor (C1INH) protease that inhibits spontaneous activation complement contact systems kinin pathway, clotting, fibrinolytic systems....
The SARS-CoV-2 spike (S) glycoprotein with its mobile receptor-binding domain (RBD), binds to the human ACE2 receptor and thus facilitates virus entry through low-pH-endosomal pathways. high degree of mutability has raised concern among scientists medical professionals because it created doubt about effectiveness drugs vaccinations designed specifically for COVID-19. In this study, we used computational saturation mutagenesis approach, including structure-based free energy calculations...
Infections caused by Pseudomonas aeruginosa may be either acquired in the community or contracted a healthcare setting. Multidrug-resistant (MDR) P. is growing problem; new treatment approach required to tackle this. Combination therapy of antibiotics and nanoparticle thus applied overcome this problem. Therefore, study was planned evaluate synergistic effect AgNPs along with different against MDR aeruginosa. A total 120 surgical burn wound samples were collected from tertiary care hospital....