A5028762623- Selenium in Biological Systems
- Food Allergy and Anaphylaxis Research
- Heavy Metal Exposure and Toxicity
- Mercury impact and mitigation studies
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Meat and Animal Product Quality
- Heavy metals in environment
- Trace Elements in Health
- Nuclear Receptors and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Xenotransplantation and immune response
- Mindfulness and Compassion Interventions
- Digital Mental Health Interventions
- Neurogenesis and neuroplasticity mechanisms
- Inflammasome and immune disorders
- Mast cells and histamine
- T-cell and B-cell Immunology
- Vasculitis and related conditions
- IgG4-Related and Inflammatory Diseases
- Cytokine Signaling Pathways and Interactions
- RNA Interference and Gene Delivery
- Coal and Its By-products
Thu Dau Mot University
2018-2023
Dalat University
2018-2023
Hue University of Agriculture and Forestry
2023
The University of Texas Southwestern Medical Center
2008-2022
NorthShore University HealthSystem
2022
Erasmus MC
2022
Catharina Ziekenhuis
2022
Radboud University Nijmegen
2022
Erasmus University Rotterdam
2022
Amsterdam University Medical Centers
2022
The loss of nigral dopaminergic (DA) neurons in idiopathic Parkinson's disease (PD) is believed to result from interactions between genetic susceptibility and environmental factors. Evidence that inflammatory processes modulate PD risk comes prospective studies suggest higher plasma concentrations a number proinflammatory cytokines correlate with an increased developing chronic nonsteroidal anti-inflammatory drug regimens reduce the incidence PD. Although loss-of-function mutations parkin...
Abstract Patients with I g E antibodies against the carbohydrate epitope galactose‐α‐1,3‐galactose (α‐ G al) have reported severe allergic reactions after consumption of red meat. Investigations revealed associations between to α‐ al and tick bites. We provide first direct evidence that is present within ticks thus potentially explaining relationship exposure sensitization al, development meat allergy as a secondary phenomena. Serum from S wedish patients delayed was included in study. A...
Understanding the bioavailability of selenium (Se) in soil–plant system plays a vital role phytoremediation and agronomic biofortification strategies. This review aimed to (a) discuss effect various soil parameters on Se, its uptake translocation relation plant species, genotypes, growth stages, management regimes; (b) examine indices associated with Se bioavailability. In addition, we particularly discussed potential methods for regulating Se. Such include application agricultural residue,...
Inflammation and oxidative stress have been implicated in the pathophysiology of Parkinson's disease (PD) inhibition microglial activation attenuates degeneration dopaminergic (DA) neurons animal models PD. Loss-of-function mutations parkin gene, which encodes an E3 ubiquitin ligase, cause autosomal recessive parkinsonism. While most studies on Parkin focused its function neurons, here we demonstrate that mRNA protein is detectable brain-resident microglia peripheral macrophages. Using...
Abstract Background Red meat allergy presents a novel form of food with severe delayed allergic reactions where IgE antibodies are directed against the carbohydrate α‐ G al epitope. Food preparation and processing can influence allergenicity proteins. The aim this study was to characterize proteomic profile different beef preparations investigate their α‐Gal reactivity potential allergenicity. Methods Extracts from raw, boiled, fried, medium rare prepared were assessed by 2 D PAGE for...
Abstract Background Recent animal and human studies implicate chronic activation of microglia in the progressive loss CNS neurons. The inflammatory mechanisms that have neurotoxic effects contribute to neurodegeneration need be elucidated specifically targeted without interfering with neuroprotective glial activities. Synthetic triterpenoid analogs oleanolic acid, such as methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate (CDDO-Me, RTA 402) potent anti-proliferative differentiating on tumor...
Land-use and land-cover (LULC) mapping in the complex area is a challenging task due to mixed vegetation patterns, rough mountains with fast-flowing rivers. In Vietnam, LULC update not frequently. this study, we applied supervised machine learning (Random forest—RF) approach Thanh Hoa province, Vietnam from 2011 2015 utilizing multi-temporal Normalized Difference Vegetation Index (NDVI) data MODIS, combined topographic features. Random forest classification (RFC) reached total prediction...
Galactose-α-1,3-galactose (α-Gal) is a mammalian carbohydrate with significance in novel type of food allergy. Patients IgE against α-Gal report severe allergic symptoms 3-6 h after consumption red meat. We investigated whether from meat patients recognizes other glycans than or the plant kingdom and insects importance found that none 24 had an antibody response abundant glycan N-glycolylneuraminic acid cross-reactive determinants venom sources (nCup 1, nArt v MUXF3). Deglycosylation...
Processing of pro-interleukin (IL)-1β and IL-18 is regulated by multiprotein complexes, known as inflammasomes. Inflammasome activation results in generation bioactive IL-1β IL-18, which can exert potent pro-inflammatory effects. Our aim was to develop a whole blood-based assay study the inflammasome vitro that also be used an clinical studies. We show blood suitable milieu primary human monocytes. demonstrated unprocessed cells stimulated activate addition adenosine 5'-triphosphate (ATP)...
We investigated whether adipose-derived adult stromal (ADAS) are of neural crest origin and the extent to which Notch 1 regulates their growth differentiation. Mouse ADAS cells cultured in media formulated for stem (NSC) displayed limited capacity self-renewal, clonogenicity, neurosphere formation compared NSC from subventricular zone hippocampus. Although expressed Nestin, GFAP, NSE Tuj1 vitro, exposure differentiation supplements did not induce mature neuronal marker expression. In...
Tissue repair in the adult mammalian liver occurs two distinct processes, referred to as first and second tiers of defense. We undertook characterize changes molecular constituents extracellular matrix when hepatic progenitor cells (HPCs) respond a tier defense injury.We used transcriptional profiling on rat livers responding by (surgical removal 70% mass (PHx protocol)) (70% hepatectomy combined with exposure 2-acetylaminofluorene (AAF/PHx injury compared signatures untreated (control)...
Abstract Red meat allergy is characterized by an IgE response against the carbohydrate galactose-α-1,3-galactose (α-Gal), which abundantly expressed on glycoproteins from non-primate mammals. The mechanisms of how α-Gal processed and presented to immune system initiate allergic reaction are still unknown. aim this study was reveal whether presence epitopes protein surface influence antigen uptake processing in immature monocyte-derived dendritic cells (iMDDCs). Immature MDDCs were prepared...