A5082394619- Maternal and fetal healthcare
- Pregnancy and preeclampsia studies
- Cell Adhesion Molecules Research
- Receptor Mechanisms and Signaling
- Cancer, Hypoxia, and Metabolism
- Pelvic floor disorders treatments
- Cardiovascular Issues in Pregnancy
- Blood Pressure and Hypertension Studies
- Monoclonal and Polyclonal Antibodies Research
- Maternal and Perinatal Health Interventions
- Diabetes and associated disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Neuropeptides and Animal Physiology
- Pancreatic function and diabetes
- Computational Drug Discovery Methods
- Diabetes Management and Research
- Cardiac Valve Diseases and Treatments
- Biochemical and Structural Characterization
- Chemical Synthesis and Analysis
- Pregnancy-related medical research
- Cardiac Structural Anomalies and Repair
- Metabolomics and Mass Spectrometry Studies
- Neurological Complications and Syndromes
- Advanced NMR Techniques and Applications
University of Minnesota
2023
Baystate Medical Center
2021
Thomas Jefferson University
2021
Christiana Care Health System
2021
University of Massachusetts Chan Medical School
2021
Tufts University
2013-2019
Merrill (United States)
2015
Molecular Oncology (United States)
2015
Tufts Medical Center
2015
There has been an alarming and substantial increase in hypertensive disorders of pregnancy, which are a significant driver maternal morbidity mortality. The postpartum period is especially high-risk time, with >50% pregnancy-related deaths occurring during this period. American College Obstetricians Gynecologists suggests inpatient or equivalent monitoring blood pressures patients pregnancy for the immediate 72 hours again within 7 to 10 days postpartum. Hypertensive significantly contribute...
EHD1 mediates long-loop recycling of many receptors by forming signaling complexes using its EH domain. We report the design and optimization cyclic peptides as ligands for domain EHD1. demonstrate that improved affinity from cyclization allows fluorescence-based screening applications inhibitors. The peptide is also unusually well-structured in aqueous solution, demonstrated nuclear magnetic resonance-based structural models. Because few inhibitors have been described, these more potent...
The presence of ketosis and anion gap metabolic acidosis in individuals with diabetes indicates diabetic ketoacidosis (DKA). incidental detection such laboratory abnormalities persons should trigger an intentional evaluation for DKA. objective this retrospective cohort study was to assess the frequency which pregnant a abnormality potentially indicative DKA underwent complete assessment identify factors associated completion appropriate testing. Clinical characteristics were evaluated...
A patient with structural valve degeneration of an aortic bioprosthesis stenosis stage 3 underwent valve-in-valve transcatheter replacement (TAVR) at 29 weeks improvement. This is the first reported TAVR in third trimester. may be alternative to preterm delivery cases symptomatic stenosis.
Introduction Magnesium sulfate decreases the risk of eclampsia in patients with severe preeclampsia. There is a theoretical that magnesium increases intrapartum hemorrhage. We evaluated whether there was quantitative difference blood loss receiving at time cesarean delivery (CD) compared to those who were not.Materials and Methods A retrospective cohort study performed using database preeclampsia features or eclampsia. The primary outcome calculated estimated (cEBL) between received during...
The EHD1 protein coordinates the expression of surface proteins, such as β1 integrins, that are highly expressed in our human squamous cell carcinoma (SCC) line. mediates its effects via Eps15‐homology (EH) domain binds proteins containing an NPF sequence motif. This motif forms a β‐turn when bound to EH domain. Since cyclization promotes turn formation, we asked what extent constraining linear peptide formation and high affinity. We designed cyclized using model domain‐NPF complex. Linear...