A5056087303- Computational Drug Discovery Methods
- Wnt/β-catenin signaling in development and cancer
- Hippo pathway signaling and YAP/TAZ
- Hematopoietic Stem Cell Transplantation
- Health, Environment, Cognitive Aging
- Acute Myeloid Leukemia Research
- Cancer Cells and Metastasis
- Retinoids in leukemia and cellular processes
- Neonatal Respiratory Health Research
- Free Radicals and Antioxidants
- Cleft Lip and Palate Research
- Glutathione Transferases and Polymorphisms
- Neurological diseases and metabolism
- Acute Lymphoblastic Leukemia research
- Folate and B Vitamins Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
University Medical Center Utrecht
2023-2025
National Institute for Public Health and the Environment
2021-2025
Princess Máxima Center
2023-2024
Leiden University
2022-2023
Centre for Human Drug Research
2023
Abstract Afadin is a multimodal scaffolding protein with essential functions in cell–cell adhesion. Although its loss of expression has been linked to breast cancer invasion and metastasis, the underlying mechanisms driving tumour progression upon mutational ( AFDN ) cancers remains unclear. In current study we identified somatic frameshift mutation p .Lys630fs) an invasive sample that coincides expression. Functional studies E‐cadherin‐expressing cells show leads immature aberrant adherens...
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) can hijack the normal bone marrow microenvironment to create a leukemic niche which facilitates blast cell survival and promotes drug resistance. Bone marrow-derived mesenchymal stromal cells (MSCs) mimic this protective environment in ex vivo co-cultures with obtained from children newly diagnosed BCP-ALL. We examined potential mechanisms of protection by RNA sequencing flowsorted MSCs after co-culture BCP-ALL cells. Leukemic induced...
ABSTRACT Loss of E-cadherin ( CDH1 ) and the adherens junction (AJ) drive development progression invasive lobular breast cancer (ILC). However, approximately 40% retain wild type alleles, indicating that modulation other genes attenuates AJ during ILC etiology. To identify alternative drivers, we performed targeted sequencing in samples, based on a defined set 100 AJ, tight junction, desmosome designated as ‘Adhesome’. In 146 identified 62 cases (43%) with alleles which detected total 284...
Summary B-cell precursor acute lymphoblastic leukemia (BCP-ALL) can hijack the normal bone marrow microenvironment to create a leukemic niche which facilitates blast cell survival and promotes drug resistance. Bone marrow-derived mesenchymal stromal cells (MSCs) mimic this protective environment in ex vivo co-cultures with obtained from children newly diagnosed BCP-ALL. We examined potential mechanisms of protection by RNA sequencing flow-sorted MSCs after co-culture BCP-ALL cells. Leukemic...