A5055565693- Pelvic and Acetabular Injuries
- Bone fractures and treatments
- Shoulder Injury and Treatment
- Hip and Femur Fractures
- Pregnancy-related medical research
- Sports injuries and prevention
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Sarcoma Diagnosis and Treatment
- Mesenchymal stem cell research
- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Tendon Structure and Treatment
- Scoliosis diagnosis and treatment
- Shoulder and Clavicle Injuries
- Hernia repair and management
- Spinal Fractures and Fixation Techniques
- Connective tissue disorders research
- Bone health and osteoporosis research
- Bone and Joint Diseases
- Cancer Cells and Metastasis
- Periodontal Regeneration and Treatments
- Spine and Intervertebral Disc Pathology
- Lymphatic System and Diseases
- Venous Thromboembolism Diagnosis and Management
Instituto Nacional de Traumatologia e Ortopedia
2015-2025
Universidade de Rio Verde
2024
Universidade Federal Fluminense
2023
Universidade Federal do Rio de Janeiro
2023
National Institute of Traumatology & Orthopaedic Rehabilitation
2017
University of California, San Francisco
2016
Université de Bordeaux
2016
Hospital de São João
2013
Universidade do Porto
2013
Ministério da Saúde
2008
Abstract Background Musculoskeletal injuries (MSK-I) are a serious problem in sports medicine. Modifiable and non-modifiable factors associated with susceptibility to these injuries. Thus, the aim of this study was describe prevalence identify MSK-I, including tendinopathy joint muscle injuries, athletes. Methods In cross-sectional observational study, 627 athletes from rugby ( n = 225), soccer 172), combat 86), handball 82) water polo 62) were recruited at different training centres...
Abstract Background The repair of large bone defects is a major orthopedic challenge because autologous grafts are not available in amounts and harvesting often associated with donor-site morbidity. Considering that marrow stromal cells (BMSC) responsible for the maintenance turnover throughout life, we investigated at site critically sized segmental defect sheep tibia treated BMSCs loaded onto allografts. was created mid-portion tibial diaphysis eight adult sheep, were ex-vivo expanded...
During the pandemic of COVID-19, phylogenetic changes have been observed in characteristics virus, diagnosis and treatment disease. The clinical course severe form disease depends on several factors. This study characterized beginning setting for patient care COVID-19 a referral center one main capital cities Brazil. In addition, were evaluated factors associated with mortality, length stay, diagnostic outcome.A cross-sectional was conducted during May 2020 (n = 1100). association variables...
Tendinopathy pathogenesis is associated with inflammation. Regulatory T (Treg) cells contribute to early tissue repair through an anti-inflammatory action, the forkhead box P3 (FOXP3) transcription factor being essential for Treg function, and FC-receptor-like 3 (FCRL3) possibly negatively regulating function. FCRL3 –169T>C FOXP3 –2383C>T polymorphisms are located near elements that regulate respective genes expression, thus it was deemed relevant evaluate these as risk factors tendinopathy...
Abstract Background Anterior cruciate ligament (ACL) rupture is a common and severe knee injury in sports occurs mostly due to noncontact injuries. There an increasing amount of evidence associating ACL single nucleotide polymorphisms (SNPs), SNPs the collagen type I genes can change its expression tissue mechanical features. This study aimed investigate association between COL1A1 COL1A2 with sports-related tears. Methods A total 338 athletes from multiple modalities were analyzed: 146...
The role of vitamin D on bone microarchitecture and fragility is not clear.To investigate whether deficiency (25(OH)D <20 ng/mL) increases cortical loss the severity fractures.Cross-sectional study 287 elderly women with at least one prevalent low-impact fracture.Biochemistry, X-rays to identify vertebral fractures (VFs) confirm non-vertebral (NonVFs), high-resolution peripheral quantitative computed tomography (HR-pQCT) evaluate microstructure.Serum 25(OH)D levels were associated body mass...
Osteosarcoma is the most common primary bone tumor in children and young adults. The median survival of osteosarcoma patients has not significantly improved since 1990, despite administration different classes chemotherapy agents, such as methotrexate, cisplatin doxorubicin. Cancer stem cells (CSCs) are responsible for resistance to OCT4, SOX2 SSEA4 have been used identify CSCs osteosarcoma. Here, we low-passage patient-derived directly isolated from before after treatments evaluate effects...
OBJETIVO: Identificar a taxa de consolidação da fratura trocantérica instável submetida osteossíntese com haste femoral curta (PFN® - AO/ASIF), em pacientes operados entre novembro 1999 e março 2004. MÉTODOS: Foram analisados 45 idades 60 93 anos, portadores do fêmur, submetidos à PFN® curto, mediante redução indireta mesa tração auxílio radioscopia. As fraturas foram classificadas acordo classificação AO/OTA. A qualidade óssea foi avaliada através índice Singh, na rotina radiográfica...
Abstract Background High levels of the tumor necrosis factor alpha (TNF-α) induce apoptosis and pro-inflammatory effects for primary degeneration tendon development tendinopathy. The aim this study was to investigate association between TNF-α polymorphisms tendinopathy in athletes. Methods Two hundred seventy athletes (135 cases 135 controls) were included genotyped ( -1031T > C; -857 C T; -308G A ) using TaqMan validated assays. with evaluated by a multivariate logistic regression model,...
Fibrillin-1 (FBN1) is an extracellular matrix glycoprotein essential to the structural component of microfibrils and FBN1 gene polymorphisms can be associated with adolescent idiopathic scoliosis (AIS) susceptibility. This study aimed evaluate potential role rs12916536 polymorphism in AIS development or severity variation Cobb angle relation patient's characteristics.DNA from 563 subjects (185 patients 378 controls) were genotyped using a validated TaqMan allelic discrimination assay. A...
The key to preventing early knee osteoarthritis is meniscal preservation. main functions of the meniscus are impact absorption, mechanical load transmission, lubrication, joint stability, and proprioception. Radial lesions that extend capsule called complete radial tears. This type injury compromises 2 functions, which absorption distribution, equivalent, from a biomechanical perspective, total meniscectomy. In recent past, treatment choice for this was partial However, several studies have...
Background: Biomechanical assessment of meniscal repairs is essential for evaluating different suturing methods and techniques. The continuous suture technique a newer method repair that may have biomechanical differences compared with traditional Purpose: To evaluate the displacement, stiffness after cyclical loading, load to failure vertical inside-out versus in porcine medial meniscus. Study Design: Controlled laboratory study. Methods: A total 28 knees were acquired divided into 2 test...
In vitro-expanded bone marrow stromal cells (BMSCs) have long been proposed for the treatment of complex bone-related injuries because their inherent potential to differentiate into multiple skeletal cell types, modulate inflammatory responses, and support angiogenesis. Although a wide variety methods used expand BMSCs on large scale by using good manufacturing practice (GMP), little attention has paid whether expansion procedures indeed allow maintenance critical characteristics potency,...
Nonunion is a challenging condition in orthopaedics as its etiology not fully understood. Clinical interventions currently aim to stimulate both the biological and mechanical aspects of bone healing process by using autografts surgical fixation. However, recent observations showed that atrophic nonunion tissues contain putative osteoprogenitors, raising hypothesis reactivation could be explored achieve repair.Here we characterized stromal cells (NUSC) vitro, marrow (BMSC) osteoblasts...