A5067506104- SARS-CoV-2 and COVID-19 Research
- Central Venous Catheters and Hemodialysis
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Dialysis and Renal Disease Management
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Cardiac, Anesthesia and Surgical Outcomes
- Nutrition and Health in Aging
- Hematological disorders and diagnostics
- COVID-19 epidemiological studies
- Infectious Diseases and Tuberculosis
- Renal Diseases and Glomerulopathies
- Pneumonia and Respiratory Infections
- Muscle and Compartmental Disorders
- Vitamin D Research Studies
- Vascular Procedures and Complications
- Infective Endocarditis Diagnosis and Management
- Bacterial Infections and Vaccines
- Acute Kidney Injury Research
- COVID-19 and healthcare impacts
- COVID-19 and Mental Health
- Viral gastroenteritis research and epidemiology
- Ear Surgery and Otitis Media
- Vaccine Coverage and Hesitancy
Social Insurance Saitama Chuo Hospital
2019-2025
Saitama Medical University
2019-2025
Saitama University
2025
Matsuyama Red Cross Hospital
2014-2024
Hakodate Central General Hospital
2023
Weatherford College
2023
Unitika (Japan)
2023
Nagano University
2022
Kyushu University
2016-2020
Novartis (Japan)
2020
Although several coronavirus disease 2019 (COVID-19) vaccines initially showed high efficacy, there have been concerns because of waning immunity and the emergence variants with immune escape capacity.A test-negative design case-control study was conducted in 16 healthcare facilities Japan during Delta-dominant period (August-September 2021) Omicron-dominant (January-March 2022). Vaccine effectiveness (VE) against symptomatic severe acute respiratory syndrome 2 infection calculated for doses...
Abstract Current diagnostic testing for coronavirus disease 2019 (COVID-19) is based on detection of severe acute respiratory syndrome 2 (SARS-CoV-2) in nasopharyngeal swab samples by reverse transcription polymerase chain reaction (RT-PCR). However, this test associated with increased risks viral dissemination and environmental contamination shows relatively low sensitivity, attributable to technical deficiencies the sampling method. Given that COVID-19 transmitted via exhaled aerosols...
Abstract Background Volume overload is common and associated with high mortality in patients on peritoneal dialysis (PD). Traditional strategies including diuretics, water/salt restriction, icodextrin-based solutions cannot always fully correct this condition, necessitating novel alternative strategies. Recent studies confirmed the expression of sodium–glucose cotransporter 2 (SGLT2) human peritoneum. Experimental data suggest that SGLT2 inhibitors decrease glucose absorption from PD...
Abstract Background The relative burden of COVID‐19 has been less severe in Japan. One reason for this may be the uniquely strict restrictions imposed upon bars/restaurants. To assess if approach was appropriately targeting high‐risk individuals, we examined behavioral factors associated with SARS‐CoV‐2 infection community. Methods This multicenter case–control study involved individuals receiving testing June–August 2021. Behavioral exposures past 2 weeks were collected via questionnaire....
In this multicenter, prospective, test-negative, case-control study in Japan, the effectiveness of both BA.1-containing and BA.4/BA.5-containing bivalent coronavirus disease 2019 mRNA vaccines against symptomatic infection during BA.5-dominant period was high compared with no vaccination (65% 76%) moderate monovalent administered over half a year earlier (46% combined).
A previously healthy 58-year-old male initially presented to a healthcare facility with otorrhea in his left ear, accompanied by scab both the auricle and ear canal, lesion protruding from cavity oozing discharge (day 0). The following day, patient was transferred our fever altered consciousness. Imaging studies, including computed tomography magnetic resonance imaging, revealed soft tissue mass maxillary, ethmoid sphenoid sinuses, diffuse pus within subdural space over bilateral...
Background: Shared decision-making (SDM) is a key process in selecting renal replacement therapy (RRT). This study analyzed SDM perceptions, preferences, and patient- facility-level factors influencing among Japanese patients with chronic kidney disease (CKD) who selected RRT. Methods: We 475 adult CKD from 49 medical facilities. awareness recognition, preferences for timing frequency, discussion content, desired professional involvement were assessed. Patient- associated perceptions...
A previously healthy 58-year-old male initially presented to a healthcare facility with otorrhea in his left ear, accompanied by scab both the auricle and ear canal, lesion protruding from cavity oozing discharge (day 0). The following day, patient was transferred our fever altered consciousness. Imaging studies, including computed tomography magnetic resonance imaging, revealed soft tissue mass maxillary, ethmoid sphenoid sinuses, diffuse pus within subdural space over bilateral...
Treatment with cyclophosphamide and steroids for idiopathic membranous nephropathy (IMN) is effective in Caucasian patients, but the cumulative dosage exceeds 10 g includes steroid pulse therapy. Adverse effects difficulties repeating treatment are major limitations. We studied long-term outcomes of low-dose prednisolone therapy Japanese who were thought to have relatively benign IMN compared patients.This a prospective cohort study 103 consecutive patients nephrotic syndrome. Patients...
Background: Eldecalcitol (ELD) is an active vitamin D3 analog that widely used in Japan for the treatment of osteoporosis. The most common adverse drug reaction ELD hypercalcemia. However, few reports have focused on acute kidney injury (AKI) associated with ELD-induced hypercalcemia.Materials and methods: We retrospectively reviewed medical records at our hospital cases hypercalcemia-induced AKI between April 2013 February 2018. Among them, we patients who developed secondary to...
Abstract Background Capnocytophaga canimorsus is a gram-negative bacterium and an oral commensal in dogs cats, but occasionally causes serious infections humans. Septicemia one of the most fulminant forms, diagnosis C. infection often difficult mainly because its very slow growth. infective endocarditis (IE) rare poorly understood. Since quite few strains produce β-lactamase, antimicrobial susceptibility pivotal information for adequate treatment. We herein report case with IE results drug...
Repeated emergence of variants with immune escape capacity and waning immunity from vaccination are major concerns for COVID-19. We examined whether the surge in Omicron subvariant BA.5 cases was due to or through vaccine effectiveness (VE) evaluation.A test-negative case-control study conducted 16 clinics/hospitals during BA.1/BA.2-dominant BA.5-dominant periods. VE against symptomatic infection estimated after adjusting age, sex, comorbidity, occupation, testing frequency, prior infection,...
Some peritoneal dialysis (PD)-related peritonitis cases are thought to be caused by the pathogens in oral cavity; however, relationship between and hygiene habits is unclear. In this study, we retrospectively examined patients who agreed a questionnaire survey. Of 75 patients, 37 developed PD-related during observation period. Peritonitis-free survival was significantly higher spent more time on daily replaced their toothbrush frequently (P < 0.05). According multivariable analysis,...
Background Outflow obstruction, a common complication in patients with peritoneal dialysis (PD), usually results unnecessary catheter removal or replacement. This study describes modified simple method of anchoring PD on the anterior wall without using laparoscopic system (peritoneal anchor technique, PWAT). Methods We performed retrospective cohort consecutive insertions, and compared survival rate between traditional PWAT. The was used 54 cases PWAT 17 cases. primary endpoint occurrence...
Diagnosis of SARS-COV-2 infection (COVID-19) is currently based on detection the viral RNA in nasopharyngeal swab samples by reverse transcription polymerase chain reaction (RT-PCR). However, sampling via swabs frequently provokes sneezing or coughing, which results increased risk dissemination and environmental contamination. Furthermore, sensitivity associated with PCR tests s limited to 60%-70%, mainly attributable technical deficiency sampling. Given that disease transmitted exhaled...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant is considered responsible for worldwide surges in disease 2019 (COVID-19) cases 2021, with increased infectivity compared to the wild type (Wuhan-1). In a previous study, we identified temporal changes wild-type SARS-CoV-2 RNA load and detection rate EBC collected from COVID-19 patients. primary objective of this study was clarify Delta-variant rates patients, validate feasibility diagnosing COVID-19. secondary...
ABSTRACT A coma patient was diagnosed with tuberculous meningitis by the detection of ESAT-6-specific gamma interferon-secreting cells in patient's cerebrospinal fluid enzyme-linked immunospot assay prior to identification pathogen a culture fluid.
An 80-year-old man presented at our hospital with renal failure. He had been treated edoxaban, an oral direct factor Xa inhibitor, for deep vein thrombosis 10 months prior to admission. Although the pulses in his bilateral pedal arteries were palpable, cyanosis was present toes. Laboratory data indicated azotemia and eosinophilia. A skin biopsy confirmed a diagnosis of cholesterol crystal embolism (CCE). Because no invasive vascular procedure performed, we assumed that CCE related edoxaban....
Since the SARS-CoV-2 Omicron variant became dominant, assessing COVID-19 vaccine effectiveness (VE) against severe disease using hospitalization as an outcome more challenging due to incidental infections via admission screening and variable criteria, resulting in a wide range of estimates. To address this, World Health Organization (WHO) guidance recommends use outcomes that are specific pneumonia such oxygen mechanical ventilation. A case-control study was conducted 24 hospitals Japan for...
We present two cases of pulmonary aspergillosis in which calcium oxalate crystals the sputum proved to be a useful diagnostic clue. In case 1, Aspergillus hyphae was not identified; however, were present, and chronic necrotizing diagnosed. 2, detected fumigatus identified later. Thus, presence may an important indicator for A. infection.