A power and area efficient sensor interface consumes 6.4 mW from 1.2 V while occupying 5 mm × in 0.13 μm CMOS. The offers simultaneous access to 96 channels of broadband neural data acquired cortical microelectrodes as part a head-mounted wireless recording system, enabling basic neuroscience well neuroprosthetics research. Signals are conditioned with front-end achieving 2.2 μV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub>...

Objective. Motor neuroscience and brain–machine interface (BMI) design is based on examining how the brain controls voluntary movement, typically by recording neural activity behavior from animal models. Recording technologies used with these models have traditionally limited range of behaviors that can be studied, thus generality science engineering research. We aim to a freely-moving model using behavioral do not constrain movement. Approach. established rhesus monkey employing technology...

Many recent works take advantage of highly parallel analog in-situ computation in memristor crossbars to accelerate the many vector-matrix multiplication operations deep neural networks (DNNs). However, these accelerators have two significant shortcomings: The ADCs account for a large fraction chip power and area, adopt homogeneous design which every resource is provisioned worst case. By addressing both problems, new architecture, called Newton, moves closer achieving optimal energy per...

Neural recording systems that interface with implanted microelectrodes are used extensively in experimental neuroscience and neural engineering research. Interface electronics needed to amplify, filter, digitize signals from multichannel electrode arrays a critical bottleneck scaling such systems. This paper presents the design testing of an electronic architecture for intracortical drastically reduces size per channel by rapidly multiplexing many electrodes single circuit. The utilizes...

Physical devices used for switching have finite probabilities of failure. Circuits which make use redundancy to achieve resultant reliabilities greater than that their elements been proposed and analyzed the case intermittent failures. The present paper extends certain these results permanent failures elements, assuming reliability is known. It shown that, operating periods are short compared mean time failure a substantial increase in can be obtained by such redundancy.

Ovarian cancer is the fifth leading cause of death in women, part because limited knowledge about early stage disease. We develop a novel rat model ovarian and perform pilot study to examine harvested ovaries with complementary optical imaging modalities. Rats are exposed repeated daily dosing (20 days) 4-vinylcyclohexene diepoxide (VCD) failure (model for postmenopause), directly 7,12-dimethylbenz(a)anthracene (DMBA) abnormal proliferation neoplasia. Harvested examined coherence tomography...

This paper presents an in-depth noise and impedance characterization of two the most widely used microelectrode arrays (the Utah Electrode Array (UEA) Tucker-Davis Technologies (TDT) Microwire Array) provides quantitative analysis how properties change when implanted in rodent cortex. Custom low-noise circuits de-embedding methods were designed to acquire nV / √Hz power spectral densities from high-impedance electrodes. A total 80 electrodes across five rats measured under deep anesthesia,...

To measure pH of brain and other tissues in situ, a micro glass electrode capillary form was devised. The technique fabrication characteristics are described. Performance the cat is briefly discussed.

This report presents characterizations of in vivo neural recordings performed with a CMOS multichannel recording chip that uses rapid multiplexing directly at the electrodes, without any pre-amplification or buffering. Neural were taken from 16-channel microwire array implanted rodent cortex, comparison to gold-standard commercial bench-top system. We able record well-isolated threshold crossings 10 multiplexed electrodes and typical local field potential waveforms 16, strong agreement...

This paper provides a comprehensive review of Three-Independent-Gate Field-Effect Transistors (TIGFETs). In parallel to the focus on transistor scaling, an alternative approach push further performance computing systems consists in increasing functionalities basic transistors by means additional gate controls. TIGFETs belong this category devices and can achieve different modes operation according bias terminals. particular, these are capable (i) device-level polarity control, (ii) dynamic...

This manuscript presents a compact, low-noise signal conditioning chain for peripheral nerve recording from implanted microelectrodes. Chopping is used in combination with switched capacitor techniques to reduce circuit noise and area while achieving accurate passband gain corner frequencies. Time-windowed-integration sampling eliminate aliased introduced by the discrete time circuits ripple chopping. Gain transfer function accuracy are maintained taking advantage of open loop structures....

Field-Effect Transistors (FETs) with Three Independent Gates (TIG) can achieve different modes of operation according to the bias gate terminals. In particular, TIG FETs were recently shown capable (i) device-level polarity control, (ii) dynamic threshold modulation and (iii) subthreshold slope tuning down ultra-steep-slope operation. Experimentally demonstrated using both contemporary FinFETs emerging silicon nanowires channel technologies, TIGFETs unlock several design opportunities. this...

Implantable microelectrode arrays are key to gaining a better understanding of the brain and neural circuits, through large-scale stimulation recording activity. Sputtered iridium oxide film (SIROF) electrodes optimized for efficient charge delivery during stimulation, but their properties have not been well studied. Noise impedance fundamental that thoroughly characterized, they critical fidelity achievable with appropriately designed interface electronics. This report presents correlated...

This paper introduces a label-free, electronic biomolecular sensing platform for the detection and characterization of trace amounts biological toxins within complex background matrix. The mechanism signal transduction is electrostatic coupling molecule bond vibrations to charge transport across an insulated electrode-electrolyte interface. current resulting from interface flow has long been regarded as experimental artifact little interest in development traditional based biosensors like...

This paper reports on the effect of electrical performance related to magnetic seed layers used within planar power microinductors. These studies involve structural and characterisation Ni80Fe20 films electro-deposited non-magnetic (i.e. copper nickel respectively). Microelectronic mechanical test structures xray analysis have been characterise stress levels properties both layers. In addition, spiral micro-inductors, with patterned cores, fabricated in order confirm improvement from layers,...

This paper reports the development of processing methods and test structures for characterisation evaluation Parylene-C as an insulating structural layer material integration with planar micro-inductors. The process involves filling high aspect ratio gaps between copper Parylene subsequent chemical mechanical planarisation. A chip has been designed to characterise this results presented. Subsequently complete micro-inductors, magnetic cores, have fabricated demonstrate capability process.

This paper proposes high speed wireline communication over FDA-cleared implantable leads and connectors. It presents the electrical characterization of a clinically-used extension lead, discusses issues related to utilizing this type interconnect for high-speed communication. S-parameters TDR measurements are presented complete link constructed with commercial-off-the-shelf FPGA boards, which achieves low BER at 200 Mbps LVCMOS LVDS signaling. The study highlights new avenues research in...

Microelectrode arrays are one of the most important tools for advancing our knowledge biological neural systems. Thorough characterization microelectrode helps designers optimize interface circuits and systems as well microelectrodes themselves, which in turn enables a better understanding nervous Noise impedance electrode determining specifications electronics, but data largely lacking literature. This work presents engineering-oriented characterizations commonly used SIROF Utah Electrode...

In this article, we demonstrate an ultra-low energy eye gaze tracking system and distance ranger based on scleral coils developed specifically for smart contact lenses. The comprises of a set four (two transmitter two receiver) semi-circular, copper which are patterned flexible Kapton substrates conformally placed the scleras. thickness entire assembly is ~100 µm. A high- frequency amplitude modulated AC signal transmitted from coil in short bursts, induces EMF receiver that function...

An experimental 50-megacycle arithmetic unit has been built which performs a repetitive multiplication program and checks the results for errors. The uses pulse circuitry developed to perform digital operations at pulse-repetition rate. This paper describes system circuits required functions. These include full binary adder, phase-locked frequency divider provides 3.125-megacycle secondary timing source, reshaping retiming circuit using germanium diodes capacitive storage, high-speed shift...

Electronic interfaces to the nervous system are increasingly important for experimental neuroscience as well medical diagnostics and therapies. Existing neural limited, however, by use of passive recording stimulation devices that connected active electronics on separate physical platforms through large amounts wiring. This manuscript proposes a new approach integrate directly with using state-of-the-art silicon processing, assembly, packaging techniques. System concepts described fully...

This letter presents a low-noise integrated potentiostat for affinity-free molecular detection in applications personalized medicine. The sensing technique uses digital classifier to identify molecules through unique vibrational signatures. mechanism relies on coherent interference of electron wave functions at the interface between nanoscale working electrode and liquid electrolyte. Coherence is enabled by feedback, which reduces effective temperature electrons. described three-channel IC...

We develop an equivalent circuit model for charge transfer across a nanoscale electrochemical interface and apply it to tune the parameters so that tunneling electrons transduce information about vibronic structure of interface. Model predictions are broadly consistent with cyclic voltammograms acquired using custom, low-noise potentiostat on 50 nm diameter Pt(80%)–Ir(20%) electrode functionalized 10 gold nanoparticles immersed in phosphate buffer redox couple. Conductance–voltage sweeps 1...