A5004551532- Neurobiology and Insect Physiology Research
- Neural dynamics and brain function
- Insect and Arachnid Ecology and Behavior
- Photoreceptor and optogenetics research
- Insect and Pesticide Research
- Advanced Memory and Neural Computing
- Genetics and Neurodevelopmental Disorders
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
- Airway Management and Intubation Techniques
- Cell Adhesion Molecules Research
- Insect Utilization and Effects
- Neuroscience and Neuropharmacology Research
- Chemical Reactions and Isotopes
- Molecular Biology Techniques and Applications
- Vasculitis and related conditions
- Laser Applications in Dentistry and Medicine
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hematopoietic Stem Cell Transplantation
- Cephalopods and Marine Biology
- Liver Diseases and Immunity
- Abdominal vascular conditions and treatments
- Blood disorders and treatments
University of North Carolina at Chapel Hill
2022-2025
Kyoto University
2016-2023
Japan Society for the Promotion of Science
2022
Japanese Red Cross Nagoya Daiichi Hospital
2016
Bio-Medical Science (South Korea)
2015
Tohoku University
2014
RIKEN Center for Brain Science
2005
UCLA Medical Center
1998-1999
Auditory processing in the cerebral cortex is considered to begin with thalamocortical inputs layer 4 (L4) of primary auditory (A1). In this canonical model, A1 L4 initiate a hierarchical cascade, higher-order cortices receiving pre-processed information for slower integration complex sounds. Here, we identify alternative ascending pathways mice that bypass and directly reach multiple layers secondary (A2), indicating parallel activation these areas alongside sequential processing. We found...
Adequate responses to noxious stimuli causing tissue damages are essential for organismal survival. Class IV neurons in Drosophila larvae polymodal nociceptors responsible thermal, mechanical, and light sensation. Importantly, activation of provoked distinct avoidance behaviors, depending on the inputs. We found that thermal stimuli, but not blue stimulation, caused a unique pattern IV, which were composed pauses after high-frequency spike trains large Ca2+ rise dendrite (the transient)....
Nutrition in early life has profound effects on an organism, altering processes such as organogenesis. However, little is known about how specific nutrients affect neuronal development. Dendrites of class IV dendritic arborization neurons Drosophila larvae become more complex when the are reared a low-yeast diet compared to high-yeast diet. Our systematic search for key revealed that increase their terminal densities response combined deficiency vitamins, metal ions, and cholesterol. The...
Abstract Information flow in the sensory cortex has been described as a predominantly feedforward sequence with deep layers output structure. Although recurrent excitatory projections from layer 5 (L5) to superficial L2/3 have identified by anatomical and physiological studies, their functional impact on processing remains unclear. Here, we use layer-selective optogenetic manipulations primary auditory demonstrate that feedback inputs L5 suppress activity of regardless arousal level,...
In Drosophila larvae, Class IV sensory neurons respond to noxious thermal stimuli and provoke heat avoidance behavior. Previously, we showed that the activated displayed characteristic fluctuations of firing rates, which consisted repetitive high-frequency spike trains subsequent pause periods, proposed rate enhanced (Terada et al., 2016). Here, further substantiate this idea by showing periods frequency are regulated small conductance Ca2+-activated K+ (SK) channels, SK knockdown larvae...
Understanding computational principles in hierarchically organized sensory systems requires functional parcellation of brain structures and their precise targeting for manipulations. Although atlases are widely used to infer area locations the mouse neocortex, it has been unclear whether stereotaxic coordinates based on standardized morphology accurately represent domains individual animals. Here, we intrinsic signal imaging evaluate accuracy delineation atlas by mapping...
Appropriate modulation of escape behaviors in response to potentially damaging stimuli is essential for survival. Although nociceptive circuitry has been studied, it poorly understood how genetic contexts affect relevant responses. Using an unbiased genome-wide association analysis, we identified Ly6/α-neurotoxin family protein, Belly roll (Bero), which negatively regulates Drosophila behavior. We show that Bero expressed abdominal leucokinin-producing neurons (ABLK neurons) and bero...
Aging for 5 years, from 50 to 55 years of age, influenced the various markers in a normotensive group but similar correlation could not be seen hypertensive group. This suggests an impaired control physiological homeostasis subjects. An increase body mass index (BMI) is important predictor understanding pathogenesis hypertension, although mechanism uncertain. A reduction BMI may reduce risk high blood pressure.
Summary Information flow in the sensory cortex has been described as a predominantly feedforward sequence with deep layers output structure. Although recurrent excitatory projections from layer 5 (L5) to superficial L2/3 have identified by anatomical and physiological studies, their functional impact on processing remains unclear. Here, we use layer-selective optogenetic manipulations primary auditory demonstrate that feedback inputs L5 suppress activity of layers, contrary prediction...
Summary Understanding computational principles in hierarchically organized sensory systems requires functional parcellation of brain structures and their precise targeting for manipulations. Although atlases are widely used to infer area locations the mouse neocortex, it has been unclear whether stereotaxic coordinates based on standardized morphology accurately represent domains individual animals. Here, we intrinsic signal imaging evaluate accuracy delineation atlas by mapping...
63 We have shown that mononuclear cells (MNC) localize preferentially in fibronectin (FN)-rich areas rejecting rat cardiac allografts (Tx). The cellular form of FN (cFN), virtually absent native hearts, is primarily expressed by infiltrating macrophages and endothelial Tx. However, Tx rats rendered tolerant treatment with RIB-5/2, a nondepleting CD4 mAb, fail to express cFN. This study was designed test hypothesis the lack macrophage-derived may, fact, play functional role regulating IL-2...