A5047821211- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Peripheral Neuropathies and Disorders
- Immune Cell Function and Interaction
- Platelet Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Autoimmune Bullous Skin Diseases
- Chemokine receptors and signaling
- Protease and Inhibitor Mechanisms
- Acute Lymphoblastic Leukemia research
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Immunodeficiency and Autoimmune Disorders
- Hereditary Neurological Disorders
- Viral-associated cancers and disorders
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- CNS Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Calcium signaling and nucleotide metabolism
Chiba University Hospital
2016-2025
Chiba University
2012-2021
Dana-Farber Cancer Institute
2014-2018
Harvard University
2014-2018
Japanese Red Cross Narita Hospital
2006
Despite significant advances in the treatment of multiple myeloma (MM), most patients succumb to disease progression. One major immunosuppressive mechanisms that is believed play a role progression expansion regulatory T cells (Tregs). In this study, we demonstrate drive Treg and activation by secreting type 1 interferon (IFN). Blocking IFN α β receptor (IFNAR1) on Tregs significantly decreases both myeloma-associated function Using syngeneic transplantable murine models bone marrow (BM)...
Abstract Purpose: Tumor cell–platelet interactions contribute to tumor progression and metastasis in solid tumors. However, the role of platelets hematological malignancies is not clear. We investigated association platelet activation status with clinical stages multiple myeloma (MM) patients explored MM progression. Experimental Design: Platelets were obtained from healthy donors patients. examined by flow cytometry transmission electron microscopy. also observed enriched pathways that are...
ABSTRACT POEMS syndrome is a multisystemic disease associated with monoclonal plasma cell disorders. Although the presence of bone lesions included in diagnostic criteria, their precise manifestations remain unknown. Here, we retrospectively analyzed patients and evaluated clinical features. Clinical data lesion information by computed tomography (CT) imaging were obtained from 114 syndrome. Regardless sclerotic lesions, divided into two groups according to (lytic group: n = 17, 14.9%) or...
LR11, also known as SorLA or SORL1, is a type-I membrane protein from which large extracellular part, soluble LR11 (sLR11), released by proteolytic shedding on cleavage with disintegrin and metalloproteinase 17 (ADAM17). A mechanism presumed to have key role in the functions of but evidence for this has not yet been demonstrated. Tetraspanin CD9 recently shown regulate ADAM17-mediated tumor necrosis factor-α intercellular adhesion molecule-1 cell surface. Here, we investigated leukocytes....
Extramedullary blast crisis of chronic myelogenous leukemia (CML) is defined as the development extramedullary disease caused by infiltration blasts regardless proliferation in bone marrow. The onset newly diagnosed patients known to be extremely rare. Here, we present a case CML an initial presentation 17-year-old female presenting with pain left femur tumor. This was treated successfully dasatinib and allogeneic hematopoietic stem cell transplantation, achievement long-term remission.
Waldenström Macroglobulinemia (WM) is a low-grade B-cell lymphoma characterized by disease progression from IgM MGUS to asymptomatic and then symptomatic states. We profiled exosomes the peripheral blood of patients with WM at different stages (30 smoldering/asymptomatic WM, 44 samples 10 healthy controls) define their role as potential biomarkers progression. In this study, we showed that circulating miRNA content represent unique markers tumor its microenvironment. observed similar levels...
Hepatic sinusoidal obstructive syndrome (SOS), also known as hepatic veno-occlusive disease (VOD), is recognized one of the most important regimen-related toxicities experienced after hematopoietic stem cell transplantation (SCT). It a clinical characterized by painful hepatomegaly, jaundice, ascites, fluid retension, and weight gain [1]. Across 135 studies between 1979 2007, overall incidence was 13.7% in patients undergoing SCT [2], it usually occurs within first 3 weeks high-dose...
Abstract Clinically significant cytomegalovirus infection (csCMVi) is frequently observed after allogeneic hematopoietic stem cell transplantation (HSCT) and prophylaxis with letermovir commonly adopted. However, the clinical benefit of according to graft sources has not been sufficiently elucidated. We retrospectively analyzed 2194 recipients HSCT who were CMV-seropositive (236 1958 without against CMV). csCMVi was significantly less frequent in patients than those (23.7% vs 58.7% at 100...
We investigated the feasibility of using next-generation sequencing (NGS) technique molecular barcoding technology to detect MYD88 L265P mutation in unselected peripheral blood mononuclear cells (PBMCs) 52 patients with Waldenström's macroglobulinemia [1] and 21 IgM-monoclonal gammopathy undetermined significance (MGUS). The NGS successfully detected PBMCs at a sensitivity 0.02%, which was ×5 higher than that AS-PCR. All results between paired BM PB samples from 2 IgM MGUS 4 untreated WM...
Polyneuropathy, organomegaly, endocrinopathy, M‐protein, and skin changes (POEMS) syndrome is a rare plasma cell dyscrasia characterized by polyneuropathy, extravascular fluid overload, M protein, myriad of changes. The pathogenesis poorly understood, but monoclonal cells are λ‐restricted these immunoglobulin λ light chain variable (IGLV) region genes derived from only two germlines, either IGLV1‐44 or 1‐40 . Here we analyzed the clonal IGLV gene rearrangements genomic DNA samples bone...
Summary Recent large‐scale genetic studies have proposed a new classification of diffuse large B‐cell lymphoma (DLBCL), which is clinically and biologically heterogeneous. However, the methods were complicated to be introduced into clinical practice. Here we retrospectively evaluated mutational status copy number changes 144 genes in 177 Japanese patients with DLBCL, using targeted DNA sequencing. We developed simplified algorithm for classifying four subtypes—MYD88, NOTCH2, BCL2, SGK1—by...
POEMS syndrome is a rare monoclonal plasma cell disorder, with unique symptoms distinct from those of other neoplasms, including high serum VEGF levels. Because the prospective isolation clones has not yet been successful, their real nature remains unclear. Herein, we performed single-cell RNA-Seq BM cells patients and identified that had Ig λ light chain (IGL) sequences (IGLV1-36, -40, -44, -47) amino acid changes specific to syndrome. The proportions in were markedly smaller than multiple...