A5010477477- Cancer survivorship and care
- Global Cancer Incidence and Screening
- Smoking Behavior and Cessation
- Childhood Cancer Survivors' Quality of Life
- Cancer-related cognitive impairment studies
- Complementary and Alternative Medicine Studies
- Cancer Risks and Factors
- Cancer Treatment and Pharmacology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- COVID-19 and healthcare impacts
- Telemedicine and Telehealth Implementation
- Cell Adhesion Molecules Research
- Economic and Financial Impacts of Cancer
- Phytochemistry Medicinal Plant Applications
- Acute Myocardial Infarction Research
- Herbal Medicine Research Studies
- Cardiac Structural Anomalies and Repair
- Mast cells and histamine
- Monoclonal and Polyclonal Antibodies Research
- Cardiovascular Issues in Pregnancy
- Palliative Care and End-of-Life Issues
- Synthesis and biological activity
- Cardiac Imaging and Diagnostics
- Mobile Health and mHealth Applications
- Skin and Cellular Biology Research
University College Dublin
2012-2024
University of Oxford
1978-2023
Indiana University – Purdue University Indianapolis
2020
Health Sciences Centre
2017
University Child Development School
2017
St Vincent's Hospital
1982-2004
Children's Hospital of Michigan
1999
National Institutes of Health
1983-1999
National Institute of Dental and Craniofacial Research
1999
Beth Israel Deaconess Medical Center
1998
While some evidence exists that real-time remote symptom monitoring devices can decrease morbidity and prevent unplanned admissions in oncology patients, overall, these studies have significant methodological weaknesses. The electronic Symptom Management using the Advanced System (ASyMS) Remote Technology (eSMART) study is designed to specifically address weaknesses with an appropriately powered, repeated-measures, parallel-group stratified randomised controlled trial of patients.A total...
To evaluate effects of remote monitoring adjuvant chemotherapy related side via the Advanced Symptom Management System (ASyMS) on symptom burden, quality life, supportive care needs, anxiety, self-efficacy, and work limitations.Multicentre, repeated measures, parallel group, evaluator masked, stratified randomised controlled trial.Twelve cancer centres in Austria, Greece, Norway, Republic Ireland, UK.829 patients with non-metastatic breast cancer, colorectal Hodgkin's disease, or...
Abstract The vesiculo-vacuolar organelle (VVO) is a recently described found in the cytoplasm of endothelial cells that line tumor microvessels and normal venules. VVOs are grape-like clusters interconnecting uncoated vesicles vacuoles, bounded by trilaminar unit membranes, span entire thickness vascular endothelium, thereby providing potential transendothelial connection between lumen extravascular space. Macromolecular tracers preferentially cross hyperpermeable through VVOs. present...
The effects of ultraviolet radiation (UV) on the immune parameters human epidermis were studied. We determined both in vitro and vivo UV epidermal cell surface markers function allogeneic cell-lymphocyte reaction (ELR). Epidermal cells obtained immediately after exposure exhibited a dose-dependent decrease alloantigen-presenting ELR. This was not result number T6+ Dr+ Langerhans but due to their being less efficient at alloantigen presentation than equivalent numbers from unirradiated skin....
1. Baroreflex sensitivity was tested in three normal, borderline and one hypertensive subject before during mental arithmetic, the prolongation of pulse interval caused by a provoked rise blood pressure being used as measure baroreflex sensitivity. 2. significantly decreased arithmetic. 3. During arithmetic arterial fluctuated markedly. 4. These findings suggest that man, well animals, defence alerting reaction depresses control thus contributes to seen at this time.
Some oncology outpatients experience a higher number of and more severe symptoms during chemotherapy (CTX). However, little is known about whether this high risk phenotype persists over time. Latent transition analysis (LTA) was used to examine the probability that patients remained in same symptom class when assessed prior administration following their next dose CTX. For whose membership consistent, differences demographic clinical characteristics, quality life (QOL) were evaluated. The...
There has been an international shift in health care, which seen increasing focus and development of technological personalized at-home interventions that aim to improve outcomes patient-clinician communication. However, there is a notable lack empirical evidence describing the preparatory steps adapting implementing technology this kind across multiple countries clinical settings.This study aimed describe undertaken preparation multinational, multicenter randomized controlled trial (RCT)...
Aim To explore the experiences of a nursing team who implemented an international nurse-led clinical trial in practice and understand facilitators to their involvement. Background The role responsibilities nurse are advancing encompass research activity help inform evidence-based practice. However, several personal organisational challenges can inhibit nurses' capacity implement undertake within Methods Three focus groups were conducted with members (N = 18). Thematic analysis was employed,...
Effective symptom management is a critical component of cancer treatment. Computational tools that predict the course and severity these symptoms have potential to assist oncology clinicians personalize patient's treatment regimen more efficiently provide aggressive timely interventions. Three common inter-related in patients are depression, anxiety, sleep disturbance. In this paper, we elaborate on efficiency Support Vector Regression (SVR) Non-linear Canonical Correlation Analysis by...
Despite the benefits of quitting smoking for those who have cancer, including improved health outcomes and reduced therapeutic toxicities, it is unclear how many people are supported in quit attempts during this time. Variations availability provision cessation (SC) services reported, with little understanding challenges solutions. This co-designed study aimed to understand perspectives care professionals (HCPs) working oncology settings engage SC practices identify recommendations...
Abstract Ischaemic heart disease is rare in young women but expected to increase with increasing average age of child bearing. Diagnosis myocardial ischaemia this group complicated by limited data about maternal and fetal safety the standard diagnostic tests routinely used other patients. Management these patients remains difficult, as many treatments, such beta‐blockers angiotensin converting enzyme inhibitors are pregnancy category C or D, there little experience newer treatments coronary...