A5043894069- Extracellular vesicles in disease
- Heat shock proteins research
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Virus-based gene therapy research
- thermodynamics and calorimetric analyses
- Advanced biosensing and bioanalysis techniques
- Wound Healing and Treatments
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Connexins and lens biology
- RNA Interference and Gene Delivery
- Endoplasmic Reticulum Stress and Disease
- Viral Infections and Vectors
- Neuroblastoma Research and Treatments
- COVID-19 Clinical Research Studies
- Protease and Inhibitor Mechanisms
- Diabetes Management and Research
- Phase Equilibria and Thermodynamics
- Pancreatic function and diabetes
- Cutaneous Melanoma Detection and Management
- Neurogenesis and neuroplasticity mechanisms
- Liver Disease Diagnosis and Treatment
- Dengue and Mosquito Control Research
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
2023-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Istituto di Biomedicina e di Immunologia Molecolare Alberto Monroy
2016-2022
National Research Council
2022
University of Palermo
2014
Lung cancer represents the leading cause of cancer-related mortality worldwide, with around 1.8 million deaths in 2020. For this reason, there is an enormous interest finding early diagnostic tools and novel therapeutic approaches, one which extracellular vesicles (EVs). EVs are nanoscale membranous particles that can carry proteins, lipids, nucleic acids (DNA RNA), mediating various biological processes, especially cell–cell communication. As such, they represent interesting biomarker for...
Background/Objectives: Type 1 diabetes (T1D) is a chronic autoimmune condition characterized by the destruction of pancreatic β-cells, leading to insulin deficiency. Current therapies, such as islet transplantation, face significant challenges, including limited donor availability and need for lifelong immunosuppression. Encapsulation technologies offer promising alternative, providing immune protection maintaining β-cell viability. In this study, we propose an encapsulation device featuring...
Mouse mesoangioblasts are vessel‐associated progenitor stem cells endowed with the ability of multipotent mesoderm differentiation. Therefore, they represent a promising tool in regeneration injured tissues. Several studies have demonstrated that homing into blood and tissues mainly controlled by cytokines/chemokines other inflammatory factors. However, little is known about molecular mechanisms regulating their to traverse extracellular matrix (ECM). Here, we demonstrate membrane vesicles...
Since its identification, HCV has been considered one of the main causes hepatitis and liver cancer. Currently, molecular mechanisms HCC development induced by infection have not sufficiently clarified. The recent discovery novel treatments that inhibit replication gave rise to new questions concerning mechanisms. In particular, eradication mediated direct-acting antiviral (DAAs) drugs does exclude possibility de novo development; this finding opened more on interplay between cells virus....
Objective. To investigate the role of shed microvesicles (MV) derived from cerebrospinal fluid (CSF) as possible biomarkers in multiple sclerosis (MS) and other neurological disturbances. Background. Recent studies suggest that any kind cells, secrete extracellular MV a mean cell-to-cell communication. Lately, it has been suggested microglial vesicles, isolated by CSF could be for inflammation diseases. Design/Methods. Patients were recruited at Neurological Department University Palermo....
Pancreatic cancer (PCa) is the fifth leading cause of mortality. Recently, our group and others have demonstrated oncolytic activity Zika virus (ZIKV) against glioblastoma. The peculiar features this offer opportunity to use an agent already tested in vivo through natural transmission, with minimal effects on adults, specifically target a tumor such as This remarkable specificity prompted us explore potential ZIKV action other types. In particular, we focused subgroup pancreatic tumors...