The polysaccharides found in Caulerpa lentillifera (sea grape algae) are potentially an important bioactive resource. This study makes use of RSM (response surface methodology) to determine the optimal conditions for extraction valuable SGP polysaccharides). findings indicated that a water/raw material ratio 10:1 mL/g, temperature 90 °C, and time 45 min would maximize yield, with experimentation achieving yield 21.576 %. After undergoing purification through DEAE-52 cellulose Sephacryl S-100...

Five compounds including a new bisbibenzyl named dendropachol (1) and four known (2–5) comprising 4,5-dihydroxy-2,3-dimethoxy-9,10-dihydrophenanthrene (2), gigantol (3), moscatilin (4) 4,5,4′-trihydroxy-3,3′-dimethoxybibenzyl (5) were isolated from methanolic extract of Dendrobium pachyglossum (Orchidaceae). The chemical structures the characterized by spectroscopic methods. Dendropachol was investigated for its protective effects on hydrogen peroxide (H2O2)-induced oxidative stress in HaCaT...

The present study aimed to investigate the impact of Clostridium butyricum probiotic feed additive on sow and piglet performances, together with alterations in lipidomic metabolomic profiles milk. Sixty-four Landrace × Yorkshire crossbred sows 794 piglets were included. Sows divided into two groups; i.e., (i) conventional gestation diet (control; n = 35) (ii) added 10 g/sow/day C. spores (treatment; 29) from one week before estimated farrowing day until weaning (29.6 ± 4.8 days)....

ABSTRACT The present study aimed to investigate the effects of probiotic Bacillus licheniformis DSMZ 28710 supplementation on sow performance, Preweaning piglet and biochemical profiles colostrum milk. Sixty‐eight crossbred sows (Landrace Yorkshire) were allocated either a standard lactation diet (Control; n = 35) or Control supplemented with 10 g/sow/day B. (Treatment; 33), from day 109 gestation until 21 lactation. Sow as well incidence diarrhea, recorded. Moreover, investigated changes in...

Euglena gracilis, an algae-derived source of β-glucan, exhibits prebiotic activity that enhances colostrum quality and improves growth, though the underlying mechanisms remain unclear. This study investigates effects E. gracilis supplementation during late gestation lactation on sow milk biomolecular profiles. Sixty-one crossbred sows (Landrace × Yorkshire) were assigned to a standard diet (CON; n = 30) or CON supplemented with 1 g/sow/day (TRT; 31) from day 85 until 21 lactation. Sow...

A MeOH extract from the whole plant Dendrobium venustum exhibited significant antimalarial and anti-herpetic activities. Bioassay-guided isolation of resulted in seven known phenolic compounds. Densiflorol B (3) phoyunnanin E (6) showed strongest activity a high selectivity index, whereas gigantol (2), batatasin III (5) C (7) moderate activity. Compounds 2 5 also weak against Herpes simplex virus. This study is first report on chemical biological activities D. venustum.

Phytochemical investigation of the whole plant Dendrobium scabrilingue resulted in isolation two new compounds namely dendroscabrols A (1) and B (2), along with eight known (3–10). The structures these were determined by NMR HR-ESI-MS experiments. All isolates evaluated for their α-glucosidase inhibitory effect. Dendroscabrol (2) RF-3192C (10) showed most potent activity. (1), gigantol (5), coelonin (7) lusianthridin (9) also exhibited strong activity as compared positive control acarbose.

Carboxyl groups along poly(acrylic acid) (PAA) brushes attached to the surface of a gold-coated substrate served as precursor moieties for covalent immobilization amino-functionalized biotin or bovine serum albumin (BSA) form sensing probe streptavidin (SA) anti-BSA detection, respectively. Surface-grafted PAA were obtained by acid hydrolysis poly(tert-butyl acrylate) brushes, formerly prepared surface-initiated atom transfer radical polymerization tert-butyl acrylate. As determined plasmon...

Dendrobium bibenzyls and phenanthrenes such as chrysotoxine, cypripedin, gigantol moscatilin have been reported to show promising inhibitory effects on lung cancer growth metastasis in ex vivo human cell line models, suggesting their potential for clinical application patients with cancer. However, it remains be determined whether these therapeutic can also seen primary cells and/or vivo. In this study, we comparatively investigated the immune modulatory of phenanthrenes, including a novel...

Abstract The objective of this study was to investigate the impact lactation stage and parity number on fatty acid non-volatile polar metabolite profiles in sow colostrum milk using a metabolomics approach. A total 63 colostrum, transient mature were collected from primiparous multiparous Landrace × Yorkshire crossbred sows. Macrochemical, compositions samples analyzed infrared spectrometry, gas chromatography coupled with mass-spectrometry proton nuclear magnetic resonance spectroscopy,...

Two new dihydrophenanthrenes, dendroinfundin A (1) and B (2) were isolated from the whole plant of Dendrobium infundibulum, together with 7 known compounds (3-9). The structures (1 2) established on basis their spectroscopic data. All isolates evaluated for α-glucosidase pancreatic lipase inhibitory activities. Batatasin III (5) dendrosinen (9) showed strong activity. Dendrosinen also exhibited appreciable effect.

Two new compounds, dihydrodengibsinin (1) and dendrogibsol (2), were isolated from the whole plant of Dendrobium gibsonii, together with seven known compounds (3–9). The structures elucidated by their spectroscopic data. All these isolates evaluated for α-glucosidase inhibitory activities. Dendrogibsol (2) lusianthridin (7) showed strong activity when compared acarbose. An enzyme kinetic study revealed that is a noncompetitive inhibitor α-glucosidase.

A phytochemical investigation on the whole plants of Aerides multiflora revealed presence three new biphenanthrene derivatives named aerimultins A–C (1–3) and a natural phenylpropanoid ester dihydrosinapyl dihydroferulate (4), together with six known compounds (5–10). The structures were elucidated by analysis their spectroscopic data. All isolates evaluated for α-glucosidase inhibitory activity. Aerimultin C (3) showed most potent other compounds, except compound 4, also exhibited stronger...

A methanolic extract from the dried root of Dendrobium christyanum Rchb.f. (Orchidaceae) exhibited α-glucosidase inhibitory activity and glucose uptake stimulatory effect. Chromatographic separation led to isolation 13 phenolic compounds (1-13). Their structures were determined by spectroscopic analysis. The isolates then evaluated for in vitro activities. Methyl haematommate (1), methyl 2,4-dihydroxy-3,6-dimethylbenzoate (3), n-docosyl 4-hydroxy- trans-cinnamate (4), coniferyl aldehyde (6),...

Oxidative stress is a significant factor in the development of age-related macular degeneration (AMD), which results from cell damage, dysfunction, and death retinal pigmented epithelium (RPE). The use natural compounds with antioxidant properties to protect RPE cells oxidative has been explored Dendrobium, genus orchid plants belonging family Orchidaceae. Two new seven known MeOH extract whole plant Dendrobium virgineum were successfully isolated structurally characterized. Out all...

It is well recognized that the aging process a critical step in winemaking because it induces substantial chemical changes linked to organoleptic properties and stability of finished wines. Therefore, this study aimed investigate influence different types, utilization times, volumes barrels on metabolite profile red wines, produced from Thai-grown Shiraz grapes, using non-targeted proton nuclear magnetic resonance (1H-NMR) metabolomics approach. As result, 37 non-volatile polar metabolites...

The objectives of this study were to characterize and compare non-volatile polar metabolite profiles bovine colostrum, collected within 1 h at 72 after parturition, from crossbred Holstein cows raised in northeastern Thailand. colostrum serum was characterized compared using a non-targeted proton nuclear magnetic resonance (1H-NMR) technique combined with chemometric analysis. Results demonstrated that the main effect post-parturition time provided significant impact on physical properties...

From the whole plant of Dendrobium senile, a new phenanthrene namely 2,5,7-trihydroxy-4-methoxyphenanthrene (1) was isolated, together with seven known compounds including moscatin (2), 2,5-dihydroxy-4,9-dimethoxyphenanthrene (3), moscatilin (4), aloifol I (5), 4,4',8,8'-tetramethoxy[1,1'-biphenanthrene]-2,2',7,7'-tetrol (6), 2,2',7,7'-tetrahydroxy-4,4'-dimethoxy-1,1'-biphenanthrene (7) and bleformin G (8). The structure compound elucidated by analysis its spectroscopic data. Moscatin (2)...

Two new 2-arylbenzofurans, namely 13-O-methyllakoochin B (1) and artogomezianin (2), were isolated from the root bark of Artocarpus gomezianus, along with six known compounds (3-8). The structures determined by spectroscopic chemical methods. All isolates evaluated for their α-glucosidase inhibitory activity. Artogomezianin (2) lakoochin A (3) exhibited strong activity IC50 values 18.25 26.19 µM, respectively, as compared positive control acarbose.

Objective. Previous studies suggested a role for the death decoy receptor 3 (DcR3) in pathogenesis of adult systemic lupus erythematosus (SLE). We investigated DcR3 juvenile-onset SLE, to identify polymorphisms that might alter function this protein. Methods. was measured serum 61 patients with juvenile SLE. The coding region gene sequenced 100 and 103 together 500 healthy controls. Results. elevated active SLE disease (440.8 ± 169.1 pg/ml), compared inactive (122.6 28.05 pg/ml; p = 0.0014)...

The phytochemical investigation of Huberantha jenkinsii resulted in the isolation two new and five known compounds. compounds were characterized as undescribed 8-oxoprotoberberine alkaloids named huberanthines A B, whereas identified allantoin, oxylopinine, N-trans-feruloyl tyramine, N-trans-p-coumaroyl mangiferin. structure determination was accomplished by spectroscopic methods. To evaluate therapeutic potential diabetes Parkinson’s disease, isolates subjected to assays for their...

The aims of this study were to characterize and compare non-volatile polar metabolite profiles organic conventional liquid milk products using a non-targeted proton nuclear magnetic resonance ( 1 H-NMR) metabolomics approach. Pasteurized plain-liquid from 10 different brands available in Thai marketplace analyzed for their major chemical compositions H-NMR derived metabolome data. Results demonstrated no specific trend differentiation between samples based on pH, fat, protein, lactose,...

The polysaccharides found in sea grape algae (Caulerpa lentillifera) are potentially an important bioactive resource. This study makes use of RSM (response surface methodology) to determine the optimal conditions for extraction valuable SGP (sea polysaccharides). findings indicated that a water/raw material ratio 10:1 mL/g, temperature 90°C, and time 45 minutes would maximize yield, with experimentation achieving yield 21.576%. Purification takes place after extraction, using DEAE-52...