A5000160709- Insect Resistance and Genetics
- Cancer Treatment and Pharmacology
- Viral Infectious Diseases and Gene Expression in Insects
- Estrogen and related hormone effects
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- Autism Spectrum Disorder Research
- Sports Performance and Training
- Lung Cancer Treatments and Mutations
- Advanced Breast Cancer Therapies
- Muscle metabolism and nutrition
- Reproductive tract infections research
- Cancer Genomics and Diagnostics
- Family and Disability Support Research
- Exercise and Physiological Responses
- Empathy and Medical Education
- Insect Pest Control Strategies
- Chronic Myeloid Leukemia Treatments
- Insect symbiosis and bacterial influences
- Insect and Pesticide Research
- Hemophilia Treatment and Research
- Cardiovascular and exercise physiology
- Insect-Plant Interactions and Control
- Cancer Risks and Factors
Mayo Clinic
2021-2024
AstraZeneca (United Kingdom)
2002-2023
A.T. Still University
2007-2022
Mayo Clinic in Arizona
2020
AstraZeneca (Brazil)
2012
Virginia Tech
2011
Indiana University – Purdue University Indianapolis
2008-2011
University of Miami
2010
Columbia University
2009
Riley Hospital for Children
2008
ABSTRACT Staphylococcus aureus is a major community and nosocomial pathogen. Its ability to withstand multiple stress conditions quickly develop resistance antibiotics complicates the control of staphylococcal infections. Adaptation lower temperatures key for survival bacterial species outside host. Branched-chain α-keto acid dehydrogenase (BKD) an enzyme complex that catalyzes early stages branched-chain fatty (BCFA) production. In this study, BKD was inactivated, resulting in reduced...
This study was undertaken to examine the relationship between energy expenditure and work rate on a bicycle ergometer in five sprinters distance runners who differed maximal oxygen uptake (VO2max) type of training. Each subject performed at rates 30, 60, 90, 120, 150 watts (W). The most accurately described by quadratic curve for both groups: sprinters, (kJ) = 11.57 + 0.1812 (W) 0.00046 (W)2; runners, 11.74 0.1386 0.00060 (W)2. Delta efficiency (delta accomplished divided delta expended X...
<h3>Background</h3> Hyperventilation has been shown to be associated with cerebral vasoconstriction and increased risk of infarction. Our aim was determine whether spontaneous reduction in end-tidal CO<sub>2</sub> (EtCO<sub>2</sub>) an brain tissue hypoxia (BTH). <h3>Method</h3> We studied 21 consecutive patients (mean age 50±16 years; 15 women) undergoing continuous monitoring for oxygenation (PbtO<sub>2</sub>), intracranial pressure (ICP), perfusion (CPP) EtCO<sub>2</sub>; mean values were...
Transient fluctuations in immune function after heavy exercise have been linked to an increased incidence of infection athletes. Several parameters immunity, including salivary immunoglobulin A (IgA), are affected by the laboratory setting. However, few observations made during true competition. We tested hypothesis that IgA levels will be decreased a collegiate rugby game. Saliva samples obtained from 16 men's college players before and 80-minute regulation game were analyzed for total...
3520 Background: Agents that specifically inhibit the invasive phenotype of cancers are urgently required. AZD0530 is a potent, orally administered inhibitor Src has been shown preclinically to prevent phosphorylation downstream mediators motility and invasion, paxillin (Pax) focal adhesion kinase (FAK), with inhibition metastasis in vivo. Although activation associated poor prognosis, activity human never demonstrated. Methods: Patients cancer received dose cohorts 50 mg 250 daily this...
As a prelude to combination studies aimed at resistance reversal, this dose-escalation/dose-expansion study investigated the selective Src kinase inhibitor saracatinib (AZD0530) in with carboplatin and/or paclitaxel. Patients advanced solid tumours received once-daily oral tablets either AUC 5 every 3 weeks (q3w), paclitaxel 175 mg m−2 q3w, 80 1 week (q1w), or plus q3w. The primary endpoint was safety/tolerability. A total of 116 patients 125 (N=20), (N=44), 225 (N=40), 250 (N=9), 300 (N=3)....
Unbalanced 3-factor design with repeated measures on 1 factor.To determine the effect of manual treatment (MT) cytokine and pain sensations in those without low back (LBP).Evidence suggests that MT reduces LBP but by unknown mechanisms. Certain cytokines have been elevated patients may be affected MT.Participants aged 20-60 years chronic or were recruited randomly assigned to MT, sham ultrasound treatment, no groups. Venous blood samples collected levels assessed at baseline, hour later, 24...
Anastrozole is an orally active, non-steroidal aromatase inhibitor which appears effective as neoadjuvant treatment of breast cancer. Histological changes have been evaluated in biopsies from large, oestrogen-receptor rich, operable tumours postmenopausal women following 12 weeks anastrozole (1 mg (n=12) or 10 (n=11)). Of the 23 patients, 18 had a clinical response treatment. Compared with pre-treatment anastrozole-treated specimens displayed decreased cellularity and/or increased fibrosis...
Ecologists have been using immunological assays to analyze the contents of arthropod stomachs for more than four decades. The assay choice today is microplate ELISA : it sensitive and, once prefected, relatively foolproof. However, requires an expensive spectrophotometric reader interpret and a statistical decision determine negativity positivity. Our immunodot assay, monoclonal antibody Heliothis zea (Boddie) arylphorin, species- instar-specific, comparable in sensitivity, takes less three...
Background : Small-group case presentation exercises (CPs) were created to increase course relevance for medical students taking Medical Microbiology (MM) and Infectious Diseases (ID) Methods Each student received a unique paper had 10 minutes review patient history, physical exam data, laboratory data. Students then three orally present their defend why they ruled in or out each of the answer choices provided, followed by an additional questions. Results Exam scores differed significantly...
The purpose of this investigation was to determine if a new proposed arm ergometer protocol advantageous in eliciting higher peak oxygen uptake (peak VO2) when compared with two protocols currently referred the literature. Ten male subjects were tested on three different exercise protocols; discontinuous test (DT), continuous (CT) and jump-max (JMT). CT began at work rate 33 watts (W) (40 rpm) power output (PO) being increased 16 W every 3 minutes. DT without resistance flywheel (50 by 25...
The effect of anastrozole on peripheral and tumour aromatase activity oestrogen levels in postmenopausal patients with receptor-rich breast tumours was investigated. Twenty-six were randomly allocated to treatment 1 mg (n=13) or 10 (n=13), once daily. Before after 12 weeks' treatment, infused 3H-Δ4 androstenedione (20 MBq) 14C-oestrone (E1) (1 for 18 h. Oestrogens purified from excised plasma samples taken each infusion. Peripheral E1 uptake calculated 3H 14C fractions plasma. Endogenous...
Vertebrate antisera have been used for phylogenetic analysis >85 yr by raising them against molecules from one taxon and reacting with homologous other taxa in the groups under consideration. The reactions are evaluated quantitatively to estimate immunological distances between taxa. strength of these reflects summation interactions individual antibodies making up antiserum antigenic determinants they recognize on molecule. availability monoclonal makes possible a new approach because that...