A5055377897- Bladder and Urothelial Cancer Treatments
- Diet, Metabolism, and Disease
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Chronic Myeloid Leukemia Treatments
- Chromatography in Natural Products
- Phytochemistry and biological activity of medicinal plants
- DNA Repair Mechanisms
- Ion Transport and Channel Regulation
- Advanced Biosensing Techniques and Applications
- Ginseng Biological Effects and Applications
- Phytochemistry and Bioactive Compounds
- FOXO transcription factor regulation
- Acute Kidney Injury Research
- ATP Synthase and ATPases Research
- Morinda citrifolia extract uses
- Nanoparticle-Based Drug Delivery
- Circular RNAs in diseases
- Neuroblastoma Research and Treatments
- Electrolyte and hormonal disorders
- Vibrio bacteria research studies
- Sarcoma Diagnosis and Treatment
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and Biological Activities
- Urinary and Genital Oncology Studies
Ministry of Education of the People's Republic of China
2017-2024
Northwest University
2017-2024
Imperial College London
2017
Ontario Institute for Cancer Research
2013
Princess Margaret Cancer Centre
2013
University of Toronto
2013
CRUK/MRC Oxford Institute for Radiation Oncology
2013
University of Bradford
2013
University of Oxford
2013
University of Leeds
2011
Previous studies had showed that Apelin 13 could protect against apoptosis induced by ischemic/reperfusion (I/R). However, the mechanisms whereby protected brain I/R remained to be elucidated. The present study was designed determine whether provided protection through AMPK/GSK-3β/Nrf2 pathway.In vivo, model and given intracerebroventricularly 15 min before reperfusion. neurobehavioral scores, infarction volumes, some cytokines in were measured. For vitro study, PC12 cells used. To clarify...
Saponin from Aralia taibaiensis (sAT) showed excellent antioxidative effects in several models; however, its on brain cells were unknown to us. The present study was designed evaluate the protective of sAT ischemia/reperfusion- (I/R-) induced injury and clarify mechanisms. In vitro, HT22 pretreated with then subjected I/R. Apoptosis rate, mitochondrial function, antioxidant proteins measured. To mechanisms, siRNA used. vivo, through intragastric administration for 7 days I/R model induced....
Radiotherapy is a major treatment modality used to treat muscle-invasive bladder cancer, with patient outcomes similar surgery. However, radioresistance significant factor in failure. Cell-free extracts of tumors are defective nonhomologous end-joining (NHEJ), and this phenotype may be clinically by combining radiotherapy radiosensitizing drug that targets homologous recombination, thereby sparing normal tissues intact NHEJ. The response the recombination protein RAD51 radiation inhibited...
Gentiopicroside isolated from gentiana macrophylla Pall. belongs to iridoid glycosides. This study aimed evaluate the protective effect of gentiopicroside against ethanol‐induced gastric mucosal injury in mice. Mice were proactively administrated with by intragastric administration once a day for 3 consecutive days. On 3rd day, ulcer mice was induced 70% ethanol after last administration. The stomach tissues submitted evaluation severity alterations. orally ameliorated Oral significantly...
Senna and its main components sennosides are well-known effective laxative drugs used in the treatment of intestinal constipation world. Their potential side effects have attracted more attention clinics but little scientific justification. In this study, senna extract (SE), (SS), sennoside A (SA) were prepared to generate diarrhea rats. The rats investigated with behaviors, clinical signs, organ index, pathological examination, gene expression on multiple aquaporins (Aqps) including Aqp1,...
Islet β cell mass reduction induced by glucose fluctuation is crucial for the development and progression of T2DM. Chikusetsu saponin IVa (CHS) had protective effects against DM related injuries. Here we aimed to investigate role CHS in injuries its possible mechanism involved. Isolated rat islets, βTC3 cells T2DM mice were used this study. The results showed that restored secretion activity, promoted survival increasing proliferation decreasing apoptosis which intermittent high (IHG). In...
Senna and rhubarb are often used as routine laxatives, but there differences in mechanism of action potential side effects. Here, we studied metabolites senna anthraquinones (SAQ), (RAQ) their chemical marker, sennoside A (SA), a rat diarrhea model. In vitro biotransformation experiments, SAQ, RAQ SA were incubated with fecal flora solution the produced analyzed using HPLC. vivo studies, same compounds investigated for purgation induction, measurement histopathology Aqps gene expression six...
The XPC gene is involved in repair of bulky DNA adducts formed by carcinogenic metabolites and oxidative damage, both known bladder cancer risk factors. Single nucleotide polymorphisms (SNPs) have been associated with increased risk. Recently, rarer genetic variants identified but it difficult to ascertain which are functional importance. During a mutation screen from 33 tumour samples matched blood samples, we five novel the patients’ germ line DNA. In case–control study 771 cases 800...
Pseudomonas aeruginosa is an important opportunistic pathogen, and the emergence of drug resistance greatly increased difficulty treating its infection. Cell density-dependent quorum sensing (QS) system not only regulates virulence but also associates with P. aeruginosa. Screening for agents targeting QS to inhibit bacterial pathogenicity considered a promising strategy combat In present study, sennoside A was found be able expression at subinhibitory concentrations. The QS-regulated...
Restoration of blood supply is a desired goal for the treatment acute ischemic stroke. However, restoration often leads to cerebral ischemia-reperfusion injury (CIR/I), which greatly increases risk non-neural organ damage. In particular, kidney might be one most common complications.
Abstract Background XPC is involved in the nucleotide excision repair of DNA damaged by carcinogens known to cause bladder cancer. Individuals homozygous for variant allele c.1496C > T (p.Ala499Val) were shown a large pooled analysis have an increased cancer risk, and we found two 3'UTR variants, *611T A c.*618A G, be strong linkage disequilibrium with c.1496T. Here determined if these variants can affect mRNA stability assessed impact all three on protein expression. Methods In vitro...
<div>Abstract<p>Radiotherapy is a major treatment modality used to treat muscle-invasive bladder cancer, with patient outcomes similar surgery. However, radioresistance significant factor in failure. Cell-free extracts of tumors are defective nonhomologous end-joining (NHEJ), and this phenotype may be clinically by combining radiotherapy radiosensitizing drug that targets homologous recombination, thereby sparing normal tissues intact NHEJ. The response the recombination protein...
<div>Abstract<p>Radiotherapy is a major treatment modality used to treat muscle-invasive bladder cancer, with patient outcomes similar surgery. However, radioresistance significant factor in failure. Cell-free extracts of tumors are defective nonhomologous end-joining (NHEJ), and this phenotype may be clinically by combining radiotherapy radiosensitizing drug that targets homologous recombination, thereby sparing normal tissues intact NHEJ. The response the recombination protein...