A5066422791- Flavonoids in Medical Research
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Phytochemicals and Antioxidant Activities
- Medicinal Plants and Neuroprotection
- Ginkgo biloba and Cashew Applications
- Medicinal Plants and Bioactive Compounds
- Chemical synthesis and alkaloids
- Dementia and Cognitive Impairment Research
- 14-3-3 protein interactions
- Bioactive natural compounds
- Phytochemistry Medicinal Plant Applications
- Saffron Plant Research Studies
- Phytochemistry and Biological Activities
- Neuroscience and Neuropharmacology Research
- Tea Polyphenols and Effects
- Chromatography in Natural Products
- Neurological Disease Mechanisms and Treatments
- Phytochemicals and Medicinal Plants
- Water Resource Management and Quality
- PARP inhibition in cancer therapy
- Sulfur Compounds in Biology
- Bioactive Compounds and Antitumor Agents
Centro Uruguayo de Imagenología Molecular
2020-2025
Instituto de Investigaciones Biológicas Clemente Estable
2009-2024
University of Chile
2004
Natural products play a crucial role in drug discovery, primarily due to their structural complexity. The prenylated flavanone glabranin ((S)-5,7-dihydroxy-8-(3-methylbut-2-en-1-yl)-2-phenylchroman-4-one), isolated from the Dalea elegans plant species, has demonstrated neuroprotective effects, attributed its inhibition of GSK-3β, as per our previous silico studies. Given enzyme's diverse functions and potential target for neurodegenerative diseases, group synthesized evaluated an 11C-labeled...
Quercetin shows structural features that have been related to the antioxidant potency of flavonoids and also neuroprotection in different models oxidative death. Because only a few studies focused on flavonoid requirements for neuroprotection, this work evaluated protective capacity 13 flavones structurally quercetin, isolated from Kenyan plants, rescue primary cerebellar granule neurons death induced by treatment with 24 h hydrogen peroxide (150 μM). Each flavone (0−100 μM) was applied...
The role of monoamine oxidase A (MAO-A) in the aggressiveness prostate cancer (PCa) has been established recent years. molecular imaging MAO-A expression could offer a noninvasive tool for visualization and quantification highly aggressive PCa. This study reports synthesis preclinical evaluation 11C- 18F-labeled inhibitors as positron emission tomography (PET) tracers proof-of-concept studies animal models Good manufacturing practice production quality control these radiotracers using an...
Some of the beneficial effects Mediterranean diet on human pathologies have been attributed to red wine polyphenols. It has postulated that antioxidant activity latter would be also responsible for cytoprotective capacity reported in a few papers. Nevertheless, shows complex composition, and active fraction is not known yet. In this context, protective total lyophilized extracts anthocyanin, neutral, or acidic fractions, was explored PC12 cells culture after hydrogen peroxide insult....
The origin and/or the evolution of brain diseases high morbidity and mortality such as cerebrovascular diseases, Alzheimers Dementia or Parkinsons disease have been linked to oxidative stress. Epidemiological clinical descriptive studies shown that diets with predominant vegetarian composition popular beverages like green tea red wine beneficial effects on general pathological markers flavonoids, ubiquitous polyphenols in plants vegetables, identified mainly by responsible for these actions....
Abstract Epidemiological studies have shown that flavonoid‐rich plants induce beneficial health effects are likely beyond their potent antioxidant capacity. Thus, the mechanisms by which Achyrocline satureioides (AS), a popular South American medicinal plant, protects cells and neurons in culture, still unclear. In this sense, recently described trophic capacity for flavonoids, similar to evoked growth factors, could be one of involved AS cellular protection. Since activity causes...
Epidemiological studies have shown positive preventive action of flavonoids on cardiovascular and neurodegenerative events. Among the six groups in which are classified, flavones flavonols, based backbone 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one) most commonly encountered within families genera higher plants. Numerous support a neuroprotective activity such as luteolin flavonols kaempherol quercetin experimental focal ischemia models neurodegeneration. Antioxidation, modulation...
Natural products play a crucial role in drug discovery, primarily due to their structural complexity. The prenylated flavanone, glabranin ((S)-5,7-dihydroxy-8-(3-methylbut-2-en-1-yl)-2-phenylchroman-4-one), isolated plant Dalea elegans, has demonstrated neuroprotective effects, attributed its inhibition of GSK-3β as per our previous silico studies. Given the enzyme's diverse functions and potential target for neurodegenerative diseases, group synthesized evaluated an 11C-labeled...
Abstract Background ApoE has been linked to individual differences in risk and resilience neurodegeneration normal aging. The ApoE4 genotype associated with an increased of developing late‐onset Alzheimer’s disease (age 65 older). Within the cognitively healthy population, important have reported distribution alleles their association cognitive performance, especially underrepresented groups. We describe subjects at dementia Uruguay, its assessment factors for dementia. Method we studied 73...