A5048431952- Glycosylation and Glycoproteins Research
- Ion channel regulation and function
- Ion Channels and Receptors
- Galectins and Cancer Biology
- ATP Synthase and ATPases Research
- Pancreatic and Hepatic Oncology Research
- Apelin-related biomedical research
- Amino Acid Enzymes and Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Helicobacter pylori-related gastroenterology studies
- Glycogen Storage Diseases and Myoclonus
- Pancreatic function and diabetes
- Cellular transport and secretion
- Pancreatitis Pathology and Treatment
- Ion Transport and Channel Regulation
- Caveolin-1 and cellular processes
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
La Ligue Contre le Cancer
2020-2025
Université de Lille
2020-2025
Inserm
2020-2025
Onco Lille
2020
Abstract There is growing evidence that ion channels are critically involved in cancer cell invasiveness and metastasis. However, the molecular mechanisms of signaling promoting behavior poorly understood complexity underlying remodeling during metastasis remains to be explored. Here, using a variety vitro vivo techniques, we show metastatic prostate cells acquire specific Na + /Ca 2+ signature required for persistent invasion. We identify leak channel, NALCN, which overexpressed cancer, as...
Pancreatic Ductal Adenocarcinoma (PDAC) is characterized by an acidic microenvironment, which contributes to therapeutic failure. So far there a lack of knowledge with respect the role microenvironment in invasive process. This work aimed study phenotypic and genetic response PDAC cells stress along different stages selection. To this end, we subjected short- long-term pressure recovery pHe 7.4. treatment at mimicking edges consequent cancer cell escape from tumor. The impact acidosis was...
Activated pancreatic stellate cells (aPSCs), the crucial mediator of desmoplasia, are characterized, among others, by high proliferative potential and abundant transforming growth factor β1 (TGFβ1) secretion. Over past years, involvement Ca2+ channels in PSC pathophysiology has attracted great interest cancer research. We, thus, aimed to investigate role Orai1 channel these two activation processes. Using siRNA approach, we invalided expression assessed functionality imaging, effect on aPSC...
<title>Abstract</title> Glycans are known to be fundamental for many cellular and physiological functions. Congenital disorders of glycosylation (CDGs) currently encompassing over 160 subtypes characterized by glycan synthesis and/or processing defects. Despite the increasing number CDG patients, therapeutic options remain very limited as our knowledge is often insufficient on involved molecular regulatory mechanisms synthesis. This worsened emergence significant subgroup resulting from...
Abstract Cytosolic Ca2+ oscillations provide signaling input to several effector systems of the cell. These include neuronal development, migration and networking. Although similar events are hijacked by highly aggressive cancer cells, complexity ‘neuron-like’ remodeling in metastasis remains be explored. Here, using a variety vitro vivo techniques we show that strongly metastatic prostate cells acquire specific Na+/Ca2+ signature required for persistent invasion. We identify ‘neuronal’ Na+...