A5077135710- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Growth Hormone and Insulin-like Growth Factors
- Biomarkers in Disease Mechanisms
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Oral Health Pathology and Treatment
- Enterobacteriaceae and Cronobacter Research
- Mesenchymal stem cell research
- Antibiotic Resistance in Bacteria
- Skin Diseases and Diabetes
- COVID-19 Clinical Research Studies
- Retinoids in leukemia and cellular processes
- S100 Proteins and Annexins
- RNA modifications and cancer
- Lipoproteins and Cardiovascular Health
- Atherosclerosis and Cardiovascular Diseases
- Research in Cotton Cultivation
- Transgenic Plants and Applications
- Regulation of Appetite and Obesity
- Bone health and osteoporosis research
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
Hebei General Hospital
2016-2025
Shantou University
2021-2022
Yue Bei People's Hospital
2021-2022
Shantou University Medical College
2022
Hospital of Hebei Province
2019
Wenzhou Medical University
2012-2013
Nanjing Agricultural University
2010
Objective In this study, we aimed to explore the relationship between postprandial triglyceride (TG) and thyroid stimulating hormone (TSH) levels compare TSH in participants with normal lipid tolerance reduced tolerance. Methods A total of 81 eligible were enrolled given a high-fat meal 1500 kcal, blood samples collected at 2, 4, 6, 8 hours. Fasting glucose, cholesterol, high-density lipoprotein low-density fasting TG, triiodothyronine (T3), tetraiodothyronine (T4), tested. Based on serum TG...
Background: Circular RNAs (circRNAs), which generally act as microRNA (miRNA) sponges to competitively regulate the downstream target genes of miRNA, play an essential role in cancer biology. However, few studies have been reported on circRNA based competitive endogenous RNA (ceRNA) network hepatocellular carcinoma (HCC). Herein, we aimed screen and establish circRNA/miRNA/mRNA networks related prognosis progression HCC further explore underlying mechanisms tumorigenesis. Methods: GEO...
The value of novel biomarkers for DKD has received increasing attention, and there is an urgent need with sensitivity, specificity ability to detect kidney damage.miR-377 regulates many basic biological processes, plays a key role in tumor cell proliferation, migration inflammation, can also increase the expression matrix proteins fibronectin, leading renal tubulointerstitial inflammation fibrosis. Lipoprotein-associated phospholipase A2, as inflammatory marker, involved pathological process...
IL-17 and other cytokines have a number of immunomodulatory effects on thyroid cells. The present study investigated the changes correlations amongst IL-17, NF-κB, IL-6, IL-10, interferon-γ (IFN-γ), TNF-α, IL-2 IL-4 in patients with different autoimmune diseases order to further clarify pathogenesis disease. A total 82 (41 Graves' disease 41 Hashimoto's thyroiditis) 53 healthy controls were enrolled. All relevant hormones detected by electrochemiluminescence analyzer. serum levels using flow...
Carbapenem resistance in Enterobacteriaceae is increasing and has become a matter of great concern. The aim this study was to characterize carbapenem-non-susceptible from teaching hospital. A total 49 clinical isolates recovered 2007–2010 the First Affiliated Hospital Wenzhou Medical College were analyzed by antimicrobial susceptibility testing. carbapenemase phenotype, outer membrane protein profiles, clonal relatedness investigated using modified Hodge test, sodium dodecyl...
A bacterial artificial chromosome (BAC) library for the A‐genome of cotton has been constructed from leaves G. arboreum L cv. Jianglinzhongmian. It is used as elite germplasm resources in present breeding program and to build a genetic reference map cotton. The BAC consists 123,648 clones stored 322 384‐well plates. Statistical analysis set 103 randomly selected indicated that each clone an average insert length 100.2 kb per plasmid, with range 30 190 kb. Theoretically, this represents 7.2...
To study the changes and effects of angiotensin-converting enzyme 2 (ACE2)/angiotensin 1-7 (Ang1-7) ACE/AngII in people with different glucose metabolisms to explore possible mechanisms underlying severity COVID-19 infection diabetic patients.A total 88 patients type diabetes, 72 prediabetes (impaired fasting glucose, 30 patients; impaired regulation, 42 patients), 50 controls were selected. Changes correlations ACE2, Ang1-7 other indicators detected among three groups. Patients divided into...
Background: This study aimed to screen potential drugs targeting a new prognostic gene signature associated with proliferation in hepatocellular carcinoma (HCC). Methods: CRISPR Library and TCGA datasets were used explore differentially expressed genes (DEGs) related the of HCC cells. Differential expression analysis, univariate COX regression random forest algorithm multiple combinatorial screening construct signature. Then predictive power was validated ICGC datasets. Furthermore, this...
Background Relationship has been identified in sporadic reports between polymorphisms and hypercholesterolemia. However, the relationship inflammatory cytokines polymorphism of low‐density lipoprotein receptor ( LDL ‐R) gene hypercholesterolemia is unclear. This study aimed to explore significance ‐R serum Interleukin‐2 IL ‐2), ‐10 patients with Methods PCR ‐ RFLP direct DNA sequencing assay were employed determine 900 400 healthy cases. ELISA was applied concentration ‐2 ‐10. Blood lipid...
Objective:The purpose of the study was to investigate expression levels and correlation inflammatory factors such as miR-377-3p TGF-β in patients with diabetic kidney disease (DKD), regulatory mechanism transfection on response HK-2 cell induced by high glucose.Methods: According UACR, were divided into normal albuminuria group (Con, n = 29), microalbuminuria (Micro, 31) macroalbuminuria (Macro, 30), analyzed influencing between DKD factor.HK-2 cells randomly four groups: control (NC),...
Abstract Objective: To investigate the expression changes and mechanism of oxidative stress IL-17 induced inflammatory factors in thyroid cancer with Hashimoto's thyroiditis. Method: 40 patients accompanied by thyroiditis were selected as PTC+HT group, 45 simple PTC 42 HT healthy individuals control group (NC). Evaluate indicators NO, eNOS, superoxide dismutase (SOD), IL-17A, IL-1β IL-6, hormones their antibodies TPOAb TGAb, well related biochemical indicators. Result: The such IL-17A...
Objective To study the vancomycin-resistant genes and virulence factors in Enterococci (VRE),and to analyze drug-resistance character epidemic characteristics of VRE strains provide basis for clincal selection drugs infection control.Methods were screened by agar dilution sieving plate (ADSP) containing 6 μg/ml vancomycin,drug resistance other common antibiotics detected VITEK-60 automatic microbial analyzer.The gene types factor determined PCR.And genetic relationships among multilocus...
Objective To explore the changes and clinical significance of serum prolactin estrogen levels in women with autoimmune thyroid diseases. Methods From January 2018 to December 2018, 76 newly diagnosed female patients diseasein outpatient inpatient clinics People's Hospital Hebei Province were selected as study group, including 40 cases Graves' disease 36 hashimoto's thyroiditis.And 60 healthy age matched control group.Serum estrogen, prolactin, hormone their antibodies, IL-2, IL-6,...
Abstract Background Acute Ischemic Stroke is a leading cause of death worldwide. Many clinical studies have focused on the correlation between thyroid axis hormones and disease outcomes, but results remain controversial. One possible reason for conflicting that association among prognostic factors varies in different age groups. our study effect aging degree thyroid-related ischemic stroke outcomes. Methods The retrospective was performed 1025 patient records. Included patients were three...
Abstract Objective: To analyze the levels and correlation of vitamin D, ACE2, ACE inflammatory factors in patients with type 2 diabetes,To explore effect D deficiency on ACE2 mechanism action occurrence development diabetes. Methods: Non-diabetic control 87 cases diabetes 96 cases,According to level serum 25-hydroxyvitamin 47 non-diabetic normal group 40 were divided into two groups.52 44 deficient tested for ACE, IL-6, TNF-a other indexes.The influencing each index analyzed. Results: The...