A5015256560- Organ Transplantation Techniques and Outcomes
- Metabolism, Diabetes, and Cancer
- Ovarian function and disorders
- Reproductive Biology and Fertility
- PI3K/AKT/mTOR signaling in cancer
- Circadian rhythm and melatonin
- Liver Disease Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Reproductive System and Pregnancy
- Anesthesia and Neurotoxicity Research
- Pregnancy and preeclampsia studies
- Psoriasis: Treatment and Pathogenesis
- Liver Disease and Transplantation
- Vitamin D Research Studies
- Hepatitis B Virus Studies
- Estrogen and related hormone effects
- Neonatal Health and Biochemistry
- Fatty Acid Research and Health
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Eicosanoids and Hypertension Pharmacology
- Birth, Development, and Health
Cairo University
2020-2024
Future University in Egypt
2022-2024
Abstract Background In conjunction with other antiviral medicines, sofosbuvir (SOF) is an essential therapy for chronic hepatitis C. There some debate over its influence on hepatic fibrosis. The use of nanotechnology in treatment has gained popularity, the goal delivering therapeutic substances to liver increase efficacy and decrease adverse effects. aim this study was demonstrate protective effect incorporating nanoparticle galactosylated taurocholate bilosomal formula SOF...
Background Preeclampsia is a systemic, multi-organ endotheliopathy, associated with oxidative injury to the blood–brain barrier (BBB). initiates cascade of events that include neuroinflammation. Recently, it was documented Wnt/β-catenin signaling pathway exerts neuroprotective effects and maintain BBB integrity. We investigate protective effect omega-3 against neurovascular complication preeclampsia its relation pathway. Methodology After confirmation day 0 pregnancy (G0), 24 adult pregnant...
ABSTRACTEnvironmental factors, such as sleep restriction, contribute to polycystic ovary syndrome (PCOS) by causing hyperinsulinemia, hyperandrogenism, insulin resistance, and oligo- or anovulation. This study aimed evaluate the effects of circadian rhythm disruption on reproductive metabolic functions investigate potential therapeutic benefits MitoQ10 hot tub therapy (HTT). Sixty female rats were divided into six groups: control, MitoQ10, HTT, three groups with PCOS induced continuous light...
Synchronized uterine receptivity with the time of implantation is crucial for pregnancy continuity. Vitamin D (VD) deficiency has been linked to failure implantation. Therefore, we tested link between Homeobox transcription factor-10/immunophilin FK506-binding protein 52 (HOXA-10/FKBP52) axis and in VD-deficient rats. The effect VD supplementation at different doses was also investigated. Forty-eight pregnant rats were divided into six groups (eight/group); normal control fed standard chow...
We used nicorandil, a K-ATP channel opener, to study the role of these channels in amelioration renal ischemia/reperfusion (I/R)-induced pancreatic injury, and possible involvement PI3K/Akt/mTOR signaling pathway. Forty-two male Wistar rats were included this study, six sacrificed for extraction bone marrow mesenchymal stem cells (BM-MSCs) conducting in-vitro work, others vivo equally divided into groups. Group 1 (sham control), but groups 2-6 subjected bilateral I/R: 2 (I/R); 3 (I/R-NC),...
Context: Insulin resistance and a disturbed lipid profile are common associations with type 2 diabetes mellitus (T2DM) different skin diseases, particularly psoriasis (PsO).
Diabetic nephropathy can be identified as diabetes mellitus's furthermost significant complications.Tne End-Stage Renal Disease is also a result of diabetic nephropathy.The first-line therapy for patients with accompanied by proteinuria renin-angiotensinaldosterone system inhibition.The possible renoprotective effect evaluation valsartan/ sacubitril (ARNI) on model induced in rats compared to valsartan, Metformin alone, or their combination goal this work was what aimed.Mature male are...
Hormonal disturbances, multiple ovarian cysts, and oligo-anovulation are the key features of polycystic syndrome (PCOS).Consistently, without a directly hormone-regulated animal model, we developed three phenotypes PCOS in rats to simulate reproductive-metabolic disturbances human PCOS.Twenty-four female Sprague-Dawley underwent vaginal smears for two sequential cycles exclude any PCOS-like rats.Rats were divided into following groups: healthy control, induced by high-fat, high-sugar (HFHS)...