A5054461236- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- Viral gastroenteritis research and epidemiology
- Emergency and Acute Care Studies
- Bacterial Infections and Vaccines
- Neonatal Respiratory Health Research
- Child and Adolescent Health
- Congenital Anomalies and Fetal Surgery
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Asthma and respiratory diseases
- Syphilis Diagnosis and Treatment
- Adolescent and Pediatric Healthcare
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dermatological diseases and infestations
- Epilepsy research and treatment
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Animal Virus Infections Studies
- Agriculture and Farm Safety
- Delphi Technique in Research
- Indigenous Health, Education, and Rights
The University of Sydney
2022-2024
The Kids Research Institute Australia
2016-2024
The University of Western Australia
2016-2024
Government of Western Australia Department of Health
2021-2023
Government of Western Australia
2023
Charles Darwin University
2022
Menzies School of Health Research
2022
Perth Children's Hospital
2021
Princess Margaret Hospital for Children
2021
Pneumococcal conjugate vaccine (PCV) was included in Australia's National Immunisation Program for all children from 2005. We assessed the impact of PCV on all-cause and pathogen-specific pneumonia hospitalizations Western Australian (WA) aged ≤16 years. All with pneumonia-related International Statistical Classification Diseases Related Health Problems, Tenth Revision, Modification diagnosis codes occurring WA-born (1996–2012) were linked to pathology records. Age-specific incidence rate...
Despite recent improvements in treatment modalities for cystic fibrosis (CF), there is currently limited evidence and a lack of consensus regarding optimal strategies the different aspects CF, including pulmonary exacerbations (PEx). We aimed to establish prospective cohort people with CF (pwCF) evaluate alternative approaches managing era modulator therapies. prospectively enrolled children adults receiving care at specialist centres across Australia. Participant data were systematically...
Objective To actively solicit adverse events experienced in the days following immunisation with quadrivalent inactivated influenza vaccine using Australia’s near real-time, participant-based safety surveillance system, AusVaxSafety. Design and setting Observational cohort study conducted 194 sentinel sites (primary care, hospital community-based clinics) across Australia. Participants Individuals aged ≥6 months who received a routine seasonal at participating site (n=102 911) responded to...
Respiratory syncytial virus (RSV) causes respiratory illness in young children and is most commonly associated with bronchiolitis. RSV typically occurs as annual or biennial winter epidemics temperate regions, less pronounced seasonality the tropics. We sought to characterise compare of bronchiolitis tropical Western Australia. examined over 13 years laboratory identifications hospitalisations children, using an extensive linked dataset from applied mathematical time series analyses identify...
Background The proportion of births via cesarean section (CS) varies worldwide and in many countries exceeds WHO-recommended rates. Long-term health outcomes for children born by CS are poorly understood, but limited data suggest that is associated with increased infection-related hospitalisation. We investigated the relationship between mode birth childhood hospitalisation high-income varying Methods findings conducted a multicountry population-based cohort study all recorded singleton live...
Abstract Background Untreated hepatitis C virus (HCV) infection can result in cirrhosis and hepatocellular cancer. Direct-acting antiviral (DAA) therapies are highly effective have few side effects compared to older interferon-based therapy. Despite the Australian government providing subsidised unrestricted access DAA therapy for chronic HCV infection, uptake has not been sufficient meet global target of eliminating as a public health threat by 2030. This study will offer people with...
Background Reliance on hospital discharge diagnosis codes alone will likely underestimate the burden of respiratory viruses. Objectives To describe epidemiology viruses more accurately, we used record linkage to examine data relating all children hospitalized in Western Australia between 2000 and 2012. Patients/Methods We extracted hospital, infectious disease notification laboratory a cohort born 1996 Laboratory records specimens collected within 48 hours admission were linked...
Introduction Studies examining acute respiratory infections (ARIs) in emergency department (EDs), particularly rural and remote areas, are rare. This study aimed to examine the burden of ARIs among Aboriginal non-Aboriginal children presenting Western Australian (WA) EDs from 2002 2012. Method Using a retrospective population-based cohort linking ED records birth perinatal records, we examined presentation rates for metropolitan, 469 589 births. We used diagnosis information categorise...
Several countries have developed national immunisation registers, but only the Nordic linked their registers to other health data in order comprehensively evaluate `real world' effectiveness of vaccines. can link datasets deterministically using person identifier, most countries, including Australia, don't such an identifier enable this type linkage.To describe process for assembling a study cohort that will conduct population-based studies related and policy.National death databases along...
The objective of this study was to describe the occurrence skin infection associated hospitalizations in children born Western Australia (WA). We conducted a retrospective cohort all WA between 1996 and 2012 (n = 469,589). Of these, 31,348 (6.7%) were Aboriginal 240,237 (51.2%) boys. report annual age-specific hospital admission rates by geographical location diagnostic category. applied log-linear regression modelling analyse changes temporal trends hospitalizations. Hospitalization for...
Significant progress has been made towards an effective respiratory syncytial virus (RSV) vaccine. Age-stratified estimates of RSV burden are urgently needed for vaccine implementation. Current limited to small cohorts or clinical coding data only. We present laboratory-confirmed across multiple severity levels.We linked laboratory, perinatal, and hospital 469 589 children born in Western Australia 1996-2012. Respiratory tests detections were classified into community, emergency department...
<h3>Importance</h3> Every year, influenza vaccines are administered to millions of people worldwide reduce morbidity and mortality from influenza. As new vaccine formulations increasingly used, monitoring comparing safety, in addition effectiveness, target populations essential. <h3>Objective</h3> To assess the postmarketing safety profile 2018 Southern Hemisphere vaccines, particularly 2 enhanced trivalent inactivated vaccines: an adjuvanted (aIIV3) high-dose (HD-IIV3), among Australian...
Pneumonia remains a leading cause of hospitalization and death among young children worldwide, the diagnostic challenge differentiating bacterial from non-bacterial pneumonia is main driver antibiotic use for treating in children. Causal Bayesian networks (BNs) serve as powerful tools this problem they provide clear maps probabilistic relationships between variables produce results an explainable way by incorporating both domain expert knowledge numerical data.We used data combination...
Background: Rotavirus vaccination was introduced into the Australian National Immunisation Program in mid-2007. We aimed to assess impact of rotavirus program on burden hospitalizations associated with all-cause acute gastroenteritis (including and non-rotavirus gastroenteritis) Aboriginal non-Aboriginal population Western Australia.