A5006940718- Acute Kidney Injury Research
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Cardiac Arrest and Resuscitation
- Dialysis and Renal Disease Management
- Erythropoietin and Anemia Treatment
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Thermal Regulation in Medicine
- Parasites and Host Interactions
- Non-Invasive Vital Sign Monitoring
- Drug-Induced Hepatotoxicity and Protection
- Gut microbiota and health
- Leptospirosis research and findings
- Cardiovascular and exercise physiology
- SARS-CoV-2 and COVID-19 Research
- Poisoning and overdose treatments
- Heart Rate Variability and Autonomic Control
- Parasitic Diseases Research and Treatment
- Nosocomial Infections in ICU
- Inhalation and Respiratory Drug Delivery
- Traumatic Brain Injury and Neurovascular Disturbances
- Mosquito-borne diseases and control
Siriraj Hospital
2023
Mahidol University
2023
King Chulalongkorn Memorial Hospital
2020-2022
Chulalongkorn University
2020-2021
Thai Red Cross Society
2021
When severe, COVID-19 shares many clinical features with bacterial sepsis. Yet, secondary infection is uncommon. However, as epithelium injured and barrier function lost, products entering the circulation might contribute to pathophysiology of COVID-19. We studied 19 adults, severely ill patients infection, who were admitted King Chulalongkorn Memorial Hospital, Bangkok, Thailand, between 13th March 17th April 2020. Blood samples on days 1, 3, 7 enrollment analyzed for endotoxin activity...
Currently, there is a lack of evidence to guide optimal care for acute kidney injury (AKI) survivors. Therefore, post-discharge by multidisciplinary team (MDCT) may improve these outcomes. This study aimed demonstrate the outcomes implementing comprehensive MDCT in severe AKI survivors.This was randomized controlled trial conducted between August 2018 January 2021. Patients who survived stage 2-3 were enrolled and be followed up with either or standard 12 months. The post-AKI involved an...
Abstract Purpose When severe, COVID-19 shares many clinical features with bacterial sepsis. Yet, secondary infection is uncommon. However, as epithelium are injured and barrier function lost, products entering the circulation might contribute to pathophysiology of COVID-19. Methods We studied 19 adults, severely ill patients infection, who were admitted King Chulalongkorn Memorial Hospital, Bangkok, Thailand, between 13 th March 17 April 2020. Blood samples on day 1, 3, 7 enrollment analyzed...
Leptospirosis can cause a high mortality rate, especially in severe cases. This multicenter cross-sectional study aimed to examine both host and pathogen factors that might contribute the disease severity. A total of 217 leptospirosis patients were recruited divided into two groups non-severe severe. Severe was defined by modified sequential organ failure assessment (mSOFA) score more than or needed for mechanical ventilation support had pulmonary hemorrhage death. We found leptospiremia,...
Citrate has been proposed as anticoagulation of choice in continuous renal replacement therapy (CRRT). However, little is known about the pharmacokinetics (PK) and metabolism citrate liver failure patients who require CRRT with regional (RCA). This prospective clinical PK study was conducted at King Chulalongkorn Memorial Hospital between July 2019 to April 2021, evaluating seven acute (ALF) acute-on-chronic (ACLF) received support utilizing RCA an anticoagulant a dose 3 mmol/L. For...
<b><i>Introduction:</i></b> Uncontrolled systemic inflammation may occur in severe coronavirus disease 19 (COVID-19). We have previously shown that endotoxemia, presumably from the gut, complicate COVID-19. However, role of endotoxin adsorbent (EA) therapy to mitigate organ dysfunction COVID-19 has not been explored. <b><i>Methods:</i></b> conducted a retrospective observational study patients who received EA at King Chulalongkorn Memorial...
ABSTRACT Background Current guidelines recommend monitoring of post-filter ionized calcium (pfCa) when using regional citrate anticoagulation during continuous renal replacement therapy (RCA-CRRT) to determine efficiency for the prevention filter clotting. However, reliability pfCa raises question whether routine is required. Reducing frequency could potentially reduce costs and workload. Our objective was test efficacy safety no among critically ill patients receiving RCA-CRRT. Methods This...
Objective: Heart rate variability (HRV) and baroreflex sensitivity (BRS) are influenced by various internal external factors, making it necessary to establish universal reference values. We aimed identify independent factors affecting short-term HRV parameters BRS, as well determine appropriate ranges, which lacking in Asian populations. Materials Methods: A total of 117 healthy Thai participants (aged 20-72 years; final n=117) were recruited based on strict criteria, including normal...
Abstract We aimed to evaluate the impact of citrate on hemodynamic responses and secondary outcomes, including filter life span, metabolic complications, levels inflammatory cytokines, in critically ill patients who required CRRT compared with those underwent heparin-free method. This prospective, multicenter, open-label randomized trial regional anticoagulation (RCA) a protocol severe acute kidney injury (AKI) received continuous venovenous hemodiafiltration (CVVHDF) postdilution mode....
Acute kidney injury (AKI) survivors are at an increased risk of chronic disease, end-stage and mortality. Little is known about the effect erythropoietin (EPO), a kidney-producing hormone, in post-AKI setting. We aimed to investigate role EPO as predictor long-term outcomes post-severe AKI survivors.We performed retrospective analysis cohort conducted between August 2018 December 2021. Adults who survived severe stages 2-3 were enrolled. Serum was obtained 1 month after hospital discharge....
Abstract Background: Currently, there is a lack of evidence to guide the optimal care for post-acute kidney injury (AKI) survivors. Therefore, post-discharge by multidisciplinary team (MDCT) may improve these outcomes. This study aimed demonstrate outcomes implementing comprehensive MDCT in post-severe AKI Methods: was randomized controlled trial conducted between August 2018 January 2021. Patients who survived severe stage 2-3 were enrolled and be followed up with either or standard 12...